Role of habituation and classical conditioning in the development of morphine tolerance.

Kesner, Raymond P.; Cook, David G.

doi:10.1037/0735-7044.97.1.4

Cited by 28 publications

(23 citation statements)

References 15 publications

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“…The demonstration of context-specific tolerance in the 48-h IDI, but not in the 12-h IDI, is consistent with other studies showing that a brief IDI attenuated tolerance controlled by contextual cues (Dafters & Odber, 1989;Kesner & Cook, 1983;Tiffany & Maude-Griffin, 1988;Tiffany et aI., 1991).…”

Section: Discussionsupporting

confidence: 90%

“…The second was to determine what effect relatively short intervals between morphine administrations would have on the acquisition (Experiment 1) and retention (Experiment 2) of context-specific withdrawal. Previous research has shown that a brief interdose interval (IDI) disrupts context-specific tolerance (Dafters & Odber, 1989;Kesner & Cook, 1983;Tiffany & Maude-Griffin, 1988;Tiffany, Maude-Griffin, & Drobes, 1991) but there have not been any studies examining the effect of this manipulation on withdrawal. The third goal was to determine whether both contextual withdrawal and tolerance were similarly affected by the IDI manipulation.…”

mentioning

confidence: 99%

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Context-specific morphine tolerance and withdrawal: The effects of interdose interval

1994

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Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 99%

Context-specific morphine tolerance and withdrawal: The effects of interdose interval

1994

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“…These results seem inexplicable according to the contextual-blocking hypothesis and have been thought to provide evidence in favour of an interpretation in terms of the development of non-associative tolerance. For example, tolerance to morphine in a novel context is generally described as associative, whereas tolerance in the home cages is often portrayed as non-associative (e.g., Kesner & Cook, 1983;Wolgin & Benson, 1991). However, when the role of injection cues has been investigated, the results support an associative interpretation of tolerance observed in home cages (Dafters & Bach, 1985;Cepeda-Benito & Tiffany, 1995).…”

Section: Discussionmentioning

confidence: 86%

The Role of Injection Cues in the Associative Control of the US Pre-Exposure Effect in Flavour Aversion Learning

Brugada

González

Cândido

2003

The Quarterly Journal of Experimental Psychology Section B

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Two experiments, using rats as subjects, examined the role of contextual cues in producing the unconditioned stimulus (US) pre-exposure effect in conditioned taste aversion. Experiment 1 showed a significant US pre-exposure effect, when the pre-exposure was conducted in a familiar context, and that a change of context between the pre-exposure and conditioning phases did not attenuate this effect. Experiment 2 demonstrated that extinction of injection-related cues after the pre-exposure stage attenuated the US pre-exposure effect, when the pre-exposure was conducted in either a familiar or a novel context. Taken together, these results support the associative explanation of the US pre-exposure effect in terms of blocking, incorporating a role for injection-related cues in the context blocking analysis of the US pre-exposure effect.

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“…There are many findings that support the conditioning analysis of tolerance (see reviews by Dworkin, 1993;Ramsay & Woods, 1997;Siegel, in press;Siegel & Allan, 1998). There also are contrary findings (e.g., Bardo & Hughes, 1979;Goudie & Griffiths, 1984;Kesner & Cook, 1983;LaHoste, Olson, Olson, & Kastin, 1980;Tiffany & Maude-Griffin, 1988). The purpose of these experiments was to investigate a basis for the discrepant findings.…”

mentioning

confidence: 96%

Drug-onset cues as signals: Intraadministration associations and tolerance.

Kim¹,

Siegel²,

Patenall³

1999

Journal of Experimental Psychology: Animal Behavior Processes

109

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On the basis of a conditioning analysis of drug tolerance, drug-associated cues become associated with the drug effect. These cues elicit conditional compensatory responses and modulate the expression of tolerance. Although there are many findings consistent with the conditioning analysis of tolerance, there also are contrary findings. The results of these experiments suggest that some of the apparently contradictory findings result because interoceptive pharmacological cues, as well as exteroceptive environmental cues, are paired with a drug effect. That is, within each administration, early drug-onset cues may become associated with the later, larger drug effect, and these pharmacological cues may overshadow simultaneously present environmental cues. We demonstrate the contribution of such intraadministration associations to tolerance to the analgesic effect of morphine and to the expression of conditional compensatory hyperalgesia.

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Role of habituation and classical conditioning in the development of morphine tolerance.

Cited by 28 publications

References 15 publications

Context-specific morphine tolerance and withdrawal: The effects of interdose interval

Context-specific morphine tolerance and withdrawal: The effects of interdose interval

The Role of Injection Cues in the Associative Control of the US Pre-Exposure Effect in Flavour Aversion Learning

Drug-onset cues as signals: Intraadministration associations and tolerance.

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