Role of dental hardware in oral cavity squamous cell carcinoma in the low‐risk nonsmoker nondrinker population

Abstract

Exposure to metallic dental hardware has increased in the past few decades given the rise of orthodontic braces and older adults retaining more teeth. Although this study does not prove a causal relationship between oral cavity SCC and dental hardware, this is a step toward identifying and investigating their role.

Epidemiological profile and clinical implications of oral squamous cell carcinoma adjacent to dental implants

“…Oral squamous cell carcinoma adjacent to DI was first reported in 1983 (Friedman & Vernon, 1983), and since then several other cases have been described in the literature (Bhatavadekar, 2012;Gulati et al, 2009;Kaplan et al, 2017;Kwok et al, 2008;Moergel et al, 2014;Moergel et al, 2014;Schache et al, 2008;Yesensky et al, 2018). OSCC adjacent to DI is estimated at 0.00017/ million/ year in the United States of America (USA) (Yesensky et al, 2018) and represents only 1.5% of oral cancer (Kaplan et al, 2017). DI is very important in prosthetic rehabilitation worldwide, and it is estimated that this market will profit about US $ 9.8 billion by 2022 (The Global Dental Implant & Prosthetic Market, 2020).…”

“…Chronic inflammation caused by persistent trauma to the peri-implant soft tissues, nutritional deficiencies (Jané-Salas et al, 2012) autoimmune diseases (Robbins et al, 2002), and the leaching of metal ions into the oral cavity has been speculated as potential etiologic factors for OSCC development adjacent to DI (Hafez et al, 2011;Ortiz et al, 2011;Yesensky et al, 2018). The correlation between chronic inflammation and malignancy has been found for some types of tumors, such as Barret's esophagitis and esophageal cancer (Yousef et al, 2008), and Crohn's disease and colon cancer (Jess et al, 2005).…”

“…The mechanism underlying the occurrence of OSCC adjacent to DI is not yet well established. It has been suggested that metallic nanoparticles could induce inflammatory effects due to their immunomodulatory capacity, causing damage to DNA (Hafez et al, 2011;Ortiz et al, 2011;Yesensky et al, 2018). Leaching of metal ions in the oral cavity can occur due to friction during implant insertion, friction at the implant-abutment interface, corrosion of the implant surface, among others (Suárez-López del Amo et al, 2018).…”

Molecular drivers of oral cavity squamous cell carcinoma in non-smoking and non-drinking patients: what do we know so far?

“…18 Evidence suggests a bimodal age distribution, with most NSND OCSCC found in distinct 'younger' and 'older' age cohorts when compared to traditional smoking/drinking (SD) patients. [28][29][30][31] For example, in a study of 128 SD and 41 NSND patients with new or recurrent OCSCC, Koo et al noted a bimodal age distribution with peaks at 50-59 and 70-79 years in NSND, but a single peak at 60-69 years in SD patients. 24 Further, in a retrospective cohort study of 172 NSND and 1131 ever-smoking ever-drinking (ESED) patients newly diagnosed with HNSCC, Dahlstrom et al 28 found that 41% of NSND were under 50 years old, compared with only 22% of ESED.…”

Inhibition of CAL27 Oral Squamous Carcinoma Cell by Targeting Hedgehog Pathway With Vismodegib or Itraconazole

“…According to the classification criteria for oral cavity and oropharynx tumors established by the World Health Organization (8), OSCC is considered an invasive and aggressive epithelial neoplasia with the potential to promote early metastasis and extensive lymph node involvement. This disease mainly affects adult population aged 50 to 60 years old and has a multifactorial etiology, with the principal risk factors being tobacco and alcohol use (9)(10)(11)(12). A 5-year survival rate has been reported in approximately 50% of OSCC cases (3,13).…”