Role of extracellular LncRNA-SNHG14/miRNA-3940-5p/NAP12 mRNA in colorectal cancer

Matboli, Marwa; Shafei, Ayman; Ali, Mahmoud; Ahmed, Tarek Salah El-Din; Naser, Mahmoud; Abdelrahman, Tamer Nabil; Anber, Nahla Hamed; Ali, Marwa

doi:10.1080/13813455.2019.1650070

Cited by 14 publications

(13 citation statements)

References 31 publications

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“…**p < 0.01. SNHG14 sponged miR-206-3p thus leading to gefitinib resistance (Wu et al 2019); in colorectal cancer, SNHG14 sponged miR-32-5p, miR-3940-5p and miR-92b-3p, thus promoting cell proliferation, migration and invasion (Matboli et al 2019;Ye et al 2019;Zhang et al 2020). In current study, SNHG14 was found to be increased in NCSLC tissues and cell line, and SNHG14 siRNA was discovered to inhibit proliferation and invasion, while promote apoptosis in NSCLC cell line.…”

Section: Discussionmentioning

confidence: 52%

LncRNA SNHG14 promotes non-small cell lung cancer progression by sponging miR-382-5p

Zhou

Fang

et al. 2020

All Life

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Long non-coding RNAs (lncRNAs) are involved in development of non-small cell lung cancer (NSCLC) by interacting with microRNAs (miRNAs) and/or mRNAs. However, the function of most lncRNAs in NSCLC remains unclear. Reverse transcription-quantitative PCR (RT-qPCR) and western blot were applied for detection of mRNA/miRNA and protein level. Interaction between LncRNA small nucleolar RNA host gene 14 (SNHG14) and miR-382-5p was validated by dual luciferase reporter assay. Cell proliferation and apoptosis was detected using Cell Counting Kit 8 (CCK8) and Flow cytometry, while cell migration and invasion was detected by scratch assay and Transwell assay. SNHG14 was upregulated in NSCLC tissues and cell lines. SNHG14 silencing reduced proliferation, migration and invasion, and induced apoptosis in A549 cells. SNHG14 was negatively correlated with miR-382-5p in NSCLC tissues, SNHG14 and miR-382-5p negatively regulated each other in A549 cells. SNHG14 promoted expression of miR-382-5p target genes, including LIM-only protein 3 (LMO3) and SET domain containing lysine methyltransferase 8 (SETD8), in A549 cells. miR-382-5p inhibition reversed SNHG14 knockdown-induced increase in apoptosis and decrease in proliferation, migration and invasion. SNHG14 was correlated with SETD8 and LMO3 in NSCLC tissues. Collectively, SNHG14 promoted NSCLC proliferation, migration and invasion, while inhibited apoptosis by sponging miR-382-5p in A549 cells.

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Section: Discussionmentioning

confidence: 52%

LncRNA SNHG14 promotes non-small cell lung cancer progression by sponging miR-382-5p

Zhou

Fang

et al. 2020

All Life

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“…These contradictory results are probably caused by that they set different normal cell lines as control groups. For instance, the expression of SNHG14 in FHC cell lines is higher than other cancer cells but is lower in NCM460 cell lines (28,(30)(31)(32)(33). Thus, the function of SNHG14 is complicated and might serve as both positive and negative roles in cancer initiation and progression corresponding to bio-context.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Based System Biology Exploration Reveals Homogeneous Tumorigenicity of Alimentary Tract Malignancy

Shi

Zhang

et al. 2021

Front. Oncol.

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Malignancies of alimentary tract include esophageal carcinoma (ESCA), stomach adenocarcinoma (STAD), colon adenocarcinoma (COAD), and rectum adenocarcinoma (READ). Despite of their similarities in cancer development and progression, there are numerous researches concentrating on single tumor but relatively little on their common mechanisms. Our study explored the transcriptomic data of digestive tract cancers from The Cancer Genome Atlas database, yielding their common differentially expressed genes including 1,700 mRNAs, 29 miRNAs, and 362 long non-coding RNAs (lncRNAs). There were 12 mRNAs, 5 miRNAs, and 16 lncRNAs in the core competitive endogenous RNAs network by RNA-RNA interactions, highlighting the prognostic nodes of SERPINE1, hsa-mir-145, and SNHG1. In addition, the weighted gene co-expression network analysis (WGCNA) illustrated 20 gene modules associated with clinical traits. By taking intersections of modules related to the same trait, we got 67 common genes shared by ESCA and READ and screened 5 hub genes, including ADCY6, CXCL3, NPBWR1, TAS2R38, and PTGDR2. In conclusion, the present study found that SERPINE1/has-mir-145/SNHG1 axis acted as promising targets and the hub genes reasoned the similarity between ESCA and READ, which revealed the homogeneous tumorigenicity of digestive tract cancers at the transcriptome level and led to further comprehension and therapeutics for digestive tract cancers.

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“…Previous studies have demonstrated the vital regulatory functions of lncRNA-miRNA network in types of human cancers, such as diabetic pancreatic cancer and colorectal cancer (33,34). In the field of GC, lncRNA gastric cancer-related lncRNA1 has been reported to modulate GC cell proliferation and metastasis by sponging miR-885-3p (35).…”

Section: Discussionmentioning

confidence: 99%

lncRNA LIFR‑AS1 inhibits gastric carcinoma cell proliferation, migration and invasion by sponging miR‑4698

Zhao

et al. 2020

Mol Med Rep

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Role of extracellular LncRNA-SNHG14/miRNA-3940-5p/NAP12 mRNA in colorectal cancer

Cited by 14 publications

References 31 publications

LncRNA SNHG14 promotes non-small cell lung cancer progression by sponging miR-382-5p

LncRNA SNHG14 promotes non-small cell lung cancer progression by sponging miR-382-5p

Transcriptome Based System Biology Exploration Reveals Homogeneous Tumorigenicity of Alimentary Tract Malignancy

lncRNA LIFR‑AS1 inhibits gastric carcinoma cell proliferation, migration and invasion by sponging miR‑4698

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