Role of diffusion weighted imaging and dynamic contrast enhanced MR mammography to detect recurrence in breast cancer patients after surgery

El-nasr, Safaa Ibrahim Saif; Rahman, Rasha Wessam Abdel; Abdelrahman, Sherif Fathy; Helal, M. A.; Hamed, Soha Talaat

doi:10.1016/j.ejrnm.2016.04.008

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…NPV. In agreement, Saif El-nasr et al [13] reported that DCE-MRI showed 100% sensitivity, 93.9% specificity, 93.1% 'PPV', 100% 'NPV' and 96.7% accuracy in differentiating postoperative changes and related treatment changes from true recurrence.…”

Section: Discussionsupporting

confidence: 54%

Sonomammograhy versus MRI diffusion in evaluation of suspicious breast lesions

mohamed¹,

yakout

Ahmed

2022

Journal of Recent Advances in Medicine

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Background: Breast cancer is the most frequent cancer in women and the second leading cause of death among them. Breast lesions were first categorized as benign or cancerous.Objective: was to highlight the role of noninvasive diagnostic breast modalities including mammography, ultrasound, conventional MRI and MRI diffusion imaging in detection and characterization of suspicious breast lesions.Methodology: It was a hospital based cross sectional study done on total number of 50 female patients presented by breast lump or nipple discharge, some of them were referred from surgical department and others from out-patient clinic to the radiology department at Met Ghamr oncology center, after receiving clearance from the institute's ethical council, the study was carried out for two years, from June 2019 to August 2021. Before being included in the trial, all patients provided informed permission. They were subjected for imaging by digital mammography, ultrasonography and MRI mammography. Results:The study revealed that in the evaluation and description of worrisome breast lesions, MRI mammography plays a leading role over digital mammography and ultrasonography. Conclusion:MRI mammography outperformed digital mammography and ultrasonography regarding of sensitivity, specificity, and diagnostic performance.

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Section: Discussionsupporting

confidence: 54%

Sonomammograhy versus MRI diffusion in evaluation of suspicious breast lesions

mohamed¹,

yakout

Ahmed

2022

Journal of Recent Advances in Medicine

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“…It not only has shown to give near to 100% (95% CI: 93 -100%) prediction of benign lesions, which means that no further invasive diagnostic work-up is needed, it also gives a better prediction of malignant lesions (16) . For many years, MRI examination has been widely accepted as a diagnostic tool for evaluation of breast cancer, one of its indications, is the differential diagnosis between cancer recurrence and surgical scar, Saif El-nasr et al reported that DCE-MRI showed 100% sensitivity, 93.9% specificity, 93.1% 'PPV', 100% 'NPV' and 96.7% accuracy in differentiating postoperative changes and related treatment changes from true recurrence (17) . In our study there were 2 cases who underwent lumpectomy and developed postoperative lump after operation, first one after 1 year and the second after 3 months.…”

Section: Discussionmentioning

confidence: 99%

Sonomammography versus MRI in Evaluation of BI-RADS III Breast Lesion

Helmy

2018

The Egyptian Journal of Hospital Medicine

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Background: Breast cancer is sometimes found after symptoms appear, but many women with breast cancer have no symptoms. This is why regular breast cancer screening is so important, early detection and treatment are the most important strategies to prevent deaths from breast cancer. Breast cancer that's found early, when it's small and has not spread, is easier to treat successfully, regular screening tests are the most reliable way for early detection. Objective: to high light the role of sonomammography versus Magnetic Resonance Imaging (MRI) in evaluation of BI-RADS III (Breast Imaging Reporting and Data System) breast lesion. Patients and Methods: in this retrospective study, 28 patients with BI-RADS III breast lesion were assessed by Digital mammography (DM), Ultrasound (US) and MRI. The resultant images were correlated with reports of the pathology specimens. Results: histopathological analysis was done for each lesion with 13 lesions (46.43%) proved to be benign, 15 lesions (53.57%) proved to be malignant. The sensitivity, specificity, Positive predictive value (PPV) and Negative predictive value (NPV) of mammography (MG), ultrasonography and MRI in BI-RADS III breast lesions were calculated. Conclusion: BI-RADS III lesions group is a very critical group to deal with as it exhibits characters of both malignant and benign lesions. According to our study Dynamic contrast enhanced-Magnetic Resonance Imaging. (DCE-MRI) should go hand by hand with sonomammogaphy especially in BI-RADS III patients group, patients with benign looking lesion six months follow up is recommended and those with malignant looking lesion biopsy should be done.

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“…Of note, our results also match those of El-nasr et al . ( b -values of 0, 50, and 850 s/mm 2 ): the mean ADC value of the benign breast lesions (1.2 ± 0.34 × 10 −3 mm 2 /s) was statistically higher than that of the post-operative recurrent malignant lesions (0.83 ± 0.15 × 10 −3 mm 2 /s), while the mean ADC value in cases of post-op fibrosis was lowest among those subgroups and amounted to 0.77 ± 0.2 × 10 −3 mm 2 /s [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Local recurrence of renal cell carcinoma after partial nephrectomy: applicability of the apparent diffusion coefficient of MRI as an imaging marker – a multicentre study

et al. 2022

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Purpose The goal of the study was an assessment of the diagnostic performance of diffusion-weighted images (DWI) and apparent diffusion coefficient (ADC) of magnetic resonance imaging (MRI) in distinguishing local recurrence (LR) of renal cell carcinoma (RCC) from benign conditions after partial nephrectomy. Material and methods Thirty-nine patients after partial nephrectomy for solid RCC were enrolled in the study. Patients were followed up using MRI, which included DWI sequence ( b = 800 s/mm 2 ). All patients with MRI features of LR were included in the main group ( n = 14) and patients without such features – into the group of comparison ( n = 25). Apparent diffusion coefficient (ADC) values of suspicious lesions were recorded. In all patients with signs of locally recurrent RCC, surgical treatment was performed followed by pathologic analysis. Results The mean ADC values of recurrent RCC demonstrated significantly higher numbers compared to benign fibrous tissues and were 1.64 ± 0.15 × 10 -3 mm 2 /s vs. 1.02 ± 0.26 × 10 -3 mm 2 /s ( p < 0.001). The mean ADC values of RCCs’ LR and benign post-op changes in renal scar substantially differed from mean ADC values of healthy kidneys’ parenchyma; the latter was 2.58 ± 0.05 × 10 -3 mm 2 /s ( p < 0.001). In ROC analysis, the use of ADC with a threshold value of 1.28 × 10 -3 mm 2 /s allowed us to differentiate local recurrence of RCC from benign postoperative changes with 100% sensitivity, 80% specificity, and accuracy: AUC = 0.980 ( p < 0.001). Conclusions The apparent diffusion coefficient of DWI of MRI can be used as a potential imaging marker for the diagnosis of local recurrence of RCC.

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Role of diffusion weighted imaging and dynamic contrast enhanced MR mammography to detect recurrence in breast cancer patients after surgery

Cited by 5 publications

References 13 publications

Sonomammograhy versus MRI diffusion in evaluation of suspicious breast lesions

Sonomammograhy versus MRI diffusion in evaluation of suspicious breast lesions

Sonomammography versus MRI in Evaluation of BI-RADS III Breast Lesion

Local recurrence of renal cell carcinoma after partial nephrectomy: applicability of the apparent diffusion coefficient of MRI as an imaging marker – a multicentre study

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