Yeast cell-wall polysaccharides improve immunity and attenuate inflammatory response via modulating gut microbiota in LPS-challenged laying hens

Zhou, Jian‐Min; Fu, Yu; Qi, Guang‐hai; Dai, Jinjun; Zhang, Haijun; Wang, Jing; Wu, Shu‐geng

doi:10.1016/j.ijbiomac.2022.10.133

Cited by 11 publications

(4 citation statements)

References 73 publications

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“…The liver is a central organ for the metabolism of various tissues. Through functions such as bile secretion, protein metabolism, carbohydrate metabolism and lipid metabolism, it helps the body digest, absorb nutrients and maintain metabolic balance [63] . Based on the DEMs, the analysis of potential metabolic pathways was measured, which was helpful in revealing the mechanism of different RFI groups.…”

Section: Discussionmentioning

confidence: 99%

In-depth investigation of the mechanisms of high and low residual feed intake regulating hens during the late laying period via liver and gut microbiota

Gao,

Zheng,

Mao

et al. 2024

Preprint

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The RFI is independent of growth traits and selecting individuals with low RFI can improve feed efficiency without affecting the laying performance and egg quality of hens. In this study it was found that under similar egg production rates hens in the HRFI group had lower nutrient digestion capacity disrupted lipid metabolism and lower feed utilization efficiency than those in the LRFI group. Further research and validation are needed to investigate the effects of AST HDL-C and ACTH on feed efficiency in the late laying period through serum biochemical index analysis. Through multiomics analysis genes such as ADCY2 ADCY8 CCKAR ACSS2 FABP1 and FABP4 and metabolites such as LysoPI(18:2(9Z,12Z)/0:0) were identified as key genes and biomarkers related to RFI in laying hens during the late laying period. These findings are important for developing strategies to improve feed efficiency in Rhode Island Red pure-line chickens during the late laying period. Additionally in-depth investigations such as histological observations enzyme activity analysis and integration of multiomics techniques are needed to unravel the physiological and biochemical mechanisms of digestive organs that impact feed utilization efficiency in poultry.

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Section: Discussionmentioning

confidence: 99%

In-depth investigation of the mechanisms of high and low residual feed intake regulating hens during the late laying period via liver and gut microbiota

Gao,

Zheng,

Mao

et al. 2024

Preprint

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“…Jensen et al ‘s study showed an anti-inflammatory effect of the XP yeast culture in conjunction with activation of NK cells and B lymphocytes in vitro ( Jensen et al, 2008 ). Jianmin Zhou et al ‘s study provided that dietary yeast cell wall polysaccharides alleviated the LPS-induced elevated levels of serum IL-6 and IL-1β and the up-regulated expression of IL-1β, TNF-α, IFN-γ, and IL-6 in spleen and/or ileal mucosa ( Jianmin Zhou et al, 2023 ). Nevertheless, YP could relieve inflammation of the intestine in PEDV-infected piglets.…”

Section: Discussionmentioning

confidence: 99%

Effect of supplementation with yeast polysaccharides on intestinal function in piglets infected with porcine epidemic diarrhea virus

Li,

Wu,

et al. 2024

Front. Microbiol.

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Porcine epidemic diarrhea virus (PEDV) has caused huge economic losses to the pig industry. Yeast polysaccharides (YP) has been used as a feed additive in recent years and poses good anti-inflammatory and antiviral effects. The present study aimed to explore the protective effect of YP on intestinal damage in PEDV-infected piglets. Eighteen 7-day-old piglets with similar body weights were randomly divided into three groups: Control group (basal diet), PEDV group (basal diet), and PEDV+YP group (basal diet +20 mg/kg BW YP), six replicates per group and one pig per replicate. Piglets in PEDV group and PEDV+YP group were orally given PEDV (dose: 1 × 106 TCID50) at 19:30 PM on the 8th day of the experiment. The control group received the same volume of PBS solution. Weight was taken on an empty stomach in the morning of the 11th day, blood was collected and then anesthetic was administered with pentobarbital sodium (50 mg/kg·BW) by intramuscular injection, and samples were slaughtered after the anesthetic was complete. The results showed that YP could alleviate the destruction of intestinal villus morphology of piglets caused by PEDV. Meanwhile, PEDV infection can reduce the activity of glutathione peroxidase, superoxide dismutase and catalase, and increase the content of malondialdehyde. YP can improve the antioxidative capacity in the serum and small intestine of PEDV-infected piglets. In addition, YP inhibited the replication of PEDV in the jejunum ileum and colon. Moreover, YP can regulate the mRNA levels of inflammatory genes (IL-1β and iNOS) and lipid metabolic genes (APOA4 and APOC3) in the small intestine. In summary, YP could inhibit virus replicates, improve intestinal morphology, enhance antioxidant capacity, relieve inflammation and regulate the metabolism of the intestine in PEDV-infected piglets.

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“…This enables researchers to collect samples without troubling the microbiota and to diminish stress on the chickens 41 . A greater understanding of the role of feed additives such as prebiotics on the microbial population and their diversity in response to HS could aid in the development of focused approaches to HS relief 2 , 42 . High throughput sequencing was used to estimate the gut microbiota and their microecological composition in poultry 16 , 43 .…”

Section: Discussionmentioning

confidence: 99%

Prophylactic influences of prebiotics on gut microbiome and immune response of heat-stressed broiler chickens

Sayed,

Hassan,

Salem

et al. 2023

Sci Rep

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Climatic changes and elevated ambient temperature are significant environmental stressors with a negative impact on birds’ physiological, immunological, and behavioral status, increasing their susceptibility to stressors and immunosuppression and consequently increasing intestinal permeability (leaky gut). Prebiotics have been utilized to stop or diminish the harmful effects of stress in chickens. We aimed to evaluate the role of mannan-oligosaccharides, and beta-d-glucan prebiotics supplements in drinking water against experimentally induced heat stress (HS) on broiler chickens and study their impact on birds’ performance, gut microbiome, and immune response. A total of 120 1-day-old Ross broiler chicks were allocated into four groups (30 birds/group), and each group was subdivided into triplicates (10 birds each). The experimental groups were classified as follows; the 1st (G1) control birds, the 2nd (G2) birds exposed experimentally to HS, the 3rd (G3) birds administered prebiotics in drinking water without exposure to HS, and the 4th (G4) birds exposed to HS and administered prebiotics in drinking water. After each vaccination, blood samples and serum samples were collected to evaluate the birds’ immune status. Fecal samples were also collected for the molecular evaluation of the gut microbiome based on the genetic analyses and sequencing of 16S rRNA gene. The results showed that HS has reduced the birds’ performance and badly affected the birds’ immune response and gut microbiome. However, the addition of prebiotics to drinking water, with or without stress, enhanced the growth rate, maintained a normal gut microbiome, and improved immune parameters. Moreover, the usage of prebiotics improved the chicken gut microbiome and alleviated the negative effect of heat stress. Administering prebiotics significantly (p < 0.05) increased the relative abundance of beneficial bacteria and eradicated pathogenic ones in the birds’ gut microbiome. Prebiotics showed a positive effect on the gut microbiome and the immune status of chickens under HS in addition to their efficacy as a growth promoter.

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Yeast cell-wall polysaccharides improve immunity and attenuate inflammatory response via modulating gut microbiota in LPS-challenged laying hens

Cited by 11 publications

References 73 publications

In-depth investigation of the mechanisms of high and low residual feed intake regulating hens during the late laying period via liver and gut microbiota

In-depth investigation of the mechanisms of high and low residual feed intake regulating hens during the late laying period via liver and gut microbiota

Effect of supplementation with yeast polysaccharides on intestinal function in piglets infected with porcine epidemic diarrhea virus

Prophylactic influences of prebiotics on gut microbiome and immune response of heat-stressed broiler chickens

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