Role ofHelicobacter pyloriand interleukin 6 -174 gene polymorphism in dyslipidemia: a case–control study

Abstract

ObjectiveTo assess the role of Helicobacter pylori infection and interleukin 6 polymorphism -174 (rs1800795) in dyslipidemia.DesignCase–control study comparing serum lipids between H. pylori positive and negative patients and controlling for IL-6 -174 polymorphism, age, sex and smoking.Setting3 hospitals performing outpatient endoscopies in the city of Oulu, Finland.Participants199 adult patients with dyspepsia symptoms fulfilling Rome criteria originating from ethnically Finnish population. Patients with an immunosuppressive disorder or malignant disease, treated H. pylori infection, immunosuppressive or anticoagulant medication, previous gastric surgery or ongoing antibiotic treatment were excluded.Primary outcome measuresAssociation of H. pylori infection and serum lipid concentrations in the whole group or in genotype-based subgroups. The associations between peptic ulcer, gastric mucosal inflammation and serum lipid concentrations were assessed as secondary outcomes.ResultsThe median high-density lipoprotein (HDL) serum concentration was significantly lower in the H. pylori positive group (0.81 mmol/L) than in the negative group (0.95 mmol/L; p<0.001). In the genotype subgroup analyses, a similar association between H. pylori infection and HDL serum levels was seen within the IL-6 -174 CC genotype group (HDL 0.72 vs 1.06 mmol/L, respectively; p<0.001), but no significant associations were seen in the GC or GG genotype groups. Additionally, patients with peptic ulcer demonstrated lower HDL levels (0.75 mmol/L) than H. pylori positive patients without ulcer (0.86 mmol/L; p=0.010).ConclusionsH. pylori infection associated significantly with low serum levels of HDL in the IL-6 -174 CC genotype patients but not in the other genotypes. This suggests that the association between H. pylori infection and serum HDL could be transmitted through IL-6. We suggest that the role of IL-6 genotype should also be studied in relation to other associations between gastrointestinal microbiome and cardiovascular risk factors.

Current Helicobacter pylori infection is significantly associated with subclinical coronary atherosclerosis in healthy subjects: A cross-sectional study

“…As chronic H . pylori infection is thought to induce systemic inflammation through cytokines such as interleukin-6 [ 44 , 51 ], not only coronary but also peripheral vascular changes can occur [ 58 ]. However, the mean PWV was not different according to the CLO positivity in our study.…”

Of genes and microbes: solving the intricacies in host genomes

“…We performed a literature search centred around the host gene, microbiome and diseases and have listed the most prominent examples where hypothesis-driven studies were carried either in humans (using natural variations) or mice (knock-out models) with respect to changes in the microbiome. We listed the changes observed, as well as the study context (type of disease), which we can see the primary focus on IBD Gene name Traits associated with genetic variations Context of study References Human IL13 / CD14 Interaction with cesarean delivery and prenatal exposure to antibiotics to affect skin microbiome Atopic dermatitis Lee et al ( 2014 ) FUT2 Airway microbiome ( Pseudomonas aeruginosa ) Bronchiectasis Taylor et al ( 2017 ) IL6 Helicobacter pylori Dyslipidemia Pohjanen et al ( 2016 ) ATG16L1 Fusobacteriaceae , Bacteroidaceae , Lachnospiraceae , Enterobacteriaceae , E . coli IBD Sadaghian Sadabad et al ( 2015 ) CARD9 Gut microbiome composition IBD Lamas et al ( 2016 ) FUT2 Gut microbiome composition, diversity and structure IBD Rausch et al ( 2011a , b ) NLRP12 Gut microbiome diversity IBD Chen et al ( 2017a , b ) NOD2 Gut microbiome composition IBD de Bruyn et al ( …”

Promoter Polymorphism (-174, G/C) of Interleukin-6 and Arterial Thromboembolic Events: A Meta-Analysis

“…The rs1800795 polymorphism has been examined in many previous studies. An association between Helicobacter pylori infection and decreased high-density lipoprotein (HDL) levels could be transmitted through its genotype of the IL-6 gene [14]. In patients with type 2 diabetes, rs1800795 SNP of the IL-6 gene is significantly related to increased risk of cardiovascular disease [15].…”