Role of dendritic cells in progression and clinical outcome of colon cancer

Gulubova, Maya; Ananiev, Julian; Vlaykova, Tatyana; Yovchev, Y.; Tsoneva, Vanya; Manolova, Irena

doi:10.1007/s00384-011-1334-1

Cited by 84 publications

(84 citation statements)

References 33 publications

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“…DCs were identifi ed as the HLA-DR ( ϩ )/CD83 ( ϩ ) positive cells by Schwaab et al (2001). Cells stained with S-100, HLA-DR, CD1a or CD83 were considered to be DCs by Gulubova et al (2012). Finally Nagorsen et al (2007) classifi ed DCs as S-100 ϩ /CD163 ϩ double-stained cells.…”

Section: Methods Used To Identify the Dcsmentioning

confidence: 99%

“…Full-text review of these resulted in four exclusions that included three review papers and one study investigating the DCs at the invasive margin of CRC but not associating with outcomes. Eight studies were judged to be eligible in this review, all of which were cohort studies (evidence grade C based on the SIGN grading system) (Ambe et al, 1989;Schwaab et al, 2001;Gulubova et al, 2012;Nagorsen et al, 2007;Sandel et al, 2005;Nakayama et al, 2003;Dadabayev et al, 2004;Liska et al, 2012). A total of 651 specimens, all diagnosed with CRC at all stages, were included.…”

Section: Search Outcomesmentioning

confidence: 99%

“…Two studies have endeavoured to assess the maturation status of TIDCs by staining for CD83, a DC-specifi c maturation marker expressed by all mature subsets (Ambe et al, 1989;Gulubova et al, 2012). Two studies have also used molecules such as DC-lysosome-associated membrane protein (LAMP) and DC-SIGN as maturation markers (Nagorsen et al, 2007;Sandel et al, 2005).…”

Section: Populations Studiedmentioning

confidence: 99%

“…Six of the selected studies identifi ed DCs in the tumour margin area (Ambe et al, 1989;Schwaab et al, 2001;Gulubova et al, 2012;Nagorsen et al, 2007;Sandel et al, 2005;Nakayama et al, n.d.;Dadabayev et al, 2004;Liska et al, 2012). Gulubova et al (2012) and Nagorsen et al (2007) included tumour stroma and tumour epithelium.…”

Section: Location Identifi Cationmentioning

confidence: 99%

“…Gulubova et al (2012) and Nagorsen et al (2007) included tumour stroma and tumour epithelium. The latter study also assessed the tumour epithelium for the presence of TIDCs.…”

Section: Location Identifi Cationmentioning

confidence: 99%

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Prognostic Value of the Tumour-Infiltrating Dendritic Cells in Colorectal Cancer: A Systematic Review

Malietzis

Lee

Jenkins

et al. 2015

Cell Communication & Adhesion

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Dendritic cells (DCs) either boost the immune system (enhancing immunity) or dampen it (leading to tolerance). This dual effect explains their vital role in cancer development and progression. DCs have been tested as a predictor of outcomes for cancer progression. Eight studies evaluated tumour-infi ltrating DCs (TIDCs) as a predictor for colorectal cancer (CRC) outcomes. The detection of TIDCs has not kept pace with the increased knowledge about the identifi cation of DC subsets and their maturation status. For that reason, it is diffi cult to draw a conclusion about the performance of DCs as a predictor of outcome for CRC. In this review, we comprehensively examine the evidence for the in situ immune response due to DC infi ltration, in predicting outcome in primary CRC and how such information may be incorporated into routine clinical assessment.

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Section: Methods Used To Identify the Dcsmentioning

confidence: 99%

Section: Search Outcomesmentioning

confidence: 99%

Section: Populations Studiedmentioning

confidence: 99%

Section: Location Identifi Cationmentioning

confidence: 99%

“…Gulubova et al (2012) and Nagorsen et al (2007) included tumour stroma and tumour epithelium. The latter study also assessed the tumour epithelium for the presence of TIDCs.…”

Section: Location Identifi Cationmentioning

confidence: 99%

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Prognostic Value of the Tumour-Infiltrating Dendritic Cells in Colorectal Cancer: A Systematic Review

Malietzis

Lee

Jenkins

et al. 2015

Cell Communication & Adhesion

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Determinants of metastatic competency in colorectal cancer

et al. 2017

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Colorectal cancer (CRC) is one of the most common cancer types and represents a major therapeutic challenge. Although initial events in colorectal carcinogenesis are relatively well characterized and treatment for early‐stage disease has significantly improved over the last decades, the mechanisms underlying metastasis – the main cause of death – remain poorly understood. Correspondingly, no effective therapy is currently available for advanced or metastatic disease. There is increasing evidence that colorectal cancer is hierarchically organized and sustained by cancer stem cells, in concert with various stromal cell types. Here, we review the interplay between cancer stem cells and their microenvironment in promoting metastasis and discuss recent insights relating to both patient prognosis and novel targeted treatment strategies. A better understanding of these topics may aid the prevention or reduction of metastatic burden.

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