Role of dopamine receptors in the ventral tegmental area in conditioned fear

Oliveira, Amanda Ribeiro de; Reimer, Adriano E.; Brandão, Marcus Lira

doi:10.1016/j.bbr.2008.12.004

Cited by 56 publications

(42 citation statements)

References 48 publications

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“…Long-term APD use resulting in the up-regulation and hypersensitivity of DA receptors and thus enhanced dopaminergic signalling may also play a role, with enhanced DA signalling in brain regions including the ventral tegmental area, prefrontal cortex and nucleus accumbens correlated with the anxiolytic-and decreased depressive-like behavioural effects exhibited in the present study (Karl et al 2006;de Oliveira et al 2009;Biojone et al 2011).…”

Section: Discussionmentioning

confidence: 52%

“…In such cases, a deficiency in 5-HT projections leads to a disinhibition of DA signalling, and thus enhanced DA signal (Kusljic et al 2003;Seo et al 2008). Similarly, the antagonistic actions of Olanzapine and Risperidone on the 5-HT 2A , 5-HT 2C and DA D 2 receptors, resulting in the aforementioned long-term alterations in signalling, have also been correlated to anxiolytic and decreased depressive-like behaviours (Mora et al 1997;Andersen and Navalta 2004;Karl et al 2006;Dunlop and Nemeroff 2007;Seo et al 2008;de Oliveira et al 2009;Biojone et al 2011). Previous studies have demonstrated that repeated antagonism of the 5-HT 2 receptors (both 5-HT 2A and 5-HT 2C )…”

Section: Discussionmentioning

confidence: 99%

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Early antipsychotic treatment in childhood/adolescent period has long-term effects on depressive-like, anxiety-like and locomotor behaviours in adult rats

et al. 2015

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. (2016). Early antipsychotic treatment in childhood/adolescent period has long-term effects on depressive-like, anxiety-like and locomotor behaviours in adult rats. Journal of Psychopharmacology, 30 (2),[204][205][206][207][208][209][210][211][212][213][214] Early antipsychotic treatment in childhood/adolescent period has longterm effects on depressive-like, anxiety-like and locomotor behaviours in adult rats AbstractChildhood/adolescent antipsychotic drug (APD) use is exponentially increasing worldwide, despite limited knowledge of the long-term effects of early APD treatment. Whilst investigations have found that early treatment has resulted in some alterations to dopamine and serotonin neurotransmission systems (essential to APD efficacy), there have only been limited studies into potential long-term behavioural changes. This study, using an animal model for childhood/adolescent APD treatment, investigated the long-term effects of aripiprazole, olanzapine and risperidone on adult behaviours of male and female rats. Open-field/holeboard, elevated plus maze (EPM), social interaction and forced swim (FS) tests were then conducted in adult rats. Our results indicated that in the male cohort, early risperidone and olanzapine treatment elicited long-term hyper-locomotor effects (open-field/holeboard and FS tests), whilst a decrease in depressive-like behaviour (in FS test) was observed in response to olanzapine treatment. Furthermore, anxiolytic-like behaviours were found following testing in the open-field/holeboard and EPM in response to all three drug treatments. Effects in the female cohort, however, were to a far lesser extent, with behavioural attributes indicative of an increased depressive-like behaviour and hypo-locomotor activity exhibited in the FS test following early risperidone and olanzapine treatment. These results suggest that various APDs have different long-term effects on the behaviours of adult rats.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Early antipsychotic treatment in childhood/adolescent period has long-term effects on depressive-like, anxiety-like and locomotor behaviours in adult rats

et al. 2015

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“…Rats (n ϭ 6 -7/group) were microinjected bilaterally with vehicle (aCSF-control) or Quin (0.1 or 0.3 g) as described previously (Nowak et al, 2000). In addition, bilateral microinjections of 1.0 g of Quin into the VTA did not alter sucrose responding (Hodge et al, 1993) or prevent the acquisition of the behaviors associated with conditioned fear (de Oliveira et al, 2009). The current series of experiments did not use doses of Quin higher than 0.3 g; therefore, any effects cannot be assigned to suppression of behaviors.…”

Section: Methodsmentioning

confidence: 99%

The Posterior Ventral Tegmental Area Mediates Alcohol-Seeking Behavior in Alcohol-Preferring Rats

Hauser

Ding

Getachew

et al. 2010

J Pharmacol Exp Ther

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The mesolimbic dopamine (DA) system is involved in the rewarding process of drugs of abuse and is activated during the anticipation of drug availability. However, the neurocircuitry that regulates ethanol (EtOH)-seeking has not been adequately investigated. The objectives of the present study were to determine 1) whether the posterior ventral tegmental area (p-VTA) mediates EtOH-seeking, 2) whether microinjections of EtOH into the p-VTA could stimulate EtOH-seeking, and (3) the involvement of p-VTA DA neurons in EtOH-seeking. Alcoholpreferring rats were trained to self-administer 15% EtOH and water. After 10 weeks, rats underwent extinction training, followed by 2 weeks in their home cages. During the home-cage period, rats were then bilaterally implanted with guide cannulae aimed at the p-VTA or anterior ventral tegmental area (a-VTA).EtOH-seeking was assessed by the Pavlovian spontaneous recovery model. Separate experiments examined the effects of: 1) microinjection of quinpirole into the p-VTA, 2) EtOH microinjected into the p-VTA, 3) coadministration of EtOH and quinpirole into the p-VTA, 4) microinjection of quinpirole into the a-VTA, and 5) microinjection of EtOH into the a-VTA. Quinpirole microinjected into the p-VTA reduced EtOH-seeking. Microinjections of EtOH into the p-VTA increased EtOH-seeking. Pretreatment with both quinpirole and EtOH into the p-VTA reduced EtOH-seeking. Microinjections of quinpirole or EtOH into the a-VTA did not alter EtOH-seeking. Overall, the results suggest that the p-VTA is a neuroanatomical substrate mediating alcohol-seeking behavior and that activation of local DA neurons is involved.

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“…Our finding, that 2WAA is absent in vrDD mice when DA signaling is restored to the striatum alone, but intact when restored to both amygdala and striatum, is strong evidence for an interaction of DA signaling in these two brain regions. Pavlovian conditioning experiments have demonstrated that DA signaling in the amygdala is crucial for the establishment of associations between the conditioned stimulus and an aversive unconditioned event (Lamont and Kokkinidis 1998;Greba et al 2001;Pezze and Feldon 2004;de Oliveira et al 2009;Fadok et al 2009). DD mice are unable to learn a fear-potentiated startle response, but it can be restored with either L-Dopa or viral restoration of DA signaling in the VTA (Fadok et al 2009) or NAc and amygdala (Fadok et al 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Besides its involvement in drug-seeking, motor control, reward-learning, motivation, and attentional processes (Dayan and Balleine 2002;Schultz 2002;Dalley et al 2004;Wise 2004), the dopamine (DA) system has also been associated with fearrelated learning (Lamont and Kokkinidis 1998;Greba et al 2001;Pezze and Feldon 2004;de Oliveira et al 2009;Fadok et al 2009). DA neurons that are important for these behaviors reside predominantly in the substantia nigra pars compacta (SNc), which projects mainly to the dorsal striatum (caudate putamen, CPu), and the ventral tegmental area (VTA), which projects to the ventral striatum (nucleus accumbens, NAc), medial part of the CPu, and to cortical and limbic areas (Bjorklund and Dunnett 2007).…”

Section: Introductionmentioning

confidence: 99%

Requirement of dopamine signaling in the amygdala and striatum for learning and maintenance of a conditioned avoidance response

Darvas¹,

Fadok²,

Palmiter³

2011

Learn. Mem.

117

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Two-way active avoidance (2WAA) involves learning Pavlovian (association of a sound cue with a foot shock) and instrumental (shock avoidance) contingencies. To identify regions where dopamine (DA) is involved in mediating 2WAA, we restored DA signaling in specific brain areas of dopamine-deficient (DD) mice by local reactivation of conditionally inactivated Th genes using viral gene therapy. Among all targeted areas-prefrontal cortex (PFC), amygdala, ventral striatum, dorsal striatum, and whole striatum-only restoration of DA signaling to both the whole striatum together with the amygdala enabled DD mice to acquire 2WAA. However, after prolonged overtraining during which DD mice had DA synthesis systemically reconstituted pharmacologically with L-3,4-dihydroxyphenylalanine (L-Dopa), DA signaling in the striatum alone was sufficient to maintain 2WAA, whereas DA signaling in the PFC together with the amygdala was insufficient to maintain 2WAA. Our results indicate that learning 2WAA requires DA signaling in both the amygdala and the entire striatum; however, after sufficient training, DA signaling in the striatum alone can maintain the learned avoidance behavior.

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Role of dopamine receptors in the ventral tegmental area in conditioned fear

Cited by 56 publications

References 48 publications

Early antipsychotic treatment in childhood/adolescent period has long-term effects on depressive-like, anxiety-like and locomotor behaviours in adult rats

Early antipsychotic treatment in childhood/adolescent period has long-term effects on depressive-like, anxiety-like and locomotor behaviours in adult rats

The Posterior Ventral Tegmental Area Mediates Alcohol-Seeking Behavior in Alcohol-Preferring Rats

Requirement of dopamine signaling in the amygdala and striatum for learning and maintenance of a conditioned avoidance response

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