Role of gut microbiota in epigenetic regulation of colorectal Cancer

Zhao, Yinghui; Wang, Chuanxin; Goel, Ajay

doi:10.1016/j.bbcan.2020.188490

Cited by 33 publications

(20 citation statements)

References 164 publications

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“…The past decade has witnessed critical contributions of gut microbiome research to both autoimmune disorders of the gut, such as inflammatory bowel disease 28 , as well as a wide range of psychological 29 , metabolic 30 , and neoplastic diseases [31][32] . However, less attention has been paid to the potential role of gut microbiota in the pathogenesis of HAE.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiome alterations in hereditary angioedema

Cao

Kan

Wang

et al. 2022

Annals of Allergy, Asthma & Immunology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Discussionmentioning

confidence: 99%

Gut microbiome alterations in hereditary angioedema

Cao

Kan

Wang

et al. 2022

Annals of Allergy, Asthma & Immunology

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“…Colorectal cancer is the frequent cancer globally and has high mortality and incidence rates ( Wieszczy et al, 2020 ; Świerczyński et al, 2021 ; Zaborowski et al, 2021 ; Zhao et al, 2021 ). Bi et al (2020) revealed that LINC01116 was highly expressed in CRC tissues compared to normal tissues, and patients with high expression of LINC01116 had a very poor prognosis.…”

Section: Expression and Clinical Characteristics Of Linc01116 In Various Cancer Typesmentioning

confidence: 99%

Promising Advances in LINC01116 Related to Cancer

Xu¹,

Yu²,

Zhang³

et al. 2021

Front. Cell Dev. Biol.

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Long non-coding RNAs (lncRNAs) are RNAs with a length of no less than 200 nucleotides that are not translated into proteins. Accumulating evidence indicates that lncRNAs are pivotal regulators of biological processes in several diseases, particularly in several malignant tumors. Long intergenic non-protein coding RNA 1116 (LINC01116) is a lncRNA, whose aberrant expression is correlated with a variety of cancers, including lung cancer, gastric cancer, colorectal cancer, glioma, and osteosarcoma. LINC01116 plays a crucial role in facilitating cell proliferation, invasion, migration, and apoptosis. In addition, numerous studies have recently suggested that LINC01116 has emerged as a novel biomarker for prognosis and therapy in malignant tumors. Consequently, we summarize the clinical significance of LINC01116 associated with biological processes in various tumors and provide a hopeful orientation to guide clinical treatment of various cancers in future studies.

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“…About 10 [11][12] bacteria colonize in the human colon, of which over 90% belong to Bacterioides and Firmicutes. In the intestinal microbiota of infant with cholestasis, we saw a signi cantly reduced relative abundance of Bacterioides and Firmicutes (BA group, 34.31%; CD group, 50.00%) and a marked increase in the proportion of Proteobacteria (BA group, 58.87%; CD group, 39.44%).…”

Section: Discussionmentioning

confidence: 99%

“…Gut microbiome have been found to be closely associated with multiple diseases such as obesity [8], osteoporosis [9], diabetes [10], Alzheimer's disease [11], gastrointestinal cancer [12], and in ammatory bowel disease [13]. More importantly, it has been shown that gut microbiome is involved in the occurrence and development of hepatobiliary diseases.…”

Section: Introductionmentioning

confidence: 99%

The difference of gut microbiome in different biliary diseases in infant before operation and the changes after operation

Sun

Cai

Dai

et al. 2022

Preprint

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Background Evidence supports an association between cholestatic liver disease and changes in microbiome composition. Nevertheless, the identification of this special type of biliary atresia from non-biliary atresia cholestasis is still a major clinical difficulty. The purpose of this study is to compare the differences in the composition of gut microbiome between infants with biliary atresia and infant with non-biliary atrestic cholestasis, to find new ways to identify and diagnose these two diseases early, to understand the influence of the presence or absence of bile on the composition of the gut microbiome in infants with cholestasis. Methods Using 16S rDNA gene sequencing technology to analyze the intestinal flora of the participants. Results In terms of diversity, there is an obvious structural separation in the intestinal microbiota of the BA group and the CD group, and this structural separation also exists in the comparison between the two groups before surgery. Species analysis demonstrated that the two groups showed an increase in Proteobacteria and Firmicutes before surgery, and the relative abundance of pathogens such as Shigella, Streptococcus, Klebsiella, etc. increased, probiotics such as Bifidobacteria and Lactobacillus decreased, but the relative abundance of each genus was different between groups. It was found that Enterococcus, Ralstonia, Nitriliruptoraceae, etc. were differentially enriched in the BA group, the CD group are mainly enriched in Veillonella, Clostridium_sensu_stricto_1 and Lactobacillus. Functional analysis of the groups showed that the BA group mainly focused on the processes of energy release processes, and the CD group mainly focused on the biosynthesis of amino-acids to consume energy. Conclusions The composition of intestinal flora is different between biliary atresia and non-biliary atretic cholestasis. Enterococcus, Ralstonia, etc. may become biomarkers for the identification and diagnosis of both.

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Role of gut microbiota in epigenetic regulation of colorectal Cancer

Cited by 33 publications

References 164 publications

Gut microbiome alterations in hereditary angioedema

Gut microbiome alterations in hereditary angioedema

Promising Advances in LINC01116 Related to Cancer

The difference of gut microbiome in different biliary diseases in infant before operation and the changes after operation

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