Role of Faecalibacterium prausnitzii in Crohnʼs Disease

Gerasimidis, Konstantinos; Russell, Richard K.; Hansen, Richard; Quince, Christopher; Loman, Nicholas J.; Bertz, Martin; Hanske, Laura; Blaut, Michaël; McGrogan, Paraic; Edwards, Christine

doi:10.1097/mib.0000000000000079

Cited by 9 publications

(6 citation statements)

References 10 publications

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“…The fact that A. equolifaciens, originally isolated from human faeces, can produce equol by metabolizing daidzeins (Maruo et al, 2008) and utilizes hydrogen within its cell metabolism (Takagaki et al, 2014) suggests that this correlation may relate to the affinity of both A. equolifaciens and C. concisus for hydrogen. F. prausnitzii was previously shown to be an antiinflammatory commensal bacterium within the human gut (Sokol et al, 2008), although recent evidence paints a more complex role for this organism (Gerasimidis et al, 2014). It is unclear why ZOT levels correlate with the abundance of F. prausnitzii, but these results reaffirm the importance of taxa belonging to the phylum Firmicutes in potentially providing a suitable niche for Campylobacter spp.…”

Section: Jmm Correspondencesupporting

confidence: 73%

Faecal levels of zonula occludens toxin in paediatric patients with Crohn’s disease and their association with the intestinal microbiota

Kaakoush

Castaño-Rodríguez

Day

et al. 2015

Journal of Medical Microbiology

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Section: Jmm Correspondencesupporting

confidence: 73%

Faecal levels of zonula occludens toxin in paediatric patients with Crohn’s disease and their association with the intestinal microbiota

Kaakoush

Castaño-Rodríguez

Day

et al. 2015

Journal of Medical Microbiology

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“…The authors concluded that these results challenge the current perception of a protective role for F. prausnitzii. 56 Further publication by the Gerasimidis group confirmed that in pediatric CD, despite improvement in disease activity, EEN made the gut microbiome more dysbiotic, reducing gut microbiome diversity and decreasing the relative abundance of more than half of the bacterial taxonomic units during EEN (Table 2). [56][57][58][59] Schwerd et al, 58 in contrast, described an increase in the relative abundance of Firmicutes after EEN therapy.…”

Section: Modification Of Gut Microbiomementioning

confidence: 96%

“…56 Further publication by the Gerasimidis group confirmed that in pediatric CD, despite improvement in disease activity, EEN made the gut microbiome more dysbiotic, reducing gut microbiome diversity and decreasing the relative abundance of more than half of the bacterial taxonomic units during EEN (Table 2). [56][57][58][59] Schwerd et al, 58 in contrast, described an increase in the relative abundance of Firmicutes after EEN therapy. Guinet-Charpentier et al 59 recently demonstrated that patients who respond to EEN and in clinical remission showed a reduction in Dialister, Blautia, unclassified Ruminococcaceae and Coprococcus compared with patients in remission with other treatments, such as anti-TNF and PEN.…”

Section: Modification Of Gut Microbiomementioning

confidence: 96%

“…This change was associated with decrease in the gut mucosal inflammation and was sustained for 4 months after stopping EEN. 55 Gerasimidis et al 56 compared stool microbiome in 15 children with CD and 21 healthy subjects showing that the global bacterial diversity and F. prausnitzii concentration both significantly decreased during EEN; the greatest changes were seen in children who responded clinically to treatment with EEN. All these changes reverted to pre-treatment levels after the regular diet was recommenced.…”

Section: Modification Of Gut Microbiomementioning

confidence: 99%

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Dietary Treatment for Crohn’s Disease—Old Therapy, New Insights

Vora¹,

Puntis²

2017

Exploratory Research and Hypothesis in Medicine

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Crohn's disease in childhood accounts for about 25% of the overall prevalence of this condition, and compared with adult-onset disease has unique characteristics in being more likely to involve the colon, being more aggressive in behavior, and requiring early escalation of therapy. Exclusive enteral nutrition has proven to be an effective therapy, especially in children. There are various hypotheses regarding mode of action; however, the precise mechanisms are yet to be established. The aim of this paper is to provide an up-to-date review of the efficacy and mechanism of action of exclusive enteral nutrition in Crohn's disease. A PubMed search was performed using the terms 'mechanism of action', 'exclusive enteral nutrition', 'partial enteral nutrition', 'nutritional therapy', 'children', 'paediatric', 'Crohn's disease'. Relevant articles were selected from this search. In addition, the reference lists of these papers were scrutinized for further relevant publications. There is significant evidence for efficacy of exclusive enteral nutrition and some evidence for a number of mechanisms, including alteration of the gut microbiome, a direct anti-inflammatory effect at the mucosal level, and through alteration in the fat content within the diet. Exclusive enteral nutrition provides benefits beyond disease remission, especially through promoting growth; further studies are required to elucidate exactly how it works and the longer-term outcomes. This is particularly important given the lack of negative effects compared with the significant side-effect profile of biological therapies. Improving resources to minimize the psycho-social impact of exclusive enteral nutrition may open the way for wider use in adult patients through the development of solid diet alternatives to liquid feeds.

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“…Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium (13). Reduced microbial multiplicity illustrates dysbiosis in the gut microbiota, and those with PCD have lower levels of F. prausnitzii and higher levels of Escherichia coli (14). Butyrate, the end product of intestinal bacterial fermentation of primarily non-digestible carbohydrates such as resistant starch, is absorbed by the colon cells through transport pathways.…”

Section: Pediatric Crohn's Disease (Pcd)mentioning

confidence: 99%

Association of human gut microbiota with rare diseases: A close peep through

Roy

Nag

Saini

et al. 2022

IRDR

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disorders, human gut microbiome, personalized therapeutics, rare diseasesThe human body harbors approximately 10 14 cells belonging to a diverse group of microorganisms. Bacteria outnumbers protozoa, fungi and viruses inhabiting our gastrointestinal tract (GIT), commonly referred to as the "human gut microbiome". Dysbiosis occurs when the balanced relationship between the host and the gut microbiota is disrupted, altering the usual microbial population there. This increases the susceptibility of the host to pathogens, and chances of its morbidity. It is due to the fact that the gut microbiome plays an important role in human health; it influences the progression of conditions varying from colorectal cancer to GIT disorders linked with the nervous system, autoimmunity, metabolism and inheritance. A rare disease is a lethal and persistent condition affecting 2-3 people per 5,000 populaces. This review article intends to discuss such rare neurological, autoimmune, cardio-metabolic and genetic disorders of man, focusing on the fundamental mechanism that links them with their gut microbiome. Ten rare diseases, including Pediatric Crohn's disease (PCD), Lichen planus (LP), Hypophosphatasia (HPP), Discitis, Cogan's syndrome, Chancroid disease, Sennetsu fever, Acute cholecystitis (AC), Grave's disease (GD) and Tropical sprue (TS) stands to highlight as key examples, along with personalized therapeutics meant for them. This medicinal approach addresses the individual's genetic and genomic pathography, and tackles the illness with specific and effective treatments.

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Role of Faecalibacterium prausnitzii in Crohnʼs Disease

Cited by 9 publications

References 10 publications

Faecal levels of zonula occludens toxin in paediatric patients with Crohn’s disease and their association with the intestinal microbiota

Faecal levels of zonula occludens toxin in paediatric patients with Crohn’s disease and their association with the intestinal microbiota

Dietary Treatment for Crohn’s Disease—Old Therapy, New Insights

Association of human gut microbiota with rare diseases: A close peep through

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