Role of <i>Porphyromonas gingivalis</i> in oral and orodigestive squamous cell carcinoma

Lamont, Richard J.; Fitzsimonds, Zackary R.; Wang, Huizhi; Gao, Shegan

doi:10.1111/prd.12425

Cited by 50 publications

(34 citation statements)

References 143 publications

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“…In contrast to the long‐established potential of viruses as carcinogenic agents, interest in the role of bacteria in the etiology of cancer is relatively recent, having gained momentum after the association of Helicobacter pylori with gastric cancer in the 1990s. Lamont and colleagues 50 review emerging evidence for an association between periodontal pathogens, such as P gingivalis , and oral/orodigestive squamous cell carcinoma. Although the discussed studies are correlative and causality remains to be addressed, the authors describe potential carcinogenic mechanisms, established in in vitro models, whereby P gingivalis may contribute to carcinogenesis.…”

Section: Cancermentioning

confidence: 99%

Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications

Hajishengallis

2022

Periodontology 2000

130

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Periodontitis, a microbiome‐driven inflammatory disease of the tooth‐attachment apparatus, is epidemiologically linked with other disorders, including cardio‐metabolic, cognitive neurodegenerative and autoimmune diseases, respiratory infections, and certain cancers. These associations may, in part, be causal, as suggested by interventional studies showing that local treatment of periodontitis reduces systemic inflammation and surrogate markers of comorbid diseases. The potential cause‐and‐effect connection between periodontitis and comorbidities is corroborated by studies in preclinical models of disease, which additionally provided mechanistic insights into these associations. This overview discusses recent advances in our understanding of the periodontitis‐systemic disease connection, which may potentially lead to innovative therapeutic options to reduce the risk of periodontitis‐linked comorbidities.

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Section: Cancermentioning

confidence: 99%

Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications

Hajishengallis

2022

Periodontology 2000

130

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“…Their presence was suggested to be cancer protective [ 73 ]. However, in cancer, development metabolism and the functionally specialized role of the bacterial community are more relevant than composition [ 74 ].…”

Section: Bacterial Communities Associated With Osccmentioning

confidence: 99%

Microbiota and Oral Cancer as A Complex and Dynamic Microenvironment: A Narrative Review from Etiology to Prognosis

Pignatelli

Romei

Bondi

et al. 2022

IJMS

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A complex balanced equilibrium of the bacterial ecosystems exists in the oral cavity that can be altered by tobacco smoking, psychological stressors, bad dietary habit, and chronic periodontitis. Oral dysbiosis can promote the onset and progression of oral squamous cell carcinoma (OSCC) through the release of toxins and bacterial metabolites, stimulating local and systemic inflammation, and altering the host immune response. During the process of carcinogenesis, the composition of the bacterial community changes qualitatively and quantitatively. Bacterial profiles are characterized by targeted sequencing of the 16S rRNA gene in tissue and saliva samples in patients with OSCC. Capnocytophaga gingivalis, Prevotella melaninogenica, Streptococcus mitis, Fusobacterium periodonticum, Prevotella tannerae, and Prevotella intermedia are the significantly increased bacteria in salivary samples. These have a potential diagnostic application to predict oral cancer through noninvasive salivary screenings. Oral lactic acid bacteria, which are commonly used as probiotic therapy against various disorders, are valuable adjuvants to improve the response to OSCC therapy.

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“…A possibility by which P. gingivalis activates the development of esophageal cancers should involve the NF-κB signaling ( 23 ). Actually, the causative and promotion role of P. gingivalis in oral cancers and in OSCC appears confirmed in recent reports and meta-analyses ( 24 , 25 ). As P. gingivalis is the major causative microbial agent of periodontitis ( 26 ), therefore its association with oral cancers pertains to the direct association with previous gum and dental hygiene impairments leading to periodontitis ( 5 , 27 ), and this may be beyond the purpose of our report.…”

Section: The Oral Microbiome Composition In the Hygiene Perspective O...mentioning

confidence: 62%

Oral microbiota in oropharyngeal cancers: Friend or foe?

Nocini

Muzio²,

Gibellini³

et al. 2022

Front. Oncol.

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Oral microbiome is a complex population of micro-organisms, which by cross-talking with the local immune system, plays a major role in the immune homeostasis of the oral cavity, further contributing in the physiology of the gastro-intestinal microbiota. Understanding their involvement in the onset and pathogenesis of oropharyngeal cancers is paramount, despite very few reports deal with the fundamental role exerted by oral microbiota disorders, such as dysbiosis and impairment in the oral microbiome composition as causative factors in the development of oropharyngeal tumors. Current research, via metabolomic or meta-transcriptomic analyses, is wondering how this complex microbial population regulates the immune homeostasis in oral and pharyngeal mucosa and whether changes in bacterial composition may give insights on the role of oral microbiome in the development of oropharyngeal tumors, so to prevent their occurrence.

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Role of Porphyromonas gingivalis in oral and orodigestive squamous cell carcinoma

Abstract: Cancers of the head and neck region are predominantly squamous cell carcinomas, 12 and include carcinomas of the oropharynx (including the base of the tongue), generally referred to as oropharyngeal

Cited by 50 publications

References 143 publications

Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications

Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications

Microbiota and Oral Cancer as A Complex and Dynamic Microenvironment: A Narrative Review from Etiology to Prognosis

Oral microbiota in oropharyngeal cancers: Friend or foe?

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