Role of glutathione S-transferases in melanoma susceptibility: association with GSTP1 rs1695 polymorphism

Ibarrola‐Villava, Maider; Martín-González, Manuel; Lázaro, Pablo; Pizarro, Ángel; Lluch, Aña; Ribas, Gloría

doi:10.1111/j.1365-2133.2012.10831.x

Cited by 38 publications

(40 citation statements)

References 38 publications

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“…The rs1695 polymorphism of GSTP1 can cause Ile at amino acid number 105 of GSTP1 to mutate to Val leading to reduced activity of the GSTP1 protein, which also affects susceptibility to lung cancer (Ibarrola-Villava et al, 2012). That particular polymorphism is most prevalent in African-Americans, followed by Caucasians and Asians (Hezova et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Correlation between gene polymorphisms of CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 and susceptibility to lung cancer

Liu

2016

Genet. Mol. Res.

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ABSTRACT. Lung cancer is a common malignant tumor that is characterized by high morbidity and poor prognosis. Studies suggest that an individual's genetic background affects the risk of developing lung cancer. Therefore, we investigated the relationship between gene polymorphisms and susceptibility to lung cancer. We recruited 308 primary lung cancer patients as subjects and 253 healthy adults as controls. After extraction of DNA from blood samples, gene polymorphisms in CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 were investigated by polymerase chain reaction and restriction fragment length polymorphism. The frequencies of the genotypes in both groups were investigated to obtain odds ratios and 95% confidence intervals, and correlation analysis was carried out. The analysis results showed that the following polymorphisms were correlated with susceptibility to lung cancer: rs4646903 in CYP1A1 (P < 2 H.X. Liu et al.Genetics and Molecular Research 15 (4): gmr15048813 0.001), rs1048943 in CYP1A1 (P < 0.001), rs1695 in GSTP1 (P < 0.05), rs13181 in ERCC2 (P < 0.001), and rs25487 in XRCC1 (P < 0.05); no such correlation existed in rs861539 in XRCC3 (P > 0.05). The study revealed that the more high-risk gene polymorphisms a patient carries, the greater the risk of developing lung cancer. Carriers of rs4646903 in CYP1A1, rs1048943 in CYP1A1, rs1695 in GSTP1, rs13181 in ERCC2, and rs25487 in XRCC1 are more likely to develop lung cancer.

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Section: Discussionmentioning

confidence: 99%

Correlation between gene polymorphisms of CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 and susceptibility to lung cancer

Liu

2016

Genet. Mol. Res.

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“…Over the past decades, a number of studies were conducted to investigate the association between GSTP1 Ile105Val polymorphism and skin cancer risk in humans [3,4,7,9,16,21,23,25,27,28,31]. However, the results of these studies were conflicting and inconclusive, which could be due to the insufficient statistical power.…”

Section: Introductionmentioning

confidence: 96%

Association of glutathione S-transferase pi (GSTP1) Ile105Val polymorphism with the risk of skin cancer: a meta-analysis

Zhou

et al. 2015

Arch Dermatol Res

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Numerous epidemiological studies have evaluated the association of Glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism with the risk of skin cancer. However, the results remain inconclusive. To derive a more precise estimation of the association between the GSTP1 Ile105Val polymorphism and skin cancer risk, a meta-analysis was performed. A comprehensive search was conducted to identify the eligible studies. We used odds ratios (ORs) with 95 % confidence intervals (CIs) to assess the association of GSTP1 Ile105Val polymorphism with skin cancer risk. Thirteen case-control studies in nine articles, which included a total of 1504 cases and 2243 controls. Overall, we found that GSTP1 Ile105Val polymorphism was not associated with skin cancer risk. Furthermore, subgroup analysis by histological types showed that GSTP1 Ile105Val polymorphism was associated with risks of malignant melanoma under the dominant model (Val/Val + Val/Ile vs. Ile/Ile: OR 1.230, 95 % CI 1.017-1.488, P = 0.033). However, lack of association between GSTP1 Ile105Val polymorphism and BCC and SCC risk in all genetic models. Our meta-analysis suggested that the GSTP1 Ile105Val polymorphism might be associated with increased risk of malignant melanoma in Caucasian population.

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“…These results suggested that the G/G genotype was a risk for the development of ALL and AML factor was also associated with poor prognosis (Dunna et al 2012). Ibarrola-Villava et al (2012) analyzed the samples from 562 Spanish patients with sporadic malignant melanoma (MM) and 338 cancer-free control. This was the first time that the GSTP1 rs1695 polymorphism was reported to be associated with MM.…”

Section: Resultsmentioning

confidence: 99%

“…This was the first time that the GSTP1 rs1695 polymorphism was reported to be associated with MM. In addition, this study was one of the largest GST polymorphism studies undertaken in the Spanish population and the first time that copy number variants were scrutinized in relation to MM (Ibarrola-Villava et al 2012). The analysis of SNPs rs1695 and rs2853676 of GSTP1 and Telomerase Reverse Transcriptase (TERT) genes respectively in 301 samples and 302 control samples Gliomas in Chinese patients showed a positive association for susceptibility to develop this neoplasm, therefore, could be considered risk factors for development gliomas (Li et al 2012).…”

Section: Resultsmentioning

confidence: 99%

Dideoxy single allele-specific PCR - DSASP new method to discrimination allelic

Lima

Lopes²,

Soares

et al. 2015

Braz. arch. biol. technol.

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Role of glutathione S-transferases in melanoma susceptibility: association with GSTP1 rs1695 polymorphism

Abstract: This is the first time that the GSTP1 rs1695 polymorphism is reported to be associated with MM. In addition, this study is one of the largest GST polymorphism studies undertaken in the Spanish population and the first time that copy number variants have been scrutinized in relation to MM.

Cited by 38 publications

References 38 publications

Correlation between gene polymorphisms of CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 and susceptibility to lung cancer

Correlation between gene polymorphisms of CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 and susceptibility to lung cancer

Association of glutathione S-transferase pi (GSTP1) Ile105Val polymorphism with the risk of skin cancer: a meta-analysis

Dideoxy single allele-specific PCR - DSASP new method to discrimination allelic

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