Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications

Hajishengallis, George

doi:10.1111/prd.12430

Cited by 161 publications

(137 citation statements)

References 66 publications

(112 reference statements)

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“…The infection of H. pylori is highly correlated with oral diseases ( Perez-Perez et al., 2004 ; Anand et al., 2006 ), and the shift of oral microbial community induced by H. pylori is one of the potent reasons for the oral diseases ( Martin and Solnick, 2014 ). Periodontitis, a common microbiome-driven inflammatory disease ( Hajishengallis, 2022 ), was highly related to H. pylori infection. P. gingivalis , as an established pathogenic agent of periodontitis ( Miller and Scott, 2021 ), had a positive correlation with H. pylori .…”

Section: Helicobacter Pylori and Oral Microbiomementioning

confidence: 99%

The interactions between oral-gut axis microbiota and Helicobacter pylori

Chen

Wang

et al. 2022

Front. Cell. Infect. Microbiol.

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In the human body, each microbial habitat exhibits a different microbial population pattern, and these distinctive microflorae are highly related to the development of diseases. The microbial interactions from host different niches are becoming crucial regulators to shape the microbiota and their physiological or pathological functions. The oral cavity and gut are the most complex and interdependent microbial habitats. Helicobacter pylori is one of the most important pathogens from digestive tract, especially the stomach, due to its direct relationships with many gastric diseases including gastric cancer. H. pylori infections can destroy the normal gastric environment and make the stomach a livable channel to enhance the microbial interactions between oral cavity and gut, thus reshaping the oral and gut microbiomes. H. pylori can be also detected in the oral and gut, while the interaction between the oral-gut axis microbiota and H. pylori plays a major role in H. pylori’s colonization, infection, and pathogenicity. Both the infection and eradication of H. pylori and its interaction with oral-gut axis microbiota can alter the balance of the microecology of the oral-gut axis, which can affect the occurrence and progress of related diseases. The shift of oral-gut axis microbiota and their interactions with H. pylori maybe potential targets for H. pylori infectious diagnosis and treatment.

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Section: Helicobacter Pylori and Oral Microbiomementioning

confidence: 99%

The interactions between oral-gut axis microbiota and Helicobacter pylori

Chen

Wang

et al. 2022

Front. Cell. Infect. Microbiol.

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“…It is intriguing to note that the oral cavity function as the gateway for external microorganisms and those that inhabit the mouth and associated structures impact distant systems and organs such as the eye. As it is scientifically proven that many systemic diseases manifest in the oral cavity, it is also known that chronic inflammation originating from the oral cavity influence the pathogenesis of diseases at the systemic level [ 61 ]. Several latest studies have strongly suggested the existence of a gut-retinal axis, emphasizing the role of dysbiosis of gut microbiota in the inception and advancement of uveitis [ 62 ], AMD [ 63 ], and glaucoma [ 64 ].…”

Section: Oral Microbiomementioning

confidence: 99%

Do Oral Pathogens Inhabit the Eye and Play a Role in Ocular Diseases?

Arjunan

Swaminathan

2022

JCM

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Fascinatingly, the immune-privileged healthy eye has a small unique population of microbiota. The human microbiome project led to continuing interest in the ocular microbiome. Typically, ocular microflorae are commensals of low diversity that colonize the external and internal sites of the eye, without instigating any disorders. Ocular commensals modulate immunity and optimally regulate host defense against pathogenic invasion, both on the ocular surface and neuroretina. Yet, any alteration in this symbiotic relationship culminates in the perturbation of ocular homeostasis and shifts the equilibrium toward local or systemic inflammation and, in turn, impaired visual function. A compositional variation in the ocular microbiota is associated with surface disorders such as keratitis, blepharitis, and conjunctivitis. Nevertheless, innovative studies now implicate non-ocular microbial dysbiosis in glaucoma, age-related macular degeneration (AMD), uveitis, and diabetic retinopathy. Accordingly, prompt identification of the extra-ocular etiology and a methodical understanding of the mechanisms of invasion and host-microbial interaction is of paramount importance for preventative and therapeutic interventions for vision-threatening conditions. This review article aims to explore the current literature evidence to better comprehend the role of oral pathogens in the etiopathogenesis of ocular diseases, specifically AMD.

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“…Globally, periodontitis prevalence is estimated to affect 20 to 50 percent adults [ 2 ]. Periodontitis is associated with multiple systemic diseases and metabolic disorders including obesity, cardiovascular disease, and diabetes, among others [ 3 ]. Apart from shared risk factors, systemic inflammatory burden arising from chronic periodontal infection is considered central to the risk increment for systemic diseases attributed to periodontal disease [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Periodontitis is associated with multiple systemic diseases and metabolic disorders including obesity, cardiovascular disease, and diabetes, among others [ 3 ]. Apart from shared risk factors, systemic inflammatory burden arising from chronic periodontal infection is considered central to the risk increment for systemic diseases attributed to periodontal disease [ 3 – 5 ]. Hypertensive disorders of pregnancy are highly prevalent and pose risk for maternal and neonatal mortality and morbidity.…”

Section: Introductionmentioning

confidence: 99%

Circulating miRNAs as Epigenetic Mediators of Periodontitis and Preeclampsia Association

Zhang

et al. 2022

Disease Markers

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Objective. Periodontal disease has been associated with pregnancy complications including preeclampsia. This bioinformatic study is aimed at investigating the possible role of circulating microRNAs (miRNAs) as mediators of the association between maternal periodontal disease and preeclampsia. Methods. Peripheral blood miRNA profiles of periodontitis and controls were sought from Gene Expression Omnibus (GEO), and differential expression analysis was performed. Experimentally validated circulating miRNAs associated with preeclampsia were determined from the Human MicroRNA Disease Database (HMDD v3.0). Venn diagrams were drawn to identify shared circulating differential miRNAs (DEmiRNAs). Significantly enriched target genes, KEGG pathways, and Gene Ontology (GO) terms for the set of shared DEmiRNA were predicted using miRNA enrichment analysis and annotation tool (miEAA v 2.0). Additionally, the shared DEmiRNA-enriched target genes were analyzed for enriched WikiPathways, BioCarta metabolic pathways, and tissue proteins in the human proteome map. Results. Among 183 circulating DEmiRNA in periodontitis and 60 experimentally validated miRNA in preeclampsia, 9 shared DEmiRNA were identified. The top among 32 overrepresented target genes included MAFB, PSAP, and CDK5RAP2, top among 14 enriched KEGG pathways were renin-angiotensin system and graft-versus-host disease, and that among enriched 44 GO profiles included “positive regulation of epidermal growth factor-activated receptor activity” and “sequestering of calcium ion.” In the overrepresented target gene set, among 10 enriched WikiPathways, the top included “NAD metabolism, sirtuins, and aging” and “regulation of Wnt/B-catenin signaling by small molecule compounds” and PPAR-related mechanisms was top among 13 enriched BioCarta metabolic pathways. Conclusion. A circulating 9-DEmiRNA set was significantly linked to both periodontitis and preeclampsia. Enrichment analysis identified specific genes, pathways, and functional mechanisms, which may be epigenetically altered and thereby mediate the biological association of periodontitis and preeclampsia.

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Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications

Cited by 161 publications

References 66 publications

The interactions between oral-gut axis microbiota and Helicobacter pylori

The interactions between oral-gut axis microbiota and Helicobacter pylori

Do Oral Pathogens Inhabit the Eye and Play a Role in Ocular Diseases?

Circulating miRNAs as Epigenetic Mediators of Periodontitis and Preeclampsia Association

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