Role of dorsal hippocampal orexin-1 receptors in modulation of antinociception induced by chemical stimulation of the lateral hypothalamus

Pourreza, Pooya; Babapour, Vahab; Haghparast, Abbas

doi:10.1016/j.physbeh.2017.12.036

Cited by 21 publications

(13 citation statements)

References 47 publications

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“…Orexin signaling in some spinal and supra-spinal sites regulates descending pain modulatory circuitry. The involvement of the orexinergic system in pain modulation suggests that orexins may be potential therapeutic targets for chronic pain treatment [117].…”

Section: The Role Of Neurotransmitters In Chronic Painmentioning

confidence: 99%

Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Negative Affective States

Yang

Lee

2019

IJMS

227

158

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Chronic pain is a condition in which pain progresses from an acute to chronic state and persists beyond the healing process. Chronic pain impairs function and decreases patients’ quality of life. In recent years, efforts have been made to deepen our understanding of chronic pain and to develop better treatments to alleviate chronic pain. In this review, we summarize the results of previous studies, focusing on the mechanisms underlying chronic pain development and the identification of neural areas related to chronic pain. We review the association between chronic pain and negative affective states. Further, we describe the structural and functional changes in brain structures that accompany the chronification of pain and discuss various neurotransmitter families involved. Our review aims to provide guidance for the development of future therapeutic approaches that could be used in the management of chronic pain.

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Section: The Role Of Neurotransmitters In Chronic Painmentioning

confidence: 99%

Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Negative Affective States

Yang

Lee

2019

IJMS

227

158

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“…On the other hand, evidence suggests that the hippocampus modulates pain through orexin (47). Furthermore, the hippocampus is involved in opioid and non-opioid SIA (48, 49).…”

Section: Discussionmentioning

confidence: 99%

Contribution of the intra-hippocampal orexin system in the regulation of restraint stress response to pain-related behaviors in the formalin test

Sadeghi

Zareie

Gholami

et al. 2023

Preprint

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Stress-induced analgesia (SIA) is due to the activation of several neural pathways and neurotransmitters that often suppress pain perception. Studies have shown that the orexin neuropeptide system is essential in pain modulation. Therefore, this study aims to investigate the role of orexinergic receptors in the hippocampal CA1 region in modulating the SIA response during the formalin test as an animal model of inflammatory pain. Orexin-1 receptor (OX1r) antagonist, SB334867, at 1, 3, 10, and 30 nmol or TCS OX2 29 as orexin-2 receptor (OX2r) antagonist at the same doses were microinjected into the CA1 region in rats. Five minutes later, rats were exposed to restraint stress (RS) for 3 hours, and pain-related behaviors were monitored in 5-min blocks for the 60-min test period in the formalin test. Results showed that applying RS for 3 hours reduced pain responses in the early and late phases of the formalin test. The main findings showed that intra-CA1 injection of orexin receptor antagonists reduced the analgesia caused by stress in both phases of the formalin test. In addition, the contribution of OX1r in mediating the analgesic effect of stress was more prominent than that of OX2r in the early phase of the formalin test. However, in the late phase, both receptors worked similarly. Accordingly, the orexin system and its two receptors in the CA1 region of the hippocampus regulate the SIA response to this animal model of chronic pain.

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“…It has been documented that intra-CA1 administration of MK-801 as an antagonist of the N-methyl-D-aspartate receptor reduced nociceptive response during the late phase of the formalin test (Soleimannejad et al , 2007). Besides, the previous study has shown that the drug stimulation of the lateral hypothalamus induces antinociceptive response directly through activation of orexin receptors of the CA1 region (Pourreza et al , 2018) and indirectly via activation of dopamine receptors in the CA1 (Rezaee et al , 2020; Zakeri et al , 2020). Both endogenous and exogenous acetylcholine in the hippocampal CA1 area are also involved in the nociceptive processing (Yang et al , 2008).…”

Section: Discussionmentioning

confidence: 99%

The modulatory role of dopamine receptors within the hippocampal cornu ammonis area 1 in stress-induced analgesia in an animal model of persistent inflammatory pain

Dezfouli

Merdasi

Rashvand

et al. 2022

Behavioural Pharmacology

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The intrinsic pain inhibitory mechanisms can be activated by fear, anxiety, and stress. Stressful experiences produce analgesia, referred to as stress-induced analgesia (SIA). Major components of the limbic system, including the ventral tegmental area, nucleus accumbens, amygdala, and hippocampus, are involved in the SIA. In this study, we tried to understand the role of dopamine receptors in the cornu ammonis area 1 (CA1) of the hippocampus in the forced swim stress (FSS)-induced analgesia. Stereotaxic surgery was unilaterally performed on 129 adult male Wistar rats weighing 220–280 g. SCH23390 (0.25, 1, and 4 μg/0.5 μl saline) or sulpiride (0.25, 1, and 4 μg/0.5 μl DMSO), as D1- and D2-like dopamine receptor antagonists, respectively, were microinjected into the CA1 area, 5 min before exposure to FSS for a 6-min period. The vehicle groups received saline or DMSO instead of SCH23390 or sulpiride, respectively. The formalin test was done using formalin injection (50 μl; 2.5%) into the plantar surface of the rat’s hind paw immediately after exposure to FSS. The results demonstrated that FSS produces analgesia during the early and late phases of the formalin test. However, intra-CA1 microinjection of SCH23390 or sulpiride attenuated the FSS-induced analgesia in both phases of the formalin test. This study provides new insight into the role of D1- and D2-like dopamine receptors in the CA1 area in the FSS-induced analgesia during persistent inflammatory pain.

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Role of dorsal hippocampal orexin-1 receptors in modulation of antinociception induced by chemical stimulation of the lateral hypothalamus

Cited by 21 publications

References 47 publications

Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Negative Affective States

Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Negative Affective States

Contribution of the intra-hippocampal orexin system in the regulation of restraint stress response to pain-related behaviors in the formalin test

The modulatory role of dopamine receptors within the hippocampal cornu ammonis area 1 in stress-induced analgesia in an animal model of persistent inflammatory pain

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