Role of gallium 67 in inflammatory disease

Staab, Edward V.; McCartney, William

doi:10.1016/s0001-2998(78)80030-0

Cited by 117 publications

(23 citation statements)

References 25 publications

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“…Accumulation in sterile inflamma tory lesions has also been reported after administration of other radio pharmaceuticals such as Ga-67 and labeled WBC scintigraphy (11)(12)(13).…”

Section: Discussionmentioning

confidence: 85%

Diagnosis of bone, joint, and joint prosthesis infections with In-111-labeled nonspecific human immunoglobulin G scintigraphy.

Oyen¹,

Horn²,

Claessens³

et al. 1992

Radiology

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“…Accumulation in sterile inflamma tory lesions has also been reported after administration of other radio pharmaceuticals such as Ga-67 and labeled WBC scintigraphy (11)(12)(13).…”

Section: Discussionmentioning

confidence: 85%

Diagnosis of bone, joint, and joint prosthesis infections with In-111-labeled nonspecific human immunoglobulin G scintigraphy.

Oyen¹,

Horn²,

Claessens³

et al. 1992

Radiology

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“…The diagnostic application of gallium-67 has several inherent disadvantages that make it less than ideal in imaging the chest: 1) there is a prolonged delay (usually 72 h), from the time of injection to the time of diagnostic imaging to allow gallium to be cleared from the blood pool; 2) the relatively large photon energy of gallium (6-7 mCi) exposes the patient and hospital personnel to a relatively large dose of radiation (total body=1.64 rads); 3) it prevents the performance of subsequent nuclear studies for 10-14 days; and 4) it limits studies to the use of stationary cameras. Therefore, in contrast to gallium, nuclear imaging using thallium offers several advantages: 1) immediate imaging; 2) the much lower photon energy of thallium (2-3 mCi) exposes the patient and hospital personnel to less radiation (total body=0.69 rads); 3) the ability to perform subsequent nuclear studies immediately; 4) the potential for the use of a portable camera facilitates its use in a critical care setting; 5) facilitation of out-patient testing since it can be completed on a single visit; 6) no potential loss of sensitivity, as with gallium in the presence of leucopenia [19]; and 7) greater sensitivity than gallium in inflammatory lung diseases [11].…”

Section: Discussionmentioning

confidence: 99%

“…The value of a sensitive noninvasive technique is further enhanced by the observation that acute rejection episodes may remain clinically silent [19]. Rejection has been reported in up to 39% of surveillance biopsies performed in the absence of clinical or physiological decline [9].…”

Section: Discussionmentioning

confidence: 99%

Thallium-201 scintigraphy in the evaluation of graft dysfunction in lung transplantation. Newark Beth Israel Medical Center Lung Transplant Group

Rr²,

Ma³

1996

Eur Respir J

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T Th ha al ll li iu um m--2 20 01 1 s sc ci in nt ti ig gr ra ap ph hy y i in n t th he e e ev va al lu ua at ti io on n o of f g gr ra af ft t d dy ys sf fu un nc ct ti io on n i in n l lu un ng g t tr ra an ns sp pl la an nt ta at ti io on n ABSTRACT: The object of this study was to evaluate graft dysfunction utilizing thallium-201 scintigraphy in patients who had undergone lung transplantation.We studied 11 patients who had undergone single-lung transplantation and had 44 evaluations for suspected graft dysfunction. All evaluations included a lung thallium-201 scan and chest radiography. In addition, 42 transbronchial biopsies, 19 gallium-67 scans and 28 pulmonary function tests were obtained. Rejection was defined by histopathology and/or the response to an empirical pulse of methylprednisolone, while cultures of protected specimen brushes and blood with a positive chest radiograph were used to define infection.The sensitivity of thallium scintigraphy for diagnosing rejection and/or infection (94%) was higher than that for transbronchial biopsy (86%), gallium scintigraphy (47%), chest radiography (67%), or spirometry testing (30%). Specificity was 100% for thallium scintigraphy and transbronchial biopsy, as compared to chest radiography and spirometry, which were 75 and 80% respectively. This study indicated that thallium-201 scintigraphy is useful for screening lung transplant recipients for episodes of acute rejection and/or infection. A positive scan is confirmation of graft parenchymal dysfunction and may then be followed by empirical treatment or bronchoscopy with transbronchial biopsy and culture to differentiate rejection and infection.

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“…Some authors suggested several factors that may be involved in the mechanism of gallium-67 citrate ( 67 Ga-citrate) localization in inflammatory tissues, including increased vascularity, protein accumulation ( 67 Ga-bound transferrin), and labeled leukocytes (Staab and McCartney 1978). The majority of gallium localization occurs because of leukocyte labeling and migration to the inflammatory site (Staab and McCartney 1978).…”

mentioning

confidence: 99%

“…The majority of gallium localization occurs because of leukocyte labeling and migration to the inflammatory site (Staab and McCartney 1978). A combination of several factors influences the accumulation of thallium-201 chloride ( 201 Tl) in brain tissue, including blood-brain barrier permeability, regional blood flow, cell proliferation, and Na-K ATPase activity, as 201 Tl behaves much like potassium (Kaplan et al 1987).…”

mentioning

confidence: 99%

Utility of Thallium-201 Scintigraphy in Tolosa-Hunt Syndrome

Kakisaka

Kobayashi

Uematsu

et al. 2013

Tohoku J. Exp. Med.

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Tolosa-Hunt syndrome (THS) is a rare disorder, especially in the pediatric population, characterized by unilateral painful ophthalmoplegia with a relapsing-remitting course. Because the diagnosis of THS is based on the exclusion of other causes of painful ophthalmoplegia, attention should be paid to possible alternative diagnoses. Thallium-201 chloride ( 201 Tl) scintigraphy has been used to evaluate tissue histology in clinical oncology with a marker, the retention index (RI). A higher value indicates histological malignancy. Although its utility in pediatric THS has not been discussed, we suggest that 201 Tl scintigraphy may be informative as a marker in the diagnosis. We present an 11-year-old boy with THS who was evaluated with 201 Tl scintigraphy before treatment with corticosteroids, when he had headache, photophobia, and diplopia. The RI of 201 Tl indicated that the lesion would be benign. Although his clinical symptoms did not fulfill the THS criteria completely, his eye symptoms disappeared 2 weeks after corticosteroid treatment, which was not within the 72 h as in the diagnostic criteria of THS. He has been symptom-free for more than 2 years with only an initial 4-week corticosteroid therapy. This report not only shows the potential of 201 Tl scintigraphy to contribute to the correct diagnosis of pediatric THS but also suggests the possibility that the diagnosis of THS could be supported uniquely even in a pediatric THS-suspicious patient who did not fulfill the current THS criteria completely. In conclusion, we suggest that 201 Tl scintigraphy may be useful for making the diagnosis of THS, especially in pediatric patients.

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Role of gallium 67 in inflammatory disease

Cited by 117 publications

References 25 publications

Diagnosis of bone, joint, and joint prosthesis infections with In-111-labeled nonspecific human immunoglobulin G scintigraphy.

Diagnosis of bone, joint, and joint prosthesis infections with In-111-labeled nonspecific human immunoglobulin G scintigraphy.

Thallium-201 scintigraphy in the evaluation of graft dysfunction in lung transplantation. Newark Beth Israel Medical Center Lung Transplant Group

Utility of Thallium-201 Scintigraphy in Tolosa-Hunt Syndrome

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