Role of dynamic MRI in differentiating benign from malignant follicular thyroid nodule

Gupta, Nikhil; Norbu, Choden; Goswami, Binita; Chowdhury, Veena; Ravishankar, L.; Gulati, Praveen; Kakar, Atul

doi:10.1016/j.anl.2011.02.002

Cited by 8 publications

(6 citation statements)

References 24 publications

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“…Follicular thyroid carcinoma showed marked enhancement because of abundant hyperplasia of thyroid follicles and neovascularity. Papillary thyroid carcinomas demonstrated moderate or marked enhancement with increased cell density, severe desmoplastic response, and cell proliferation, which were consistent with previous studies [ 26 , 29 ].…”

Section: Discussionsupporting

confidence: 92%

Diagnostic efficacy of multiple MRI parameters in differentiating benign vs. malignant thyroid nodules

et al. 2018

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BackgroundDiffusion weighted imaging (DWI) has a good diagnostic value for malignant thyroid nodules, but the published protocols suffer from flaws and focus on the apparent diffusion coefficient (ADC). This study investigated the diagnostic performance of multiple MRI parameters in differentiating malignant from benign thyroid nodules.MethodsThis was a retrospective study of 181 consecutive patients (148 benign and 111 malignant nodules, confirmed by pathological results). The patients underwent conventional MRI, DWI, and dynamic contrast-enhanced MRI before surgery. The chi-square test and the Student t test were used to compare the conventional features and ADC value between malignant and benign groups. Multivariate logistic regression was used to identify the independent predictors and to construct a model. Receiver operator characteristic (ROC) curve analysis was used to assess the diagnostic performance of the independent variables and model.ResultsTumor diameter, ADC value, cystic degeneration, pseudocapsule sign, high signal cystic area on T1-weighted imaging, ring sign in the delayed phase, and irregular shape showed significant differences between two groups (all P < 0.05). The multivariable analysis revealed that ADC value (OR = 694.006, P < 0.001), irregular shape (OR = 32.798, P < 0.001), ring sign in the delayed phase (OR = 20.381, P = 0.004), and cystic degeneration (OR = 8.468, P = 0.016) were independent predictors. Among them, ADC performed the best in discriminating benign from malignant nodules, with an area under the curve (AUC) of 0.95, 0.90 sensitivity, and 0.91 specificity. When the independent factors were combined, the diagnostic performance was improved with an AUC of 0.99, 0.97 sensitivity, and 0.95 specificity.ConclusionsADC value could discriminate between benign and malignant thyroid nodules with a good performance. Subjective features such as the ring sign, irregular shape, and cystic degeneration associated with malignant thyroid nodules could provide complementary information for differentiation.

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Section: Discussionsupporting

confidence: 92%

Diagnostic efficacy of multiple MRI parameters in differentiating benign vs. malignant thyroid nodules

et al. 2018

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“…The majority of the recent DCE‐TIC studies of thyroid nodules showed that most malignant thyroid carcinomas displayed a plateau pattern, while most benign lesions showed a rapid washout pattern . However, Gupta et al's results came to contradictory conclusions using different parameters including dynamic phases, injection rates, contrast dosages, and scan sequence . Based on these contradictory conclusions, reasonable parameters in thyroid DCE‐TIC studies still need to be defined.…”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10] However, Gupta et al's results came to contradictory conclusions using different parameters including dynamic phases, injection rates, contrast dosages, and scan sequence. 11 Based on these contradictory conclusions, reasonable parameters in thyroid DCE-TIC studies still need to be defined.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, magnetic resonance imaging (MRI) studies of thyroid nodules have addressed the differentiation between thyroid cancers, especially PTCs, from benign nodules. Current clinical thyroid MRI studies concentrate on the appearance of nodules in a T 1 ‐weighted ( T 1 W) and T 2 ‐weighted ( T 2 W) turbo‐spin echo (TSE) sequence, the diffusion weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping, and dynamic contrast enhancement (DCE) using gadolinium with a time–intensity curve (TIC) …”

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confidence: 99%

“…Current clinical thyroid MRI studies concentrate on the appearance of nodules in a T 1 -weighted (T 1 W) and T 2 -weighted (T 2 W) turbo-spin echo (TSE) sequence, the diffusion weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping, 6,7 and dynamic contrast enhancement (DCE) using gadolinium with a time-intensity curve (TIC). [8][9][10][11] T 2 *-weighted imaging has been use to assess iron overload of the myocardium 12 and the kidneys in thalassemic patients. 13 Mamisch et al used the T 2 * relaxation time to evaluate articular cartilage.…”

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confidence: 99%

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T₂* mapping at 3.0T MRI for differentiation of papillary thyroid carcinoma from benign thyroid nodules

Shi

Yao

et al. 2015

J. Magn. Reson. Imaging

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The Use of Dynamic Contrast-Enhanced Perfusion MRI in Differentiating Benign and Malignant Thyroid Nodules

Sakat

Sade

Kılıç

et al. 2018

Indian J Otolaryngol Head Neck Surg

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Role of dynamic MRI in differentiating benign from malignant follicular thyroid nodule

Cited by 8 publications

References 24 publications

Diagnostic efficacy of multiple MRI parameters in differentiating benign vs. malignant thyroid nodules

Diagnostic efficacy of multiple MRI parameters in differentiating benign vs. malignant thyroid nodules

T₂* mapping at 3.0T MRI for differentiation of papillary thyroid carcinoma from benign thyroid nodules

The Use of Dynamic Contrast-Enhanced Perfusion MRI in Differentiating Benign and Malignant Thyroid Nodules

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Role of dynamic MRI in differentiating benign from malignant follicular thyroid nodule

Cited by 8 publications

References 24 publications

Diagnostic efficacy of multiple MRI parameters in differentiating benign vs. malignant thyroid nodules

Diagnostic efficacy of multiple MRI parameters in differentiating benign vs. malignant thyroid nodules

T2* mapping at 3.0T MRI for differentiation of papillary thyroid carcinoma from benign thyroid nodules

The Use of Dynamic Contrast-Enhanced Perfusion MRI in Differentiating Benign and Malignant Thyroid Nodules

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T₂* mapping at 3.0T MRI for differentiation of papillary thyroid carcinoma from benign thyroid nodules