Role of Histaminergic System in Blood–Brain Barrier Dysfunction Associated with Neurological Disorders

Bañuelos-Cabrera, Ivette; Valle-Dorado, María Guadalupe; Aldana, Blanca I.; Orozco‐Suárez, Sandra; Rocha, Luisa

doi:10.1016/j.arcmed.2014.11.010

Cited by 25 publications

(12 citation statements)

References 146 publications

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“…A high level of histamine in the brain is associated with neuroinflammation, which is also observed in ASD and is predicted to be involved in the pathogenesis of many neurological diseases, including ASD. 10 , 65 Indeed TS may also have an inflammatory basis, as a recent study suggests enterovirus infection is associated with an increased incidence of Tic disorders; 66 and similar to ASD, 67 the incidence of allergies and asthma are strongly correlated with increased risk for TS. 68 Further research is required to determine what role the HS may or may not have in the enhanced neuroinflammation observed in each of these disorders.…”

Section: Discussionmentioning

confidence: 99%

Altered expression of histamine signaling genes in autism spectrum disorder

et al. 2017

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The histaminergic system (HS) has a critical role in cognition, sleep and other behaviors. Although not well studied in autism spectrum disorder (ASD), the HS is implicated in many neurological disorders, some of which share comorbidity with ASD, including Tourette syndrome (TS). Preliminary studies suggest that antagonism of histamine receptors 1–3 reduces symptoms and specific behaviors in ASD patients and relevant animal models. In addition, the HS mediates neuroinflammation, which may be heightened in ASD. Together, this suggests that the HS may also be altered in ASD. Using RNA sequencing (RNA-seq), we investigated genome-wide expression, as well as a focused gene set analysis of key HS genes (HDC, HNMT, HRH1, HRH2, HRH3 and HRH4) in postmortem dorsolateral prefrontal cortex (DLPFC) initially in 13 subjects with ASD and 39 matched controls. At the genome level, eight transcripts were differentially expressed (false discovery rate <0.05), six of which were small nucleolar RNAs (snoRNAs). There was no significant diagnosis effect on any of the individual HS genes but expression of the gene set of HNMT, HRH1, HRH2 and HRH3 was significantly altered. Curated HS gene sets were also significantly differentially expressed. Differential expression analysis of these gene sets in an independent RNA-seq ASD data set from DLPFC of 47 additional subjects confirmed these findings. Understanding the physiological relevance of an altered HS may suggest new therapeutic options for the treatment of ASD.

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Section: Discussionmentioning

confidence: 99%

Altered expression of histamine signaling genes in autism spectrum disorder

et al. 2017

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“…Mast cells play a relevant role in the pathogenesis of Alzheimer's disease. In fact, a large number of mast cells have been detected in the brains of Alzheimer patients [28]. In patients with Alzheimer's disease, mast cells migrate into the brain and play a significant role in the pathophysiology of the disease through the release of multiple mediators.…”

Section: Mast Cellsmentioning

confidence: 99%

“…In particular, 97% of mast cells are found in the perivascular zone of the microvasculature, while others are found in the brain parenchyma, leptomeninges, and choroid plexus. It has also been reported that mast cells form part of the neurovascular unit and are key players in the inflammatory response [28]. Neuroinflammation may contribute significantly to the pathogenesis of several neurodegenerative disorders including Alzheimer's disease.…”

Section: Mast Cellsmentioning

confidence: 99%

The Role of Mast Cells in Alzheimer’s Disease

Shaik-Dasthagirisaheb¹,

Conti²

2016

Adv Clin Exp Med

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“…Alterations in histaminergic pathways are known to have far-reaching consequences and it is therefore not surprising that histamine neurotransmission has been implicated in a number of neurological conditions [62][63][64][65][66]. For example, in post-mortem studies of patients with Alzheimer disease, levels of histamine were reduced in the hypothalamus, hippocampus and temporal lobes when compared to controls [67].…”

mentioning

confidence: 99%