Role of hippocampal neurogenesis in mnemonic segregation: implications for human mood disorders

Perera, Tarique D.; Thirumangalakudi, Lakshmi; Glennon, E.; Park, Sungshic; Insanally, Michele N.; Persky, Michael J.; Fonseka, Janaki; Dwork, Andrew J.; Sackeïm, Harold A.; Coplan, Jeremy D.; Fenton, André A.

doi:10.3109/15622975.2013.768356

Cited by 7 publications

(1 citation statement)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Perceptual segregation is the continuous segregation of multiple frames of reference, i.e., information streams where arena- and room-frames of reference are in continuous conflict (Abdel Baki et al, 2010). Mnemonic segregation has been tested in reversal modification with the need to segregate previous irrelevant memory for to-be-avoided zone from the new one (Perera et al, 2013). As mentioned before, the role of D2-like receptors in the flexibility of spatial avoidance behavior is an understudied phenomenon, which makes this task less comparable to other studies, but at the same time is capable of providing new insights into dopamine function in learning.…”

Section: Introductionmentioning

confidence: 99%

Spatial Reversal Learning in Chronically Sensitized Rats and in Undrugged Sensitized Rats with Dopamine D2-Like Receptor Agonist Quinpirole

Hatalova

Radostová

Pistikova

et al. 2014

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Dopamine plays a role in generating flexible adaptive responses in changing environments. Chronic administration of D2-like agonist quinpirole (QNP) induces behavioral sensitization and stereotypical behaviors reminiscent of obsessive–compulsive disorder (OCD). Some of these symptoms persist even after QNP discontinuation. In QNP-sensitization, perseverative behavior has often been implicated. To test the effect of QNP-sensitization on reversal learning and its association with perseveration we selected an aversively motivated hippocampus-dependent task, active place avoidance on a Carousel. Performance was measured as the number of entrances into a to-be-avoided sector (errors). We tested separately QNP-sensitized rats in QNP-drugged and QNP-undrugged state in acquisition and reversal tasks on the Carousel. In acquisition learning there were no significant differences between groups and their respective controls. In reversal, QNP-sensitized drugged rats showed a robust but transient increase in number of errors compared to controls. QNP-sensitized rats in an undrugged state were not overtly different from the control animals but displayed an altered learning manifested by more errors at the beginning compensated by quicker learning in the second session compared to control animals. Importantly, performance was not associated with perseveration in neither QNP-sensitized drugged nor QNP-sensitized undrugged animals. The present results show that chronic QNP treatment induces robust reversal learning deficit only when the substance is continuously administered, and suggest that QNP animal model of OCD is also feasible model of cognitive alterations in this disorder.

show abstract

Section: Introductionmentioning

confidence: 99%