Role of extracellular vesicles in chronic lung disease

Trappe, Anne; Donnelly, Seamas C.; McNally, Paul; Coppinger, Judith A.

doi:10.1136/thoraxjnl-2020-216370

Cited by 28 publications

(17 citation statements)

References 152 publications

(170 reference statements)

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“…Thymic stromal lymphopoietin (TSLP), thymus and activated chemokine (TARC), and IL-8 had also been used in the diagnosis of antifungal treatment of patients with asthma-induced ABPA ( Kozlova et al, 2020 ). In addition, extracellular vesicles (EVs), one kind of novel intercellular transporter, had also been confirmed in the role of diagnostic value in COPD, cystic fibrosis (CF), asthma, and lung cancer ( Trappe et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Microbiota Emergencies in the Diagnosis of Lung Diseases: A Meta-Analysis

Ruan

Deng²,

Dong³

et al. 2021

Front. Cell. Infect. Microbiol.

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Although many studies have reported that microbiota emergencies are deeply involved in the occurrence and subsequent progression of lung diseases, the present diagnosis of lung disease depends on microbiota markers, which is still poorly understood. Therefore, a meta-analysis was performed to confirm lung microbiota markers for the diagnosis of lung diseases. Literature databases were searched following the inclusion and exclusion criteria. There are 6 studies including 1347 patients and 26 comparisons to be enrolled, and then the diagnostic effect was evaluated using Stata 14.0 and Meta-disc 1.4 software. The pooled sensitivity (SEN), specificity (SPE), diagnostic likelihood ratio positive (DLR+), diagnostic likelihood ratio negative (DLR−), and diagnostic OR (DOR), as well as area under the curve (AUC) of microbiota markers in the diagnosis of lung diseases were 0.90 (95% CI: 0.83-0.94), 0.89 (95% CI: 0.76-0.95), 7.86 (95% CI: 3.39-18.21), 0.12 (95% CI: 0.06-0.21), 22.254 (95% CI: 12.83-39.59.14), and 0.95 (95% CI: 0.93-0.97), respectively. Subgroup analysis revealed that research based on Caucasian, adult, BAL fluid, PCR, pneumonia obtained higher AUC values. The microbiota markers have shown potential diagnosis value for lung diseases. But further large-scale clinical studies are still needed to verify and replicate the diagnostic value of lung microbiota markers.

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Section: Discussionmentioning

confidence: 99%

Microbiota Emergencies in the Diagnosis of Lung Diseases: A Meta-Analysis

Ruan

Deng²,

Dong³

et al. 2021

Front. Cell. Infect. Microbiol.

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“…As discussed above, cellular communication is of major importance in IPF, and part of this communication is mediated through EVs [ 201 , 202 ]. There is growing interest regarding the use of EVs isolated from anti-inflammatory and anti-fibrotic mesenchymal stem cells as a therapy for fibrotic disorders [ 203 , 204 ].…”

Section: Lipid-focused Therapiesmentioning

confidence: 99%

Extracellular Lipids in the Lung and Their Role in Pulmonary Fibrosis

Burgy

Loriod

Beltramo

et al. 2022

Cells

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Lipids are major actors and regulators of physiological processes within the lung. Initial research has described their critical role in tissue homeostasis and in orchestrating cellular communication to allow respiration. Over the past decades, a growing body of research has also emphasized how lipids and their metabolism may be altered, contributing to the development and progression of chronic lung diseases such as pulmonary fibrosis. In this review, we first describe the current working model of the mechanisms of lung fibrogenesis before introducing lipids and their cellular metabolism. We then summarize the evidence of altered lipid homeostasis during pulmonary fibrosis, focusing on their extracellular forms. Finally, we highlight how lipid targeting may open avenues to develop therapeutic options for patients with lung fibrosis.

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“…Clinically, EVs can be found and isolated from the majority of biological fluids, although blood and BALF are the most well-characterized sources of EVs ( 114 ). Increasing evidence has indicated that exosomes play a cardinal role in intercellular communication by delivering their shipments to target cells in the lungs (such as miRNAs).…”

Section: Role Of Exosomal Micrornas In Pulmonary Fibrosismentioning

confidence: 99%

Current and prospective applications of exosomal microRNAs in pulmonary fibrosis (Review)

et al. 2022

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Pulmonary fibrosis (PF) is a chronic, progressive, irreversible and life-threatening lung disease. However, the pathogenesis and molecular mechanisms of this condition remain unclear. Extracellular vesicles (EVs) are structures derived from the plasma membrane, with a diameter ranging from 30 nm to 5 µ m, that play an important role in cell-to-cell communications in lung disease, particularly between epithelial cells and the pulmonary microenvironment. In particular, exosomes are a type of EV that can deliver cargo molecules, including endogenous proteins, lipids and nucleic acids, such as microRNAs (miRNAs/miRs). These cargo molecules are encapsulated in lipid bilayers through target cell internalization, receptor-ligand interactions or lipid membrane fusion. miRNAs are single-stranded RNA molecules that regulate cell differentiation, proliferation and apoptosis by degrading target mRNAs or inhibiting translation to modulate gene expression. The aim of the present review was to discuss the current knowledge available on exosome biogenesis, composition and isolation methods. The role of miRNAs in the pathogenesis of PF was also reviewed. In addition, emerging diagnostic and therapeutic properties of exosomes and exosomal miRNAs in PF were described, in order to highlight the potential applications of exosomal miRNAs in PF.

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Role of extracellular vesicles in chronic lung disease

Cited by 28 publications

References 152 publications

Microbiota Emergencies in the Diagnosis of Lung Diseases: A Meta-Analysis

Microbiota Emergencies in the Diagnosis of Lung Diseases: A Meta-Analysis

Extracellular Lipids in the Lung and Their Role in Pulmonary Fibrosis

Current and prospective applications of exosomal microRNAs in pulmonary fibrosis (Review)

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