Correlation between gene polymorphisms of CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 and susceptibility to lung cancer

Abstract

ABSTRACT. Lung cancer is a common malignant tumor that is characterized by high morbidity and poor prognosis. Studies suggest that an individual's genetic background affects the risk of developing lung cancer. Therefore, we investigated the relationship between gene polymorphisms and susceptibility to lung cancer. We recruited 308 primary lung cancer patients as subjects and 253 healthy adults as controls. After extraction of DNA from blood samples, gene polymorphisms in CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 were investigated by polymerase chain reaction and restriction fragment length polymorphism. The frequencies of the genotypes in both groups were investigated to obtain odds ratios and 95% confidence intervals, and correlation analysis was carried out. The analysis results showed that the following polymorphisms were correlated with susceptibility to lung cancer: rs4646903 in CYP1A1 (P < 2 H.X. Liu et al.Genetics and Molecular Research 15 (4): gmr15048813 0.001), rs1048943 in CYP1A1 (P < 0.001), rs1695 in GSTP1 (P < 0.05), rs13181 in ERCC2 (P < 0.001), and rs25487 in XRCC1 (P < 0.05); no such correlation existed in rs861539 in XRCC3 (P > 0.05). The study revealed that the more high-risk gene polymorphisms a patient carries, the greater the risk of developing lung cancer. Carriers of rs4646903 in CYP1A1, rs1048943 in CYP1A1, rs1695 in GSTP1, rs13181 in ERCC2, and rs25487 in XRCC1 are more likely to develop lung cancer.

Association of 12 polymorphic variants conferring genetic risk to lung cancer in Indian population: An extensive meta‐analysis

“…The SNP rs1048943 of CYP1A1 was found to be associated with lung cancer in East Asians [Liu et al, ], which shows colinearity of our finding on Indian population to that of East Asian population. The CYP1A1 (Cytochrome P450; 15q22–24) gene encodes a key phase I endoplasmic and cytosolic xenobiotic metabolism enzyme, present in lung tissue.…”

<p>Association of <em>XRCC1</em>, <em>XRCC2</em> and <em>XRCC3</em> Gene Polymorphism with Esophageal Cancer Risk</p>

“…Variation in expression of XRCC3 has been reported in various cancers, like gastric, breast, lung, skin and colorectal. [18][19][20][21] The most common polymorphism in XRCC3 p.Thr241Met in exon 7 can influence the ability to repair DNA. 21 Allelic variants of XRCC1, XRCC2, and XRCC3 are associated with risk of different types of cancer among different populations all over the world.…”

“…[18][19][20][21] The most common polymorphism in XRCC3 p.Thr241Met in exon 7 can influence the ability to repair DNA. 21 Allelic variants of XRCC1, XRCC2, and XRCC3 are associated with risk of different types of cancer among different populations all over the world. [22][23][24] In the world's second-most populous country India, the large and diverse ethnic subpopulations 25 need to be studied to understand the genetic basis of several region-specific complex disorders.…”

The impacts of genetic polymorphisms in genes of base excision repair pathway on the efficacy and acute toxicities of (chemo)radiotherapy in patients with nasopharyngeal carcinoma

“…BER pathway gene polymorphisms were reported to be related to the oncogenesis [ 21 – 23 ]. Recent studies also showed that the mutation of BER pathway genes could increase the radiosensivity by reducing the DNA repair ability [ 24 ].…”