Role of helicobacter pylori infection in the incidence and clinical course of monoclonal gammopathy of undetermined significance

Malik, Azhar A.; Ganti, Apar Kishor; Potti, Anil; Levitt, Ralph; Hanley, James F.

doi:10.1016/s0002-9270(02)04024-8

Cited by 16 publications

(13 citation statements)

References 36 publications

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“…The observed link between MGUS and B‐cell lymphoproliferative disorders has triggered the search for H. pylori infection in patients diagnosed with MGUS. Moreover, eradication of H. pylori has been suggested for patients with MGUS [8]. However, there was no confirmation that MGUS resolved with anti‐ H. pylori therapy in a study involving 93 MGUS patients and 98 control subjects [30].…”

Section: Discussionmentioning

confidence: 99%

“…Infection by H. pylori has been linked to monoclonal gammopathy of undetermined significance (MGUS) [8]. Chronic antigenic stimulation and genetic susceptibility predispose to MGUS [9], which affects less than 5% of the population [10], and may precede multiple myeloma, plasma cell leukemia, or MALT lymphoma [11].…”

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confidence: 99%

“…Given an association between infection by H. pylori and MGUS, H. pylori eradication is a potential approach to preventing B‐cell lymphoproliferative disorders, for example, gastric MALT lymphoma. Indeed, Malik and colleagues report the resolution of MGUS and chronic gastritis in approximately one‐third of patients after H. pylori eradication [8].…”

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confidence: 99%

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Monoclonal Gammopathy of Undetermined Significance and Russell Body Formation in Helicobacter pylori Gastritis

et al. 2006

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This is the first report to demonstrate that upon infection with H. pylori, an impaired secretory capacity of plasma cells due to specific molecular changes can present as Russell body gastritis. The molecular findings question a pathogenetic link between Russell bodies and H. pylori, but suggest genetic alterations in the immunoglobulin locus as the possible cause for both MGUS and Russell body gastritis.

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Section: Discussionmentioning

confidence: 99%

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Monoclonal Gammopathy of Undetermined Significance and Russell Body Formation in Helicobacter pylori Gastritis

et al. 2006

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“…This group includes macroglobulinaemias accompanying other non‐Hodgkin and Hodgkin's lymphomas, and cases of autoimmune diseases, solid tumours, chronic liver and renal diseases, viral, bacterial and parasitic infections, septicaemia and polyneuropathy, which are accompanied by M proteinaemias (Andreone et al. , 1998; Schott, Pott & Ramadori, 1998; Markowitz, Zdunek & D'Agati, 2001; Malik et al. , 2002; Rajkumar et al.…”

Section: Introductionmentioning

confidence: 99%

Investigation of monoclonal gammopathy of undetermined significance: a single-centre study

et al. 2006

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Summary The main characteristic of monoclonal gammopathies (MG) is the presence of an increased amount of both electrophoretically and immunologically homogeneous immunoglobulins (M component). According to the WHO classification, monoclonal gammopathies are classified among the non-Hodgkin's lymphomas as 'plasma cell dyscrasias'. The unknown behaviour state, so-called MGUS (monoclonal gammopathy of undetermined significance), is distinguished from the malignant diseases. We investigated the frequency and features of MG and MGUS by reviewing the serum immunochemistry protein analyses between 1998 and 2004. Among 18,642 analyses, MG was found in 1,983 cases (10.39%) derived from one or more samples of 416 patients. Case histories of 340 patients were analysed. A malignant lymphoproliferative disease was proved in 171 cases, while in 169 cases the behaviour of the gammopathy was unknown. In 65 cases, the disease was possibly not related to MG. Mean follow-up time of the 65 patients with MGUS was 42 (9-81) months. During the follow-up period seven patients progressed into a malignant lymphoproliferative disorder-- mean probability of the malignant transformation was 3.07%/year and it occurred more frequently in the presence of immunoglobulin A isotype. There was no correlation between the progression of the disease and other laboratory findings. Besides the analyses of MG-related diseases, we focus on the malignant transformation of MGUS and on the importance of regular clinical and laboratory control examinations.

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“…Further proposed extragastric manifestations of H. pylori infection include monoclonal gammapathy of unknown significance (MGUS), in which the bacterium could be implicated, by provoking a chronic antigenic stimulation, at least in a portion of patients. A report points out a resolution of the gammapathy in 30% of MGUS subjects following H. pylori eradication [30], but another study conducted on a larger group of patients failed to find any evidence of remission of MGUS after antibacterial therapy [31].…”

Section: Helicobacter Pylori and Extragastric Diseasesmentioning

confidence: 99%

Helicobacter pylori and extragastric diseases – Other Helicobacters

et al. 2003

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The role of Helicobacter pylori infection is explored in more and more extragastric diseases without definite proof in most of the studies, except possibly some hematologic diseases. In cardiovascular diseases, including stroke, the presence of CagA positive strains may be involved. The possible role of helicobacters in hepatobiliary diseases goes beyond that of H. pylori to involve enterohepatic helicobacters. New Helicobacter species are regularly described and molecular methods are developed to improve their detection. Helicobacter felis remains the major species to be used in animal models of Helicobacter infection.

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Role of helicobacter pylori infection in the incidence and clinical course of monoclonal gammopathy of undetermined significance

Cited by 16 publications

References 36 publications

Monoclonal Gammopathy of Undetermined Significance and Russell Body Formation in Helicobacter pylori Gastritis

Monoclonal Gammopathy of Undetermined Significance and Russell Body Formation in Helicobacter pylori Gastritis

Investigation of monoclonal gammopathy of undetermined significance: a single-centre study

Helicobacter pylori and extragastric diseases – Other Helicobacters

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