Role of dopamine neurotransmission in the long-term effects of repeated social defeat on the conditioned rewarding effects of cocaine

Montagud‐Romero, Sandra; Reguilón, Marina D.; Roger-Sánchez, C.; Pascual, Marı́a; Aguilar, M.A.; Guerri, Consuelo; Miñarro, José; Rodrı́guez-Arias, Marta

doi:10.1016/j.pnpbp.2016.07.008

Cited by 26 publications

(26 citation statements)

References 85 publications

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“…Differences in susceptibility to engage in depression-like behavior following repeated social defeat may be mediated by the dopamine D 1 receptor (Huang et al 2016). Pre-defeat treatment with raclopride, a D 2 -receptor antagonist, or SCH 23390, a D 1 -receptor antagonist, blocked defeat-induced potentiation of conditioned place preference for cocaine, implicating signaling at both receptors in the pathogenesis of social defeat effects (Montagud-Romero et al 2016). …”

Section: Discussionmentioning

confidence: 99%

“…In terms of understanding the neurobiological substrates of defeat effects, acute stress is known to alter the striatal circuitry that subserves reward (Porcelli et al 2012), and dopaminergic transmission previously has been shown to mediate the long-term effects of stress on reward (Montagud-Romero et al 2016, Huang et al 2016). Social defeat in adolescence leads to long-term changes in dopaminergic pathways studied in adulthood (Watt et al 2014, Burke et al 2013), a finding that could be interpreted as developmental in nature.…”

Section: Introductionmentioning

confidence: 99%

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Modeling hypohedonia following repeated social defeat: Individual vulnerability and dopaminergic involvement

Spierling

Mattock

Zorrilla

2017

Physiology & Behavior

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Social defeat in rodents putatively can model hypohedonia. The present studies examined models for assessing hypohedonia-like behavior and tested the hypotheses that 1) individual differences in baseline reward sensitivity predict vulnerability, and 2) defeat elicits changes in pharmacological measures of striatal dopaminergic function. Male Wistar rats (n=142) received repeated defeat (3 “triad” blocks of 3 defeats) or control handling. To determine whether defeat influenced consumption of SuperSac (glucose-saccharin) over an isocaloric, less preferred, glucose solution, a 2-choice paradigm was used. To determine repeated defeat effects on the reinforcing efficacy of SuperSac, a progressive-ratio schedule of reinforcement was used. Amphetamine-induced locomotor activity (0.08 mg/kg, s.c.) was determined as a measure sensitive to striatal dopaminergic function. Defeat reduced SuperSac consumption during the first two triads—an effect seen in the third triad only in defeated rats with High vs. Low baseline SuperSac intake. The characteristic escalation in PR breakpoint for SuperSac normally seen in controls was absent in defeated rats, leading to a significant difference by the third triad. Defeat-induced blunting of the escalation in PR performance was greater in rats with High antecedent PR breakpoints and persisted 2.5 weeks post-defeat. Repeated defeat also blunted amphetamine-induced locomotion 13 days post-defeat. Thus, hypohedonic-like effects of social defeat were detected and accompanied by persistently attenuated striatal dopamine function. Early effects were seen for consumption of differentially-palatable solutions, and persistent effects were seen for the “breakpoint” motivational measure. The results implicate initial reward sensitivity as a risk factor for stress-induced hypohedonia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Modeling hypohedonia following repeated social defeat: Individual vulnerability and dopaminergic involvement

Spierling

Mattock

Zorrilla

2017

Physiology & Behavior

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“…Animals are first trained to acquire CPP, and studies are in line with those using SA, with both types showing that SD increases the conditioned reinforcing properties of psychostimulants. Both acute and repeated SD induce short‐and long‐lasting increases in the conditioned rewarding effects of cocaine in mice (Hymel et al., ; Land et al., ; McLaughlin, Li, Valdez, Chavkin, & Chavkin, ; Montagud‐Romero, Reguilon et al., ; Reguilon et al., ).…”

Section: Effects Of Social Defeat On Psychostimulant and Alcohol Rewardmentioning

confidence: 99%

“…The reinstatement of CPP consists of the reappearance of the approach behavior to a drug‐associated context. Moreover, defeated animals require more sessions than nonstressed animals for the CPP to be extinguished (Montagud‐Romero, Reguilon et al., ). More information about these studies is presented in Table .…”

Section: Effects Of Social Defeat On Psychostimulant and Alcohol Rewardmentioning

confidence: 99%

“…SD stress induces pronounced physiological and endocrine responses, such as circadian rhythm disturbances and elevated levels of corticosterone (Lumley et al., ; Meerlo, Sgoifo, & Turek, ; Montagud‐Romero, Reguilon et al., ; Rodríguez‐Arias et al., ), and alteration of serotoninergic and dopaminergic neurotransmission (Hammels et al., ), among others.…”

Section: Introductionmentioning

confidence: 99%

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Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse

Montagud‐Romero

Blanco-Gandía

Reguilón

et al. 2018

Eur J of Neuroscience

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Social interaction is known to be the main source of stress in human beings, which explains the translational importance of this research in animals. Evidence reported over the last decade has revealed that, when exposed to social defeat experiences (brief episodes of social confrontations during adolescence and adulthood), the rodent brain undergoes remodeling and functional modifications, which in turn lead to an increase in the rewarding and reinstating effects of different drugs of abuse. The mechanisms by which social stress cause changes in the brain and behavior are unknown, and so the objective of this review is to contemplate how social defeat stress induces long-lasting consequences that modify the reward system. First of all, we will describe the most characteristic results of the short- and long-term consequences of social defeat stress on the rewarding effects of drugs of abuse such as psychostimulants and alcohol. Secondly, and throughout the review, we will carefully assess the neurobiological mechanisms underlying these effects, including changes in the dopaminergic system, corticotrophin releasing factor signaling, epigenetic modifications and the neuroinflammatory response. To conclude, we will consider the advantages and disadvantages and the translational value of the social defeat stress model, and will discuss challenges and future directions.

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Unravelling the Neuroinflammatory Mechanisms Underlying the Effects of Social Defeat Stress on Use of Drugs of Abuse

Montagud‐Romero

Miñarro

Rodrı́guez-Arias

2021

Neuroscience of Social Stress

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Role of dopamine neurotransmission in the long-term effects of repeated social defeat on the conditioned rewarding effects of cocaine

Cited by 26 publications

References 85 publications

Modeling hypohedonia following repeated social defeat: Individual vulnerability and dopaminergic involvement

Modeling hypohedonia following repeated social defeat: Individual vulnerability and dopaminergic involvement

Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse

Unravelling the Neuroinflammatory Mechanisms Underlying the Effects of Social Defeat Stress on Use of Drugs of Abuse

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