Role of diffusion weighted magnetic resonance imaging in a rat model of testicular torsion

Ufuk, Furkan; Herek, Duygu; Herek, Özkan; Akbulut, Metin

doi:10.1259/bjr.20160585

Cited by 4 publications

(6 citation statements)

References 27 publications

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“…Based on these data, a reduction of the ADCmin value is seen in the early period of testicular torsion on DWI. We suggest that ADCmin values begin to decrease in the affected testicle due to early cellular ischemia, but meanwhile, no significant change is observed in the ADCmean and ADCmax values, consistent with previous results [ 19 ]. Later, ADCmean and ADCmax values may also decrease significantly due to widespread cellular ischemia.…”

Section: Discussionsupporting

confidence: 91%

Diffusion-Weighted Imaging and Color Doppler Ultrasound in Evaluation of Partial Testicular Torsion in Rat Model

Ufuk¹,

Herek²,

Herek³

et al. 2017

pjr

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SummaryBackgroundTo evaluate the utility of histogram analysis of apparent diffusion coefficient (ADC) in the diagnosis of incomplete testicular torsion.Material/MethodsFourteen Wistar albino rats were randomly allocated into two groups. In group 1 (control), left testicles were kept outside for 45 seconds and then replaced, whereas left testicles were twisted by 360° in group 2. Four hours later, DWI was performed. After that, magnetic resonance imaging (MRI) and testicular color Doppler ultrasound (CDU) were performed by two radiologists who looked for the presence or absence of blood flow. ADC measurements were carried out by two radiologists who were blinded to each other’s measurements. After CDU, testes were surgically removed and a pathological examination was performed after four hours of torsion. Comparisons of minimum, mean, and maximum ADC values in testicles were performed with the Wilcoxon test. P value of 0.05 or less was considered as statistically significant. Inter-observer agreement was also analyzed.ResultsIn the torsion group, minimum ADC values for left testicles were significantly lower than for the control group (p<0.05), regardless of the observer. Inter-observer agreement for measurements of ADCmin and ADCmax values was substantial, with an ICC score of 0.751 and 0.774, respectively (95% CI). Inter-observer agreement for the measurement of ADCmean value was excellent, with an ICC score of 0.844 (95% CI). The pathological examination revealed mild interstitial edema and closely packed seminiferous tubules in the left testes, indicating reversible damage in the torsion group.ConclusionsOn the pathological examination, all left testes in the torsion group were recoverable after four hours of torsion. Minimum ADC values can be used as an auxiliary method in the diagnosis of partial testicular torsion. Comparing minimum ADC values between the affected and non-affected testicles can be a useful tool in the early diagnosis of incomplete testicular torsion.

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Section: Discussionsupporting

confidence: 91%

Diffusion-Weighted Imaging and Color Doppler Ultrasound in Evaluation of Partial Testicular Torsion in Rat Model

Ufuk¹,

Herek²,

Herek³

et al. 2017

pjr

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“…We speculate that the main reason was that the torsion angle in our experiment was large enough to cause a complete cessation of blood flow, and the free left testicle hindered the collateral circulation between the bilateral testicles, resulting in the early necrosis and disintegration of the tissue. Fu et al found that extensive haemorrhage resulted the ADC value significantly reduced after the testicular torsion 8 hr at 720° and 1,080°, while the ADC value significantly increased at 24 hr, suggesting that the salvageability of the testicle disappeared (Ufuk et al., 2016). In our study, however, we discovered that when the testis was twisted 720° for 4 hr, MD in the torsion group was only slightly lower than that in the sham group.…”

Section: Discussionmentioning

confidence: 99%

“…Testicular dysfunction might occur in prognosis, even it evolved into testicular atrophy (Howe et al., 2017; Lian et al., 2016). More importantly, the testicular function of the healthy side might be affected to some extent, due to the existence of bilateral testicular collateral circulation (Ufuk et al., 2016). Therefore, a clear pre‐operative diagnosis and an adequate assessment were essential to determine the time of surgery and estimate the progress of the disease.…”

Section: Introductionmentioning

confidence: 99%

“…They believed that the sensitivity of DWI was mainly related to the twist degree. The ADC value of torsion 720° decreased at 8 hr, while it increased at 24 hr, and the increased ADC value pointed to the irrecoverability of the testis (Ufuk et al., 2016). Similarly, other studies had shown that DWI played an important role in the diagnosis of scrotal diseases (Daisuke et al., 2011; Karakas et al., 2014).…”

Section: Introductionmentioning

confidence: 99%

“…collateral circulation (Ufuk et al, 2016). Therefore, a clear preoperative diagnosis and an adequate assessment were essential to determine the time of surgery and estimate the progress of the disease.…”

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Diffusion tensor imaging in evaluating testicular injury after unilateral testicular torsion and detorsion in rat model: A preliminary study

Zhou

Cheng

et al. 2021

Andrologia

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Diffusion tensor imaging (DTI) is a functional magnetic resonance sequence based on the movement of water molecules. This study attempted to investigate the feasibility of DTI in evaluating testicular injury after testicular torsion and detorsion. Seventy‐two rats were randomly divided into the sham group, torsion group and detorsion group. The left testis in the sham group was brought out through a scrotal incision for 1 hr, and that of the torsion group was twisted 720o clockwise for 1 hr and fixed to the scrotum, while the detorsion group was restored after being twisted 720° for 1 hr. Rats were further divided into four subgroups according to the set time, then performed DTI and histology analysis. The mean diffusion of the torsion and detorsion groups increased within 24 hr (p <.01), while it in the detorsion‐1‐week‐group was lower than that in the detorsion‐24‐hr‐group (p <.05). The fraction anisotropy of both experimental groups decreased in the acute phase (p <.01), while that of the detorsion‐1‐week‐group increased (p <.01). Cosentino score in both experimental groups showed an increasing trend (p <.05). Besides, the spermatogenic ability of the detorsion‐1‐week‐group decreased (p <.05). In conclusion, DTI was able to evaluate the injury after testicular torsion and detorsion.

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Samarcandin protects against testicular ischemia/reperfusion injury in rats via activation of Nrf2/HO-1-mediated antioxidant responses

Abdel‐Kader

Abdel-Rahman

Althurwi

et al. 2023

Saudi Pharmaceutical Journal

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Role of diffusion weighted magnetic resonance imaging in a rat model of testicular torsion

Cited by 4 publications

References 27 publications

Diffusion-Weighted Imaging and Color Doppler Ultrasound in Evaluation of Partial Testicular Torsion in Rat Model

Diffusion-Weighted Imaging and Color Doppler Ultrasound in Evaluation of Partial Testicular Torsion in Rat Model

Diffusion tensor imaging in evaluating testicular injury after unilateral testicular torsion and detorsion in rat model: A preliminary study

Samarcandin protects against testicular ischemia/reperfusion injury in rats via activation of Nrf2/HO-1-mediated antioxidant responses

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