Role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease

Lenk, Karsten; Uhlemann, Madlen; Schuler, Gerhard; Adams, Volker

doi:10.1152/japplphysiol.01464.2010

Cited by 41 publications

(31 citation statements)

References 104 publications

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“…The mechanism for how EPCs improve endothelial function or elicit new vessel development (i.e. vasculogenesis) is not completely understood, but putative mechanisms have been reviewed 73 .…”

Section: Et Improves Epicardial (Conduit) Vessel Vasoreactivitymentioning

confidence: 99%

Benefits of Exercise Training on Coronary Blood Flow in Coronary Artery Disease Patients

Bruning

Sturek

2015

Progress in Cardiovascular Diseases

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Every 34 seconds an American experiences a myocardial infarction or cardiac death. Approximately 80% of these coronary artery disease (CAD)-related deaths are attributable to modifiable behaviors, such as a lack of physical exercise training (ET). Regular ET decreases CAD morbidity and mortality through systemic and cardiac-specific adaptations. ET increases myocardial oxygen demand acting as a stimulus to increase coronary blood flow and thus myocardial oxygen supply, which reduces myocardial infarction and angina. ET augments coronary blood flow through direct actions on the vasculature that improve endothelial and coronary smooth muscle function, enhancing coronary vasodilation. Additionally, ET promotes collateralization, thereby, increasing blood flow to ischemic myocardium and also treats macrovascular CAD by attenuating the progression of coronary atherosclerosis and restenosis, potentially through stabilization of atherosclerotic lesions. In summary, ET can be used as a relatively safe and inexpensive way to prevent and treat CAD.

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Section: Et Improves Epicardial (Conduit) Vessel Vasoreactivitymentioning

confidence: 99%

Benefits of Exercise Training on Coronary Blood Flow in Coronary Artery Disease Patients

Bruning

Sturek

2015

Progress in Cardiovascular Diseases

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“…A decrease in the number of EPCs could increase coronary artery disease incidence and coronary artery disease related-mortality [4]. Aging, diabetes mellitus, hypertension, hypercholesterolemia, and chronic kidney disease can have a significant negative effect on the number and function of EPCs [5,6,7,8]. A recent study has reported that the number of EPCs and the capacity to form EPC colonies affect health, since EPCs cluster around ischemic damaged tissues to repair the damage.…”

Section: Introductionmentioning

confidence: 99%

Regular Exercise Training Increases the Number of Endothelial Progenitor Cells and Decreases Homocysteine Levels in Healthy Peripheral Blood

Choi

Moon

Jung

et al. 2014

Korean J Physiol Pharmacol

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Endothelial progenitor cells (EPCs) are known to play an important role in the repair of damaged blood vessels. We used an endothelial progenitor cell colony-forming assay (EPC-CFA) to determine whether EPC numbers could be increased in healthy individuals through regular exercise training. The number of functional EPCs obtained from human peripheral blood-derived AC133 stem cells was measured after a 28-day regular exercise training program. The number of total endothelial progenitor cell colony-forming units (EPC-CFU) was significantly increased compared to that in the control group (p=0.02, n=5). In addition, we observed a significant decrease in homocysteine levels followed by an increase in the number of EPC-CFUs (p=0.04, n=5), indicating that the 28-day regular exercise training could increase the number of EPC colonies and decrease homocysteine levels. Moreover, an inverse correlation was observed between small-endothelial progenitor cell colony-forming units (small-EPC-CFUs) and plasma homocysteine levels in healthy men (r=-0.8125, p=0.047). We found that regular exercise training could increase the number of EPC-CFUs and decrease homocysteine levels, thus decreasing the cardiovascular disease risk in men.

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“…In addition, physical activity mitigates vascular inflammation while it improves anti-oxidant defences, also contributing for improving endothelial dysfunction[64-66]. Physical activity also promotes the mobilization of endothelial progenitor cells into the circulation to maintain endothelial integrity and stimulate vascular regeneration and endothelial repair[67,68]. …”

Section: Cardiovascular Protection Mechanisms Induced By Physical Actmentioning

confidence: 99%

Physical activity in primary and secondary prevention of cardiovascular disease: Overview updated

Alves¹,

Viana²,

Cavalcante³

et al. 2016

WJC

141

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Although the observed progress in the cardiovascular disease treatment, the incidence of new and recurrent coronary artery disease remains elevated and constitutes the leading cause of death in the developed countries. Three-quarters of deaths due to cardiovascular diseases could be prevented with adequate changes in lifestyle, including increased daily physical activity. New evidence confirms that there is an inverse dose-response relationship between physical activity and cardiovascular disease and mortality risk. However, participation in moderate to vigorous physical activity may not fully attenuate the independent effect of sedentary activities on increased risk for cardiovascular diseases. Physical activity also plays an important role in secondary prevention of cardiovascular diseases by reducing the impact of the disease, slowing its progress and preventing recurrence. Nonetheless, most of eligible cardiovascular patients still do not benefit from secondary prevention/cardiac rehabilitation programs. The present review draws attention to the importance of physical activity in the primary and secondary prevention of cardiovascular diseases. It also addresses the mechanisms by which physical activity and regular exercise can improve cardiovascular health and reduce the burden of the disease.

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Role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease

Abstract: Lenk K, Uhlemann M, Schuler G, Adams V. Role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease.

Cited by 41 publications

References 104 publications

Benefits of Exercise Training on Coronary Blood Flow in Coronary Artery Disease Patients

Benefits of Exercise Training on Coronary Blood Flow in Coronary Artery Disease Patients

Regular Exercise Training Increases the Number of Endothelial Progenitor Cells and Decreases Homocysteine Levels in Healthy Peripheral Blood

Physical activity in primary and secondary prevention of cardiovascular disease: Overview updated

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