Role of dopamine D4 receptors in copulatory behavior: Studies with selective D4 agonists and antagonists in male rats

Sanna, Fabrizio; Contini, Andrea; Melis, Maria Rosaria; Argiolas, Antonio

doi:10.1016/j.pbb.2015.08.012

Cited by 23 publications

(20 citation statements)

References 60 publications

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“…Similar effects were observed after BNST lesion (Valcourt and Sachs, 1979). Strong reductions in intromission number were observed after serotonin 5HT1A receptor agonist (Snoeren et al, 2014) and D2 agonist and, less effectively, D1 agonist, but not D4 agonists (Cagiano et al, 1989;Beck et al, 2002;Sanna et al, 2015).…”

Section: Number Of Intromissionssupporting

confidence: 62%

The Sexual Motivation of Male Rats as a Tool in Animal Models of Human Health Disorders

Bialy

Bogacki-Rychlik

Przybylski

et al. 2019

Front. Behav. Neurosci.

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Normal or dysfunctional sexual behavior seems to be an important indicator of health or disease. Many health disorders in male patients affect sexual activity by directly causing erectile dysfunction, affecting sexual motivation, or both. Clinical evidence indicates that many diseases strongly disrupt sexual motivation and sexual performance in patients with depression, addiction, diabetes mellitus and other metabolic disturbances with obesity and diet-related factors, kidney and liver failure, circadian rhythm disorders, sleep disturbances including obstructive sleep apnea syndrome, developmental and hormonal disorders, brain damages, cardiovascular diseases, and peripheral neuropathies. Preclinical studies of these conditions often require appropriate experimental paradigms, including animal models. Male sexual behavior and motivation have been intensively investigated over the last 80 years in animal rat model. Sexual motivation can be examined using such parameters as: anticipatory behavior and 50-kHz ultrasonic vocalizations reflecting the emotional state of rats, initiation of copulation, efficiency of copulation, or techniques of classical (pavlovian) and instrumental conditioning. In this review article, we analyze the behavioral parameters that describe the sexual motivation and sexual performance of male rats in the context of animal experimental models of human health disorders. Based on analysis of the parameters describing the heterogeneous and complex structure of sexual behavior in laboratory rodents, we propose an approach that is useful for delineating distinct mechanisms affecting sexual motivation and sexual performance in selected disease states and the efficacy of therapy in preclinical investigations.

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Section: Number Of Intromissionssupporting

confidence: 62%

The Sexual Motivation of Male Rats as a Tool in Animal Models of Human Health Disorders

Bialy

Bogacki-Rychlik

Przybylski

et al. 2019

Front. Behav. Neurosci.

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“…After 30 minutes of acclimatization of each male in copulation cage, an ovariectomized female [ 20 ] made receptive by subcutaneous and sequential injections of 30 micrograms of estradiol benzoate (Sigma, USA) and 500-microgram progesterone (Bayer Pharma AG, Germany) 48 pm and 6 am, respectively, before the start of the test, was introduced in the cage. The following copulatory parameters were recorded for 1 h with reference to standard methods [ 21 – 23 ]: mounted frequency (FM) or the total number of mounts during the observation period; frequency interferences (FI) or the total number of interferences during the hour of study; frequency of ejaculations (FE) which is the total number of ejaculations; mount latency (ML) and intromission latency (IL) which are the time from intromission of a female in the cage and the first intromission and mounts, respectively; ejaculation latency which is the time between the first ejaculation and the first intromission; postejaculatory interval which is the time between the first ejaculation and the new intromission. Some additional male sexual behavior parameters computed include % mounted = (number mounted/number paired) × 100; % intromitted = (number of rats that intromitted/number paired) × 100; % index of libido = (number mated/number paired) × 100; % ejaculation = (number of rats that ejaculated/number paired) × 100; copulatory efficiency = (IF divided by MF + IF) × 100; inter-copulatory efficiency = average time between intromissions (calculated as ejaculated latency divided by intromission frequency).…”

Section: Methodsmentioning

confidence: 99%

Effects of the Aqueous Extract ofEremomastax speciosa(Acanthaceae) on Sexual Behavior in Normal Male Rats

Nchegang

Mezui

Longo

et al. 2016

BioMed Research International

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Objective. We studied prosexual effects of Eremomastax speciosa aqueous extract in male adult rats. Materials and Methods. 100 and 500 mg/kg of extract were administered orally (days 0, 1, 4, 7, 14, and 28 (posttreatment)). The sexual behavior of rats receiving a single dose (500 mg/kg) was also evaluated after pretreatment with Lω-NAME (10 mg/kg), haloperidol (1 mg/kg), or atropine (5 mg/kg). Controls received distilled water or testosterone enanthate (20 mg/kg/day/3 days (s.c.) before the test). Results. The extract (days 1–14) had no significant effect on mount, intromission, and ejaculation frequencies but on day 28 (14 days after treatment), it increased frequency of mounts and intromissions at 500 mg/kg. Mount, intromission, and ejaculation latencies reduced and postejaculatory intervals decreased but the effect did not persist 2 weeks after treatment. Extract prosex effects were greatly reduced by atropine and completely abolished by haloperidol, while Lω-NAME increased mount latency and potentiated extract effect on intromission and ejaculation latencies. Conclusion. In summary, E. speciosa extract can have positive effects on male sexual motivation and performance when administered for two weeks at the dose of 500 mg/kg. The effects (dopaminergic and/or cholinergic dependent) tend to appear during the posttreatment period.

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“…Dopamine activates oxytocinergic neurons and induces penile erection by acting on the dopamine receptors of the D2 family (D 2 , D 3 , and D 4 ), which are all present in rat PVN oxytocinergic cell bodies, see [ 120 , 121 ], and are mainly of the D 2 and D 4 subtype [ 122 , 123 , 124 , 125 ], although some controversy exists on this point [ 126 , 127 ]. Glutamic acid activates oxytocinergic neurons and induces penile erection by acting mainly on N-Methyl-D-Aspartic acid (NMDA) receptors; however, a potential role of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors cannot be ruled out [ 106 , 128 , 129 , 130 , 131 ].…”

Section: Oxytocin and Erectile Functionmentioning

confidence: 99%

Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances

Melis

Argiolas

2021

IJMS

Self Cite

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A continuously increasing amount of research shows that oxytocin is involved in numerous central functions. Among the functions in which oxytocin is thought to be involved are those that play a role in social and sexual behaviors, and the involvement of central oxytocin in erectile function and sexual behavior was indeed one of the first to be discovered in laboratory animals in the 1980s. The first part of this review summarizes the results of studies done in laboratory animals that support a facilitatory role of oxytocin in male and female sexual behavior and reveal mechanisms through which this ancient neuropeptide participates in concert with other neurotransmitters and neuropeptides in this complex function, which is fundamental for the species reproduction. The second part summarizes the results of studies done mainly with intranasal oxytocin in men and women with the aim to translate the results found in laboratory animals to humans. Unexpectedly, the results of these studies do not appear to confirm the facilitatory role of oxytocin found in male and female sexual behavior in animals, both in men and women. Possible explanations for the failure of oxytocin to improve sexual behavior in men and women and strategies to attempt to overcome this impasse are considered.

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Role of dopamine D4 receptors in copulatory behavior: Studies with selective D4 agonists and antagonists in male rats

Cited by 23 publications

References 60 publications

The Sexual Motivation of Male Rats as a Tool in Animal Models of Human Health Disorders

The Sexual Motivation of Male Rats as a Tool in Animal Models of Human Health Disorders

Effects of the Aqueous Extract ofEremomastax speciosa(Acanthaceae) on Sexual Behavior in Normal Male Rats

Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances

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