Role of IL-6/IL-10 ratio in the diagnosis and in the assessment of the severity of obsessive-compulsive disorder

Esawy, Marwa M.; Shabana, Marwa A.; Ali, Eman

doi:10.1007/s00580-018-2803-5

Cited by 4 publications

(7 citation statements)

References 38 publications

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“…These results suggested that OCD patients displayed heightened inflammatory responses compared to HCs and that these elevated pro-inflammatory cytokines might be associated with the pathophysiology of OCD. Our results are consistent with those reported by several studies that also observed a significant elevation of IL-1β and or IL-6 serum levels in OCD patients compared to HCs [ 1 , 16 , 31 , 49 ]. However, our results are incompatible with some other studies that reported decreased IL-6 serum levels in OCD, or the difference of IL-1β or IL-6 levels between OCD patients and HCs did not approach the statistically significant levels [ 29 , 34 ].…”

Section: Discussionsupporting

confidence: 93%

“…We also observed positive correlations for the elevated levels of both cytokines with the severity of OCD patients. Our study findings resonate with those reported by studies that also observed a significant positive correlation between cytokine levels and OCD symptoms severity [ 14 , 31 ]. However, our results are inconsistent with a few studies that failed to find any significant association between blood cytokine levels (IL-1β, IL-6) and Y-BOCS scores [ 1 , 29 ].…”

Section: Discussionsupporting

confidence: 92%

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Exploring the role of interleukin-1β and interleukin-6 in the pathophysiology of obsessive-compulsive disorder

Sarmin,

Roknuzzaman,

Sarker

et al. 2024

PLoS ONE

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Background Obsessive-compulsive disorder (OCD) is a highly prevalent neuropsychiatric disorder. Recently, there has been a growing interest in investigating the association between pro-inflammatory cytokines and the pathogenesis of OCD. However, studies targeting interleukin-1β (IL-1β) and interleukin-6 (IL-6) in OCD are limited. Therefore, the present study aimed to explore the potential role of pro-inflammatory cytokines IL-1β and IL-6 in the pathophysiology and development of OCD. Methods This study recruited 58 OCD patients and 30 age-sex-matched healthy controls (HCs). A qualified psychiatrist diagnosed OCD patients and assessed HCs based on the Diagnostic and Statistical Manual for Mental Health Disorders, 5th edition (DSM-5) criteria. We measured the severity of OCD using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Serum IL-1β and IL-6 levels were measured using ELISA kits following the appropriate methods. Results The results showed that serum IL-1β levels were significantly elevated in OCD patients compared to HCs (23.68±1.65 pg/ml vs. 15.75±1.02 pg/ml; p = 0.002). Similarly, OCD patients exhibited significantly higher serum IL-6 levels than HCs (44.97±0.73 pg/ml vs. 37.04±0.35 pg/ml; p<0.001). We observed both cytokines were positively correlated with the Y-BOCS scores in OCD patients (IL-1β: r = 0.380, p = 0.015; IL-6: r = 0.324, p = 0.026) which indicates their role in disease pathophysiology. Conclusion These results suggest that serum IL-1β and IL-6 levels may be associated with the pathophysiology of OCD. Also, these cytokines levels in blood samples can serve as early risk assessment tools for the development of OCD. We recommend further studies in a large and homogeneous population to support these findings.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Exploring the role of interleukin-1β and interleukin-6 in the pathophysiology of obsessive-compulsive disorder

Sarmin,

Roknuzzaman,

Sarker

et al. 2024

PLoS ONE

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“…The applicability of the systemic IL-6/IL-10 ratio has also been verified to identify the severity of other diseases, such as obsessive-compulsive disorder and pneumonia. 13,15 And thus, this examination may aid ophthalmologists in deciding therapeutic choices for severe cases, although further studies with a larger sample size are required for future validation.…”

Section: Discussionmentioning

confidence: 99%

“…1,7,11 Additionally, the balance between systemic pro-and anti-inflammatory response has been well documented to influence various diseases, including glaucoma. [12][13][14][15] The role of IL-6 is widely investigated in several ocular diseases. 16,17 While IL-6 is recognized as a multifunctional cytokine, IL-6 generally acts as a pro-inflammatory cytokine.…”

Section: Serum Il-6/il-10 Ratio As a Biomarker For The Diagnosis And ...mentioning

confidence: 99%

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Serum IL-6/IL-10 ratio as a biomarker for the diagnosis and severity assessment of primary-open angle glaucoma

Ulhaq

Soraya

Hasan

et al. 2021

European Journal of Ophthalmology

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Objective: To assess the performance of serum cytokine IL-6 and IL-6/IL-10 ratio as biomarkers for the diagnosis of primary open-angle glaucoma (POAG) and for determining its progression. Methods: In this study, 20 POAG patients and 21 healthy individuals from the Indonesian population were enrolled. The serum concentration of IL-6 and IL-10 were quantified. Comparative analysis was performed in addition to assessment of the diagnostic performance of cytokines using receiver-operating-curve (ROC) analysis. Results: POAG patients had a higher IL-6 ( p < 0.0001) and IL-6/IL-10 ratio ( p < 0.0001) than controls. Among the POAG subjects, advanced-stage patients exhibited a higher IL-6/IL-10 ratio than those in the early-moderate stage ( p = 0.001; p = 0.006). The ROC curve analysis showed that both IL-6 level and IL-6/IL-10 ratio exhibited an excellent capability of diagnosing POAG (cut-off of 20.5 pg/mL (100% sensitivity and 94% specificity) and 4.4 (88% sensitivity and 94% specificity), respectively). Serum IL-6/IL-10 ratio displayed a better performance than IL-6 in discriminating POAG severity with cut-off of at least 6.6 (sensitivity of 86% and specificity of 90%) and 9.1 (sensitivity of 89% and specificity of 78%) classified according to C/D ratio and MD of VF, respectively. Conclusion: The balance between IL-6 and IL-10 serum levels is potentially useful in discriminating POAG severity.

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Differential effects of lipopolysaccharide on cognition, corticosterone and cytokines in socially-housed vs isolated male rats

Russell

Hrelja

Adams

et al. 2022

Behavioural Brain Research

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Role of IL-6/IL-10 ratio in the diagnosis and in the assessment of the severity of obsessive-compulsive disorder

Cited by 4 publications

References 38 publications

Exploring the role of interleukin-1β and interleukin-6 in the pathophysiology of obsessive-compulsive disorder

Exploring the role of interleukin-1β and interleukin-6 in the pathophysiology of obsessive-compulsive disorder

Serum IL-6/IL-10 ratio as a biomarker for the diagnosis and severity assessment of primary-open angle glaucoma

Differential effects of lipopolysaccharide on cognition, corticosterone and cytokines in socially-housed vs isolated male rats

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