Role of cytokines in lavage or drainage fluid after hemithyroidectomy in wound healing: Involvement of histamine in the acceleration and delay of wound healing

Arai, Miku; Ogita-Nakanishi, Hiromi; Lee, Koutetsu; Yoshimura, Katsuhiro; Kawata, Ryo; Kanazawa, Atsuko; Takato, Tsuyoshi; Takenaka, Hiroshi; Sato, Tadasu; Endo, Yasuo; Kato, Ryuichi; Ijiri, Yoshio; Tanaka, Kazuhiko; Tashiro-Yamaji, Junko; Kubota, Takeshi; Yoshida, Ryotaro

doi:10.1111/j.1524-475x.2012.00770.x

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Vacuum, drainage, or other external devices were used in 124 of the 280 (44%) studies and thus were the most frequently used methods of sample collection 22–27,29–146 ; the vast majority of sample collections using this method (75%, 103/138), were from surgical wounds (Figure 2B). Three other frequently used methods were extraction from absorbent material (31%, 86/280),…”

Section: Resultsmentioning

confidence: 99%

Wound fluid sampling methods for proteomic studies: A scoping review

Harvey

Mellody

Cullum

et al. 2022

Wound Repair Regeneration

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Understanding why some wounds are hard to heal is important for improving care and developing more effective treatments. The method of sample collection used is an integral step in the research process and thus may affect the results obtained. The primary objective of this study was to summarise and map the methods currently used to sample wound fluid for protein profiling and analysis. Eligible studies were those that used a sampling method to collect wound fluid from any human wound for analysis of proteins. A search for eligible studies was performed using MEDLINE, Embase and CINAHL Plus in May 2020. All references were screened for eligibility by one reviewer, followed by discussion and consensus with a second reviewer.Quantitative data were mapped and visualised using appropriate software and summarised via a narrative summary. After screening, 280 studies were included in this review. The most commonly used group of wound fluid collection methods were vacuum, drainage or use of other external devices, with surgical wounds being the most common sample source. Other frequently used collection methods were extraction from absorbent materials, collection beneath an occlusive dressing and direct collection of wound fluid. This scoping review highlights the variety of methods used for wound fluid collection. Many studies had small sample sizes and short sample collection periods; these weaknesses have hampered the discovery and validation of novel biomarkers. Future research should aim to assess the reproducibility and feasibility of sampling and analytical methods for use in larger longitudinal studies.

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Section: Resultsmentioning

confidence: 99%

Wound fluid sampling methods for proteomic studies: A scoping review

Harvey

Mellody

Cullum

et al. 2022

Wound Repair Regeneration

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“…Bioactive factors like serotonin, histamine, dopamine, calcium and adenosine are present in the dense granules of the platelets [22]. These non-growth factors have fundamental [23] effect on the biologic aspects of wound healing. Histamine and serotonin when released by the platelets increase capillary permeability, which in turn allows inflammatory cells a greater access to the wound site and resultant macrophage activation.…”

Section: Scientific Rationalementioning

confidence: 99%

Platelet Derived Biomaterials for Therapeutic Use: Review of Technical Aspects

Arora

Agnihotri

2016

Indian J Hematol Blood Transfus

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Whole blood is composed of both cellular and plasma components, providing a rich source of therapeutic products. Of late, platelet derived biomaterial (platelet rich plasma) consisting of plasma proteins and platelets are increasingly being used for various indications. Protocols for preparation and nomenclature of this biomaterial vary widely amongst authors and are often not well defined. Additionally, they are not uniformly documented in the literature, making results difficult to compare or replicate. In this paper we review the evolution and type of these products available for clinical use. Further we will discuss the scientific rational and technical aspects in preparation of these platelet biomaterials in order to administer them in various fields of medicine.

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“…The administration of histamine, or its liberators, accelerated the production and polymerization of collagen within granulation tissue in guinea pigs [9] and rats [10]. The healing rate has also been found to be inversely proportional to the level of histamine, which appears to regulate the progression of the healing process [11].…”

Section: Introductionmentioning

confidence: 95%

Histamine augments collagen content via H1 receptor stimulation in cultures of myofibroblasts taken from wound granulation tissue

et al. 2020

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The inflammatory reaction influences the deposition of collagen within wound granulation tissue. The aim of the present study is to determine whether histamine acting directly on myofibroblasts derived from wound granulation tissue may influence collagen deposition. It also identifies the histamine receptor involved in this process. The experiments were carried out on cells isolated from the granulation tissue of a wound model (a polypropylene net inserted subcutaneously to rats) or intact rat skin. Collagen content was measured following the addition of different concentrations of histamine and treatment with histamine receptor antagonists (ketotifen – H1 inhibitor, ranitidine – H2 inhibitor) and a histamine receptor H1 agonist (2-pyridylethylamine dihydrochloride).The cells were identified as myofibroblasts: alpha-smooth muscle actin, vimentin, and desmin positive in all experimental conditions. Histamine increased the collagen level within both cell cultures, i.e., those isolated from granulation tissue or intact skin. It did not, however, influence the expression of either the collagen type I or III genes within the cultured myofibroblasts. Histamine activity was reduced by ketotifen (the H1 receptor inhibitor) and increased by the H1 receptor agonist, as demonstrated by changes in the levels of collagen in the myofibroblast culture. Histamine increased collagen content within the cultures, acting directly on myofibroblasts via H1 receptor stimulation.

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Role of cytokines in lavage or drainage fluid after hemithyroidectomy in wound healing: Involvement of histamine in the acceleration and delay of wound healing

Cited by 4 publications

References 22 publications

Wound fluid sampling methods for proteomic studies: A scoping review

Wound fluid sampling methods for proteomic studies: A scoping review

Platelet Derived Biomaterials for Therapeutic Use: Review of Technical Aspects

Histamine augments collagen content via H1 receptor stimulation in cultures of myofibroblasts taken from wound granulation tissue

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