Role of heme oxygenase-1 in tumor immune escape

Nitti, Mariapaola; Ortolan, Jasmin; Furfaro, Anna Lisa

doi:10.1530/rem-23-0006

Cited by 2 publications

(2 citation statements)

References 143 publications

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“…Priming signals also activate cellular stress response pathways involving heme oxygenase-1 (HO-1), which was shown to inhibit inflammasome activation ( 19 ). Heme oxygenases responsible for the degradation of heme groups into carbon monoxide, free ferrous iron, and biliverdin, are found in mammals in two different isoforms (HO-1 and HO-2) ( 20 ). The HO-3 isoform has also been described in rat; however, it was found to be encoded by pseudogenes derived from the HO-2 gene, and no functional HO-3 protein has been discovered ( 21 ).…”

Section: Introductionmentioning

confidence: 99%

“…The HO-3 isoform has also been described in rat; however, it was found to be encoded by pseudogenes derived from the HO-2 gene, and no functional HO-3 protein has been discovered ( 21 ). HO-2 is constitutively expressed and found mainly in the brain and testis, whereas HO-1 is a stress-inducible protein that shows a predominantly low level of expression when cells are at the resting stage; however, its expression increases dramatically in the presence of heavy metals, heme, cytokines, hormones, lipid metabolites, and changes in oxygen status ( 20 , 22 ). HO-1 is associated with the smooth endoplasmic reticulum, but is also present in the cell nucleus, mitochondria, and caveolae.…”

Section: Introductionmentioning

confidence: 99%

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Expression of a stress-inducible heme oxygenase-1 in NK cells is maintained in the process of human aging

Kaszubowska,

Kaczor,

Karnia

et al. 2024

Front. Immunol.

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IntroductionHeme oxygenase-1 (HO-1) is a stress-inducible heat shock protein (HSP32) that exerts cytoprotective effects against oxidative stress and inflammation, and is involved in the maintenance of cellular homeostasis. This study aimed to evaluate the expression of HO-1 in natural killer (NK) cells from individuals of different age groups after stimulation with various factors, and to analyze the relationships between the concentration of this cytoprotective protein and parameters corresponding to oxidative stress and inflammation, that is, NOD-like receptor protein 3 (NLRP3), glutathione (GSH), GSH disulfide (GSSG), and interleukin 6 (IL-6).MethodsThe study population comprised three age groups: young adults (age range, 19–23 years), older adults aged under 85 years (age range, 73–84 years), and older adults aged over 85 years (age range, 85–92 years). NLRP3, GSH, and GSSG concentrations were measured in serum, whereas the HO-1 concentration and IL-6 expression were studied in NK cells cultivated for 48 h and stimulated with IL-2, lipopolysaccharide (LPS), or phorbol 12-myristate 13-acetate (PMA) with ionomycin.ResultsThe analysis of serum NLRP3, GSH, and GSSG concentrations revealed no statistically significant differences among the studied age groups. However, some typical trends of aging were observed, such as a decrease in GSH concentration and an increase in both GSSG level, and GSSG/GSH ratio. The highest basal expression of IL-6 and lowest basal content of HO-1 were found in NK cells of adults over 85 years of age. The NK cells in this age group also showed the highest sensitivity to stimulation with the applied factors. Moreover, statistically significant negative correlations were observed between HO-1 and IL-6 expression levels in the studied NK cells.ConclusionsThese results showed that NK cells can express HO-1 at a basal level, which was significantly increased in activated cells, even in the oldest group of adults. The reciprocal relationship between HO-1 and IL-6 expression suggests a negative feedback loop between these parameters.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Expression of a stress-inducible heme oxygenase-1 in NK cells is maintained in the process of human aging

Kaszubowska,

Kaczor,

Karnia

et al. 2024

Front. Immunol.

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Heme Oxygenase-1 and Prostate Cancer: Function, Regulation, and Implication in Cancer Therapy

Salloom,

Ahmad,

Sahtout

et al. 2024

IJMS

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Prostate cancer (PC) is a significant cause of mortality in men worldwide, hence the need for a comprehensive understanding of the molecular mechanisms underlying its progression and resistance to treatment. Heme oxygenase-1 (HO-1), an inducible enzyme involved in heme catabolism, has emerged as a critical player in cancer biology, including PC. This review explores the multifaceted role of HO-1 in PC, encompassing its function, regulation, and implications in cancer therapy. HO-1 influences cell proliferation, anti-apoptotic pathways, angiogenesis, and the tumor microenvironment, thereby influencing tumor growth and metastasis. HO-1 has also been associated with therapy resistance, affecting response to standard treatments. Moreover, HO-1 plays a significant role in immune modulation, affecting the tumor immune microenvironment and potentially influencing therapy outcomes. Understanding the intricate balance of HO-1 in PC is vital for developing effective therapeutic strategies. This review further explores the potential of targeting HO-1 as a therapeutic approach, highlighting challenges and opportunities. Additionally, clinical implications are discussed, focusing on the prognostic value of HO-1 expression and the development of novel combined therapies to augment PC sensitivity to standard treatment strategies. Ultimately, unraveling the complexities of HO-1 in PC biology will provide critical insights into personalized treatment approaches for PC patients.

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Role of heme oxygenase-1 in tumor immune escape

Cited by 2 publications

References 143 publications

Expression of a stress-inducible heme oxygenase-1 in NK cells is maintained in the process of human aging

Expression of a stress-inducible heme oxygenase-1 in NK cells is maintained in the process of human aging

Heme Oxygenase-1 and Prostate Cancer: Function, Regulation, and Implication in Cancer Therapy

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