Role of GM3 ganglioside in the pathology of some progressive human diseases and prognostic importance of serum anti-GM3 antibodies

Kolyovska, Vera; Ivanova, Sonya; Drenska, Desislava; Maslarov, Dimitar; Toshkova, Reneta

doi:10.32604/biocell.2021.016250

Cited by 2 publications

(2 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diseases as epilepsy, Parkinson's disease, Huntington's disease, and melanoma may include impaired ganglioside metabolism [8,9,12]. The accumulation of GM2 and GM3 ganglioside types has been proposed as indicative of a mechanism of interactions between stroke, AD and other neurodegenerative diseases and disorders in vitro and in rat models [1].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Can Serum IgG Antiganglioside Antibodies to GM1, GM3 and GD1a be Used as Markers in Patients with Ischemic Stroke?

Kolyovska¹,

Drenska²,

Maslarov³

2022

AMA

View full text Add to dashboard Cite

Our aim is to verify whether serum IgG antiganglioside antibodies (anti-GM1, anti-GD1a and anti-GM3) can be used as markers for patients with ischemic stroke. We showed the results of the antibody titer obtained by ELISA technique. There were 21 sera from patients under 75 years of age with ischemic strokes received between 2017-2020 from University First MHAT -Sofia, "St. John Krastitel". Three patients had a very weak indication for demyelination. Five had indication that correlates with possible metabolic abnormalities. The conclusion that could be drawn was that the antiganglioside antibodies titer was not decisive and could not be used as biomarker in stroke patients, and did not directly correlate with stroke severity, size of the ischemic area (reported by computed tomography data), and likely recovery prognosis. In ischemic strokes none of the patients had an indication of neuronal damage, as in the case with severe attacks of multiple sclerosis or Alzheimer's disease.

show abstract

Section: Resultsmentioning

confidence: 99%

“…The expression patterns of gangliosides vary in different tissues, during different life periods, as well as in various pathologies [1,9,11,12]. The antiganglioside antibodies (AGAs) have the potential to be suitable diagnostic and therapeutic biomarkers for many brain abnormalities [14].…”

Section: Introductionmentioning

confidence: 99%