Role of Erythrocyte Sedimentation Rate (ESR) in preparation of Platelet and Extracellular Vesicles Rich Plasma

Abstract

Uses of platelet and extracellular vesicles rich plasma (PVRP) are in many fields of medicine as it was found that PVRP has regenareative properties. Preparation of PVRP is performed by sep-aration of erythrocytes from the liquid they are immersed in. Erythrocytes are the most numerous blood cells; they are also relatively large and dense as they are filled with haemoglobin. Therefore they sediment due to gravitation or systemic centrifugation force thereby pushing plasma that carries smaller particles in the opposite direction. This mechanism that takes place during pro-cessing determines the composition of plasma. Its tuning is therefore key in acquiring a prepara-tion with desired properties. In particular, it is of interest to study the effect of erythrocyte sedi-mentation rate (ESR) on composition and volume of acquired plasma. Different animals have different ranges of ESR values which may enable insight into mechanisms of plasma preparation. In this contribution we present the basic mechanisms of plasma preparation and properties of blood of different animals.