Role of estrogen and progesterone in the regulation of uterine peristalsis: results from perfused non-pregnant swine uteri

Mueller, Andreas; Siemer, J.; Schreiner, SJ; Koesztner, H.; Hoffmann, Inge; Binder, Helge; Beckmann, Matthias W.; Dittrich, Ralf

doi:10.1093/humrep/del056

Cited by 46 publications

(41 citation statements)

References 45 publications

(48 reference statements)

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“…The vitality parameters remained physiologic during the first 8 h of perfusion (data not shown [35][36][37][38][39][40]). Regularly recurring peristaltic waves, with IUP increases in both the corpus uteri and the isthmus uteri, were achieved in all of the perfused swine uteri and were continuously measured using the intrauterine double-chip catheter (39).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Differences in muscarinic-receptor agonist–, oxytocin-, and prostaglandin-induced uterine contractions

Dittrich

Mueller

Oppelt

et al. 2009

Fertility and Sterility

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Section: Resultsmentioning

confidence: 99%

“…This perfusion model is able to keep the uterus in a functional condition and is suitable for the study of physiologic questions (32)(33)(34). The development of an extracorporeal perfusion model of the swine uterus enabled our group to carry out general assessments of uterine contractility and peristalsis (35)(36)(37)(38)(39)(40).…”

mentioning

confidence: 99%

Differences in muscarinic-receptor agonist–, oxytocin-, and prostaglandin-induced uterine contractions

Dittrich

Mueller

Oppelt

et al. 2009

Fertility and Sterility

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“…We have previously described the swine uterus perfusion model in more detail and validated it for different physiological questions [26][27][28][29][30][31][32][33][34]. Briefly, the perfusion medium was oxygenated with carbogen gas (a mixture of 95% oxygen and 5% carbon dioxide) and then forced into uterine arterial catheters with two roller pumps.…”

Section: Perfusion Systemmentioning

confidence: 99%

“…According to previously reported in vitro experiments, there is a possible clinical relationship between uterine contractility and steroid hormones [24,25]. We have previously described a sw ine-uterus perfusion model that is also suitable for the study of physiological questions [26][27][28][29][30][31][32][33][34]. Continuous monitoring of intrauterine pressure using multiple probes at different locations inside the uterus may be a suitable method of evaluating directed transport mechanisms through the female genital tract, believing that these transport mechanisms may be caused by uterine contractility, peristaltic waves, and directed pressure gradients.…”

mentioning

confidence: 99%

Perfused Non-Pregnant Swine Uteri: A Model for Evaluating Transport Mechanisms to the Side Bearing the Dominant Follicle in Humans

Mueller

Siemer

Renner

et al. 2006

Journal of Reproduction and Development

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Abstract. Adequate uterine contractility and periovulatory peristalsis, interpreted as "rapid sperm transport" to the side bearing the dominant follicle, may be a precondition for successful reproduction in humans. Estrogen and progesterone fluctuate characteristically during the menstrual cycle, and their source is the dominant follicle and corpus luteum. The question is, how is the direction to the left or right side of transport mechanisms influenced? An extracorporeal perfusion model of the swine uterus was used that maintained the uterus in a functional condition and that was suitable for the study of physiological questions. The effects of side-dependent estrogen, progesterone, and estrogen plus progesterone perfusion on oxytocin-induced uterine peristalsis were assessed using two intrauterine microcatheters placed in each horn of the swine uterus. Estrogen perfusion was associated with an increase in intrauterine pressure (IUP) in a dose-dependent manner only in the estrogen-perfused horn of the swine uterus. There was a significant difference between the IUP increase measured in the estrogen-perfused horn and that in the non estrogen-perfused horn of the swine uterus. Progesterone perfusion showed no effect in general. Furthermore, progesterone antagonized the estrogen effects. This study demonstrates that side-dependent estrogen perfusion resulted in side-dependent contractility in the swine uterus perfusion system used. These observations show that estrogen stimulates uterine contractility in the estrogen-perfused uterine horn and that estrogens may be the "trigger" for the transport mechanisms to the side bearing the dominant follicle during the periovulatory phase through their locally increased concentration and distribution via the utero-ovarian counter-current system in humans.

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“…Although there is evidence indicating the contribution of conractile activity of the nonpregnant uterus to reproduction process (Franchin et al 2002;Mueller et al 2006a), there are no data available on the effect of smoking or nicotine itself on the uterus contraction. Therefore, this study was designed to investigate the effect of nicotine, the principal chemical in tobacco, on electrical field stimulation (EFS)-evoked contractile responses in rabbit myometrium to clarify whether nicotine leads to a change in the contractility.…”

mentioning

confidence: 99%

Nicotine Potentiates the Electrical Field Stimulation-Evoked Contraction of Non-Pregnant Rabbit Myometrium

Nas

Barun

Öztürk

et al. 2007

Tohoku J. Exp. Med.

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The women who smoke have lower fertility rates which might be due to harmful effects of nicotine on tubal function and menstrual cycle. Although the uterine contractility of the non-pregnant uterus plays an important role in the human reproduction process, the influence of nicotine on the contractile responses in uterus is not known. Nicotine increases the release of neurotransmitters following nerve stimulation both in the central and peripheral nervous system through acting on nicotinic acetylcholine receptors (nAchRs). The aim of this study was to examine whether the electrical field stimulation (EFS)-evoked contraction is altered in rabbit myometrium strips in the presence of nicotine to evaluate the changes in contractility. EFS-evoked contractile responses were recorded from myometrium strips obtained from non-pregnant rabbits in the absence and presence of nicotine. Nicotine led to the increase in the amplitudes of the EFS-evoked contractile responses in a dose-dependent manner. Therefore, the effects of hexamethonium, cadmium, indomethacin, atropine, and N ω -Nitro-L-arginine methyl ester hydrochloride were tested on the EFS-evoked contractions in the absence or presence of nicotine to clarify the mechanisms of nicotine-induced potentiation in EFS-evoked contractile responses. Indomethacin, a non-selective cyclooxygenase inhibitor, and hexamethonium, a ganglionic blocker, inhibited nicotine-induced increase in EFS-evoked responses, whereas other chemicals produced no effect. These results suggest that nicotine-induced potentiation may be mediated by nAchRs and prostaglandins. In conclusion, failure of quiescence in the uterus due to increased contractility by nicotine might be one of the factors contributing to infertility in female smokers.nicotine; rabbit; myometrium; electrical field stimulation

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Role of estrogen and progesterone in the regulation of uterine peristalsis: results from perfused non-pregnant swine uteri

Cited by 46 publications

References 45 publications

Differences in muscarinic-receptor agonist–, oxytocin-, and prostaglandin-induced uterine contractions

Differences in muscarinic-receptor agonist–, oxytocin-, and prostaglandin-induced uterine contractions

Perfused Non-Pregnant Swine Uteri: A Model for Evaluating Transport Mechanisms to the Side Bearing the Dominant Follicle in Humans

Nicotine Potentiates the Electrical Field Stimulation-Evoked Contraction of Non-Pregnant Rabbit Myometrium

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