Role of homocysteine in age-related vascular and non-vascular diseases

Parnetti, Lucilla; Bottiglieri, Teodoro; Löwenthal, David

doi:10.1007/bf03341827

Cited by 71 publications

(63 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the accumulation of Hcys, a consequence of vitamin-B deficiency, has been demonstrated to be toxic to neurons and blood vessels, inducing DNA strand breakage, oxidative stress, and apoptosis (Coppen & Bolander-Gouaille, 2005;Folstein, et al, 2007;M. Johansson, et al, 2009;Lamprecht & Lipkin, 2003;Parnetti, Bottiglieri, & Lowenthal, 1997). Studies have shown increased prevalence of folate or B12 deficiency and elevated Hcys among neuropsychiatry patients with dementia, cognitive impairment, or mood disorder (Coppen & Bolander-Gouaille, 2005;Folstein, et al, 2007;Ortega et al, 1996;Reif, Schneider, Kamolz, & Pfuhlmann, 2003;Reynolds, 2006;Smith, 2008;, although this observation is not a consensus, inclusive among the elderly population (Beydoun, et al, 2010;Bjelland, Tell, Vollset, Refsum, & Ueland, 2003;Forti et al, 2010;Ng, Feng, Niti, Kua, & Yap, 2009;Nilsson, Gustafson, & Hultberg, 2006;Robinson et al, 2011;Tiemeier et al, 2002).…”

Section: Vitamin B12mentioning

confidence: 99%

Nutritional predictors of depression in a cohort of community-dwelling elderly Canadians: NuAge cohort

GougeonLaura¹

2014

Appl. Physiol. Nutr. Metab.

View full text Add to dashboard Cite

Depression is associated with decreased quality of life and high mortality risk at all ages and, despite having lower prevalence in community-dwelling seniors compared to other stages of the life span or institutionalized elderly, it negatively affects seniors' health outcomes. Most evidence linking late-life depression, defined as first onset after 65 years of age, with dietary factors comes from cross-sectional studies, which cannot provide information on whether declines in diet were a consequence of depression-the reverse causality hypothesis. The Quebec Longitudinal Study on Nutrition and Aging (NuAge) provides an ideal setting to explore such a relationship among a healthy, community-dwelling elderly population. Diet is hypothesized to be a factor associated with depression. Some longitudinal evidence from studies with middle-aged adults suggests that dietary patterns such as the Mediterranean or patterns deemed "healthy" are protective against depression, while "western" and "unhealthy" patterns are risk factors for the disease. B-vitamins are important cofactors in neurotransmitter synthesis and in the enzymes of the one-carbon metabolism, which has been hypothesized to have an aetiological role in depression through its neurotoxic derivates, such as homocysteine. Nonetheless, it is still largely unknown how depression affects nutrient intake in the elderly population, raising the question of the directionality of the association. Therefore, ii the three objectives of this thesis were to explore the longitudinal associations of i) dietary patterns and macronutrient intake and of ii) B6, B12 and folate intakes with the incidence of depression in late life; and iii) to investigate whether depression significantly affects short-term nutrient intakes (reverse causality effect) in comparison to intakes among non-depressed seniors.Data for this study have been obtained from the NuAge cohort, a 4-y longitudinal study of 1,793 community-dwelling men and women aged 68 to 82 years at baseline. The main outcome is incidence of depression as defined by scores in the 30-item Geriatric Depression Scale ≥11 and or antidepressant medication use over the three years of follow-up. Participants were free of depression at the study's baseline through the exclusion of those with GDS scores ≥11 or antidepressant use at the time of the recruitment. Individuals with invalid or missing dietary information were also excluded. Dietary patterns were created through principal component analysis on amount (grams) of food items consumed in each of the 32 predefined food categories. Sex-specific tertiles of intake were created from the mean of three non-consecutive 24h-recalls. Multiple logistic regression models were adjusted for several demographic, health, and social confounders. For the study of the reverse causality hypothesis, we conducted a case-control nested within the NuAge cohort. Participants free of iii depression at baseline who developed depression at some point of follow-up were matched by age group and sex with...

show abstract

Section: Vitamin B12mentioning

confidence: 99%

Nutritional predictors of depression in a cohort of community-dwelling elderly Canadians: NuAge cohort

GougeonLaura¹

2014

Appl. Physiol. Nutr. Metab.

View full text Add to dashboard Cite

show abstract

“…It may be defined as the metabolic link in the pathogenesis of atherosclerotic vascular diseases and old-age dementia (Parnetti et al 1997). Both folate and vitamin B 12 are required in the methylation of homocysteine to methionine and in the remethylation and synthesis of S-adenosylmethionine (Bottiglieri, 1996;Parnetti et al 1997), a major methyl donor in the central nervous system. Vitamin B 6 in its active form pyridoxal phosphate, is a coenzyme of cystathionine synthase and cystathionine lyase.…”

Section: Homocysteine Folate Vitamin B 6 and Vitamin B 12mentioning

confidence: 99%

Nutrition and cognitive impairment in the elderly

Gross¹,

Marcos

Pietrzik³

2001

Br J Nutr

114

View full text Add to dashboard Cite

As the number of older people is growing rapidly worldwide and the fact that elderly people are also apparently living longer, dementia, the most common cause of cognitive impairment is getting to be a greater public health problem. Nutrition plays a role in the ageing process, but there is still a lack of knowledge about nutrition-related risk factors in cognitive impairment. Research in this area has been intensive during the last decade, and results indicate that subclinical deficiency in essential nutrients (antioxidants such as vitamins C, E and b-carotene, vitamin B 12 , vitamin B 6 , folate) and nutrition-related disorders, as hypercholesterolaemia, hypertriacylglycerolaemia, hypertension, and diabetes could be some of the nutrition-related risk factors, which can be present for a long time before cognitive impairment becomes evident.

show abstract

“…Several epidemiological studies have also suggested that hHcy may play a role in the cognitive performance (Prins ND, 2002) and pathophysiology of dementia in older people (Bell et al, 1992;Nilsson et al, 1996;Wahlin et al, 1996), possibly as the metabolic link between micro-vascular disease and old-age dementia (M.S. Morris et al, 2001;Parnetti et al, 1997). Feeding mice with a B-vitamin deficient diet for 10 weeks induced hHcy, significantly impaired learning and memory, and caused a significant rarefaction of hippocampal microvasculature unrelated to gliosis and neurodegeneration (Troen et al, 2008).…”

Section: Pathophysiological Mechanismsmentioning

confidence: 99%

“…Homocystein (Hcy) is an aminoacid entirely derived from the body's intermediary metabolism (Fekkes et al, 1998;Pietrzik & Bronstrup, 1997), which can be converted to either methionine or cysteine. Both folate and cobalamin participate in the methylation of Hcy to methionine and in the remethylation and synthesis of S-adenosylmethionine (Bottiglieri, 1996;Parnetti et al, 1997). The other metabolic pathway, which converts Hcy to cysteine requires the active form of vitamin B6 (pyridoxal phosphate) (Pietrzik & Bronstrup, 1997).…”

Section: Pathophysiological Mechanismsmentioning

confidence: 99%

“…Almost two-thirds of the prevalance of hHcy is attributable to low vitamin B status or intake (Selhub J, 2008). Although the catabolic rate of Hcy results from the interaction between genetic make-up and B vitamin status, it is generally accepted that elevated plasma Hcy concentrations are a sensitive marker for folate and cobalamin tissue deficiency (Bottiglieri, 1996;Joosten et al, 1993;Lokk, 2003;McCaddon et al, 1998;Nilsson et al, 1996;Nilsson et al, 1999;Parnetti et al, 1997). Folate and vitamin B12 are essential cofactors for the methionine/Hcy cycle in the brain.…”

Section: Pathophysiological Mechanismsmentioning

confidence: 99%

See 1 more Smart Citation