Role of fruits in aging and age-related disorders

Arif, Muhammad Usman; Khan, Muhammad Kashif Iqbal; Riaz, Sana; Nazir, Akmal; Maan, Abid Aslam; Amin, Usman; Saeed, Farhan; Afzaal, Muhammad

doi:10.1016/j.exger.2022.111763

Cited by 7 publications

(4 citation statements)

References 154 publications

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“…These positive effects are clearly associated with the well-known antioxidant and anti-inflammatory properties of grape phenolic compounds. These substances could exert a preventive effect associated with the age-related deterioration or sedentary lifestyle and the onset of damage associated with oxidative stress [51][52][53]. Therefore, future research should not only focus on improving underlying pathologies with antioxidant therapy, but also on prevention, through chronic supplementation with a polyphenol-rich ingredient.…”

Section: Discussionmentioning

confidence: 99%

Grape and Grape-Based Product Polyphenols: A Systematic Review of Health Properties, Bioavailability, and Gut Microbiota Interactions

et al. 2022

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Grapevine-derived products have been widely studied for their reported benefits, especially those related to the prevention of cardiovascular diseases. However, in recent years, the interest in the study of grapes and their non-fermented derivatives (grape juices) has gained prominence over the well-known interest in red wine, since grapes and grape juices seem to be widely related to the beneficial effects associated with the Mediterranean diet, and consequently to the presence of phenolic compounds. The focus of this systematic review was the phenolic profiles of grape, juice, and wine, as well as the possible beneficial effects of their consumption on the human microbiota through a systematic literature review. PubMed and Scopus were accessed during April 2021 and the PRISMA methodological protocol was followed. To the best of our knowledge, this is the first time that the PRISMA methodology has been applied to this systematic knowledge. This methodology allowed for a scientific description of: (a) the comparison between grapes and their derived products as source of phenolic compounds, (b) great possibilities for working on a new line of investigation based on the synergy between polyphenol consumption and microbiota, and (c) the urgent need for strategies to improve the bioavailability of these compounds.

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Section: Discussionmentioning

confidence: 99%

Grape and Grape-Based Product Polyphenols: A Systematic Review of Health Properties, Bioavailability, and Gut Microbiota Interactions

et al. 2022

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“…A critical dimension of aging is the profound impact of lifestyle choices, particularly dietary habits [5,20,[22][23][24][25][26], on the trajectory of aging and the risk of age-related diseases [27][28][29][30][31][32][33][34][35][36][37][38][39]. In this context, high-fat diets (HFDs) have emerged as a pervasive element of modern dietary patterns, characterized by their excessive consumption of saturated fats and relatively low nutritional value [40][41][42][43].…”

Section: Introductionmentioning

confidence: 99%

Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence

Balasubramanian,

Kiss,

Gulej

et al. 2024

Nutrients

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High-fat diets (HFDs) have pervaded modern dietary habits, characterized by their excessive saturated fat content and low nutritional value. Epidemiological studies have compellingly linked HFD consumption to obesity and the development of type 2 diabetes mellitus. Moreover, the synergistic interplay of HFD, obesity, and diabetes expedites the aging process and prematurely fosters age-related diseases. However, the underlying mechanisms driving these associations remain enigmatic. One of the most conspicuous hallmarks of aging is the accumulation of highly inflammatory senescent cells, with mounting evidence implicating increased cellular senescence in the pathogenesis of age-related diseases. Our hypothesis posits that HFD consumption amplifies senescence burden across multiple organs. To scrutinize this hypothesis, we subjected mice to a 6-month HFD regimen, assessing senescence biomarker expression in the liver, white adipose tissue, and the brain. Aging is intrinsically linked to impaired cellular stress resilience, driven by dysfunction in Nrf2-mediated cytoprotective pathways that safeguard cells against oxidative stress-induced senescence. To ascertain whether Nrf2-mediated pathways shield against senescence induction in response to HFD consumption, we explored senescence burden in a novel model of aging: Nrf2-deficient (Nrf2+/−) mice, emulating the aging phenotype. Our initial findings unveiled significant Nrf2 dysfunction in Nrf2+/− mice, mirroring aging-related alterations. HFD led to substantial obesity, hyperglycemia, and impaired insulin sensitivity in both Nrf2+/− and Nrf2+/+ mice. In control mice, HFD primarily heightened senescence burden in white adipose tissue, evidenced by increased Cdkn2a senescence biomarker expression. In Nrf2+/− mice, HFD elicited a significant surge in senescence burden across the liver, white adipose tissue, and the brain. We postulate that HFD-induced augmentation of senescence burden may be a pivotal contributor to accelerated organismal aging and the premature onset of age-related diseases.

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“…These aging‐related diseases accounted for 29.5 million deaths (72% of total death) among 54.7 million deaths in 2016 (Harris, 2019 ). Epidemiological studies show that a healthy diet containing fruits and vegetables correlates with a reduced progression of aging or various aging‐related disorders (Arif et al, 2022 ; Zhou et al, 2022 ). Though several medications are available for these diseases (Li et al, 2021 ), most of them manifest side effects upon implementation, and they might also become futile if the disease gets uncontrollable.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological potentials of lycopene against aging and aging‐related disorders: A review

Abir

Mahamud

Tonny

et al. 2023

Food Science & Nutrition

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Aging and aging‐related chronic disorders are one of the principal causes of death worldwide. The prevalence of these disorders is increasing gradually and globally. Considering this unwavering acceleration of the global burden, seeking alternatives to traditional medication to prevent the risk of aging disorders is needed. Among them, lycopene, a carotenoid, is abundant in many fruits and vegetables, including tomatoes, grapefruits, and watermelons, and it has a unique chemical structure to be a potent antioxidant compound. This nutraceutical also possesses several anti‐aging actions, including combating aging biomarkers and ameliorating several chronic disorders. However, no systematic evaluation has yet been carried out that can comprehensively elucidate the effectiveness of lycopene in halting the course of aging and the emergence of chronic diseases linked to aging. This review, therefore, incorporates previous pre‐clinical, clinical, and epidemiological studies on lycopene to understand its potency in treating aging disorders and its role as a mimic of caloric restriction. Lycopene‐rich foods are found to prevent or attenuate aging disorders in various research. Based on the evidence, this review suggests the clinical application of lycopene to improve human health and alleviate the prevalence of aging and aging disorders.

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Role of fruits in aging and age-related disorders

Cited by 7 publications

References 154 publications

Grape and Grape-Based Product Polyphenols: A Systematic Review of Health Properties, Bioavailability, and Gut Microbiota Interactions

Grape and Grape-Based Product Polyphenols: A Systematic Review of Health Properties, Bioavailability, and Gut Microbiota Interactions

Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence

Pharmacological potentials of lycopene against aging and aging‐related disorders: A review

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