Role of high dose vitamin C in management of hospitalised COVID-19 patients: A minireview

Juneja, Deven; Gupta, Anish; Sahil, Kataria; Singh, Omender

doi:10.5501/wjv.v11.i5.300

Cited by 3 publications

(2 citation statements)

References 52 publications

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“…Vitamin C, also known as ascorbic acid, is a water-soluble vitamin and is important for its immunological properties [ 26 ], its tissue regeneration effect due to collagen formation and its antioxidant properties. It is also essential for the primary prevention of various diseases, such as coronary heart disease, stroke, infections and cancer [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

ACE-Vitamin Index and Risk of Glaucoma: The SUN Project

et al. 2022

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Background: Previous studies regarding antioxidant consumption and glaucoma have shown contradictory results. The aim of this study was to analyze the combined effect of the consumption of three vitamins (A, C and E) on the incidence of glaucoma in the SUN Project. Methods: For this study, 18,669 participants were included. The mean follow-up was 11.5 years. An index including vitamins A, C and E (ACE-Vitamin Index) was calculated. Vitamin intake was extracted from participants’ dietary data and vitamin supplements, if taken. Information on glaucoma incidence was collected by previously validated self-reported questionnaires. The association between glaucoma and vitamin intake was assessed by repeated-measures Cox regression using multi-adjusted hazard ratios. Results: A total of 251 (1.3%) cases of glaucoma were detected. Participants with a higher ACE-Vitamin Index presented a reduced risk of glaucoma compared to participants with lower consumption (adjusted HR = 0.73; 95% CI, (0.55–0.98)). When each vitamin was analyzed individually, none of them had a significant protective effect. The protective effect of the ACE-Vitamin Index was higher in men and older participants (≥55 year). Conclusions: The consumption of vitamins A, C and E considered separately do not seem to exert a protective effect against glaucoma, but when these vitamins are considered together, they are associated with a lower risk of glaucoma.

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Section: Discussionmentioning

confidence: 99%

ACE-Vitamin Index and Risk of Glaucoma: The SUN Project

et al. 2022

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“…However, in clinical trials, where vitamin C has been investigated as an intervention for COVID-19, the results have not been encouraging. [12,[21][22][23][24] Much of the hype and hope surrounding free radicals and reactive oxygen species (ROS) stems from the article Aging: A Theory Based on Free Radical and Radiation Chemistry by Denham Harman. [8] Harman's paper is a landmark publication articulating the potential reactivity of ROS, however, it describes what reactions ROS can participate in but this does not necessarily translate into what reactions take place in vivo.…”

Section: Introductionmentioning

confidence: 99%

An Analysis of Antioxidant Therapies for COVID‐19

Holt,

Davies

2023

Advcd Theory and Sims

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Oxidative stress and inflammation are observed in critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). As oxidative stress is due to free radicals, free radical scavenging agents, such as vitamin C, are used in the hope of mitigating the severity of COVID‐19. In this paper an analytical model of free radical encounters within a cell is derived. It computes the effectiveness of free radical scavenging and the subsequent reduction in oxidative damage due to therapeutic intervention of exogenous antioxidants. Various publications make claims of success, albeit modest, treating critically ill COVID‐19 patients with high doses of vitamin C. The findings cast doubt on these claims and challenge the notion that any benefits attributed to vitamin C are due to free radical scavenging.

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Association of vitamins and minerals with COVID-19: A mini review

Mohammed,

Imran,

Rubat

2024

APJMBB

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19). SARS-CoV-2 has the potential to cause multiorgan failure (MOF), which is lethal. This review aims to evaluate the levels of some vitamins (vitamins C, A, D, and E) and minerals (zinc, iron, and selenium) in individuals infected with coronavirus. All studies reviewed indicate a deficiency in the minerals and vitamins mentioned above. We conclude that micronutrients play a significant role in the immune system and their deficiencies have a significant effect on the immune system. Although most antioxidants are believed to be present in diets, it has been suggested that taking more antioxidants will boost immunity. Although the immune system is constantly active, specific immunity is activated more when pathogens are present. The metabolites of vitamin A, D, and other nutrients control the expression of genes in immune cells.

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Role of high dose vitamin C in management of hospitalised COVID-19 patients: A minireview

Cited by 3 publications

References 52 publications

ACE-Vitamin Index and Risk of Glaucoma: The SUN Project

ACE-Vitamin Index and Risk of Glaucoma: The SUN Project

An Analysis of Antioxidant Therapies for COVID‐19

Association of vitamins and minerals with COVID-19: A mini review

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