Role of hydrogen sulfide in endothelial dysfunction: Pathophysiology and therapeutic approaches

Citi, Valentina; Martelli, Alma; Gorica, Era; Brogi, Simone; Testai, Lara; Calderone, Vincenzo

doi:10.1016/j.jare.2020.05.015

Cited by 78 publications

(80 citation statements)

References 162 publications

(190 reference statements)

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“…Altered levels of H 2 S have been reported in both experimental models and clinical studies on patients with severe hypertension, where lower plasma H 2 S levels are described along with reduced content of CBS and CSE (see [ 77 , 78 ] for recent reviews). A human cohort study demonstrated a reduced H 2 S plasma level in hypertensive patients, suggesting H 2 S as a potential therapeutic target and diagnostic marker [ 79 ].…”

Section: Cardiovascular Diseases Associated With Altered Levels Ofmentioning

confidence: 99%

“…The relation between diabetes-induced endothelial dysfunction and H 2 S impairment is now well established (for review see [ 77 , 97 ]). H 2 S levels have been observed to be reduced in rats with diabetes induced by streptozotocin (STZ) and in subjects with type 2 diabetes mellitus [ 98 , 99 , 100 , 101 , 102 ].…”

Section: Cardiovascular Diseases Associated With Altered Levels Ofmentioning

confidence: 99%

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Endothelium as a Source and Target of H2S to Improve Its Trophism and Function

2021

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The vascular endothelium consists of a single layer of squamous endothelial cells (ECs) lining the inner surface of blood vessels. Nowadays, it is no longer considered as a simple barrier between the blood and vessel wall, but a central hub to control blood flow homeostasis and fulfill tissue metabolic demands by furnishing oxygen and nutrients. The endothelium regulates the proper functioning of vessels and microcirculation, in terms of tone control, blood fluidity, and fine tuning of inflammatory and redox reactions within the vessel wall and in surrounding tissues. This multiplicity of effects is due to the ability of ECs to produce, process, and release key modulators. Among these, gasotransmitters such as nitric oxide (NO) and hydrogen sulfide (H2S) are very active molecules constitutively produced by endotheliocytes for the maintenance and control of vascular physiological functions, while their impairment is responsible for endothelial dysfunction and cardiovascular disorders such as hypertension, atherosclerosis, and impaired wound healing and vascularization due to diabetes, infections, and ischemia. Upregulation of H2S producing enzymes and administration of H2S donors can be considered as innovative therapeutic approaches to improve EC biology and function, to revert endothelial dysfunction or to prevent cardiovascular disease progression. This review will focus on the beneficial autocrine/paracrine properties of H2S on ECs and the state of the art on H2S potentiating drugs and tools.

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Section: Cardiovascular Diseases Associated With Altered Levels Ofmentioning

confidence: 99%

Section: Cardiovascular Diseases Associated With Altered Levels Ofmentioning

confidence: 99%

Endothelium as a Source and Target of H2S to Improve Its Trophism and Function

2021

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“…Nrf-2 is accountable for inducing the expression of multiple antioxidant genes and averting oxidative injury. This kind of mechanism of action has also been defined for synthetic thiocyanate, whose H 2 S donor profile has been extensively discussed [ 147 , 165 , 166 , 167 , 168 , 169 , 170 , 171 ]. Anethiole dithiolethione has often been an H 2 S donor or a compound for developing H 2 S-releasing hybrid drugs with the non-steroidal anti-inflammatory agents H 2 S-diclofenac and H 2 S-aspirin.…”

Section: H 2 S In Pulmonary Inflammationmentioning

confidence: 99%

The Role of Hydrogen Sulfide in Respiratory Diseases

et al. 2021

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Respiratory diseases are leading causes of death and disability around the globe, with a diverse range of health problems. Treatment of respiratory diseases and infections has been verified to be thought-provoking because of the increasing incidence and mortality rate. Hydrogen sulfide (H2S) is one of the recognized gaseous transmitters involved in an extensive range of cellular functions, and physiological and pathological processes in a variety of diseases, including respiratory diseases. Recently, the therapeutic potential of H2S for respiratory diseases has been widely investigated. H2S plays a vital therapeutic role in obstructive respiratory disease, pulmonary fibrosis, emphysema, pancreatic inflammatory/respiratory lung injury, pulmonary inflammation, bronchial asthma and bronchiectasis. Although the therapeutic role of H2S has been extensively studied in various respiratory diseases, a concrete literature review will have an extraordinary impact on future therapeutics. This review provides a comprehensive overview of the effective role of H2S in respiratory diseases. Besides, we also summarized H2S production in the lung and its metabolism processes in respiratory diseases.

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“…Reduced levels of H 2 S have been found in patients with acute or stable coronary artery disease [ 158 ], hypertension [ 159 ], and heart failure [ 160 ]. The impact of H 2 S on cardiovascular disease has been extensively updated and reviewed in recent studies [ 161 , 162 , 163 , 164 , 165 ].…”

Section: H 2 S On Cardiovascular Diseasementioning

confidence: 99%

The Impact of H2S on Obesity-Associated Metabolic Disturbances

Comas

Moreno-Navarrete

2021

Antioxidants

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Over the last several decades, hydrogen sulfide (H2S) has gained attention as a new signaling molecule, with extensive physiological and pathophysiological roles in human disorders affecting vascular biology, immune functions, cellular survival, metabolism, longevity, development, and stress resistance. Apart from its known functions in oxidative stress and inflammation, new evidence has emerged revealing that H2S carries out physiological functions by targeting proteins, enzymes, and transcription factors through a post-translational modification known as persulfidation. This review article provides a critical overview of the current state of the literature addressing the role of H2S in obesity-associated metabolic disturbances, with particular emphasis on its mechanisms of action in obesity, diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular diseases.

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Role of hydrogen sulfide in endothelial dysfunction: Pathophysiology and therapeutic approaches

Abstract: Graphical abstract

Cited by 78 publications

References 162 publications

Endothelium as a Source and Target of H2S to Improve Its Trophism and Function

Endothelium as a Source and Target of H2S to Improve Its Trophism and Function

The Role of Hydrogen Sulfide in Respiratory Diseases

The Impact of H2S on Obesity-Associated Metabolic Disturbances

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