Role of gene regulation and inter species interaction as a key factor in gut microbiota adaptation

Simulate the Dynamic Interactions Across Nutritional Supplements, the Polybiome, and the Biochemical Approach Dependent on Patient-Derived Gastrointestinal Knowledge

“…Though we are starting to comprehend the complicated connection between the gut polybiome and these pathogenic species, concerns remain concerning the roles that eating habits, endophytic microbial biodiversity in the human gut, and anabolic-neuro-biochemical networks of microbial populations in the intestines play in maintaining tissue homeostasis and physiological processes inside a bodily organ. And this is the first evidence that the microbiota in the midgut is endophytic, as De Barry (1866) stated in his description of endophytic [30][31][32][33][34][35][36][37][38][39][40]. Since then, the term has been entrenched in the publishing industry and is no longer limited to agricultural uses.…”

The connection between epigenetics and gut microbiota‐current perspective

“…The metabolites of these microbes through inflammations such as neuroinflammation, cytokine storm syndrome, amyloid deposition, altered N ‐methyl‐ d ‐aspartate and brain‐derived neurotrophic factor play a crucial role in pathogenesis of AD 84 . The aberrant epigenetic alterations and the imbalance GM aid in the initiation of CRC 85,86 . The genetic expression is switched to an alternative pathway through the alteration of GM 87 .…”

“…84 The aberrant epigenetic alterations and the imbalance GM aid in the initiation of CRC. 85,86 The genetic expression is switched to an alternative pathway through the alteration of GM. 87 GM has been widely studied to be part of the pathophysiology of many diseases.…”

Yeast cell-wall polysaccharides improve immunity and attenuate inflammatory response via modulating gut microbiota in LPS-challenged laying hens

“…Intestinal microenvironmental homeostasis plays a functional role in inhibiting the colonization of pathogenic organisms, maintaining intestinal epithelial integrity and modulating mucosal and innate immunity in the host [22]. This homeostasis is attributed to the maintenance of a certain proportion of microbiota and their remarkable influence on genetic regulation [23]. Numerous studies have shown that genetic regulation is an important way for gut microbial metabolites to affect host health and immunity [24][25][26].…”

“…Numerous studies have shown that genetic regulation is an important way for gut microbial metabolites to affect host health and immunity [24][25][26]. On the other hand, gut microbiota could also alter their gene expression to adapt to the changed conditions or diets [23]. Hence, deciphering gut microbial composition may provide useful insights into the potential impacts of its manipulation by dietary intervention on the immune status and intestinal health of the host.…”