Role of Cystitis Cystica et Glandularis and Intestinal Metaplasia in Development of Bladder Carcinoma

Smith, Arthur L.; Hansel, Donna E.; Jones, J. Stephen

doi:10.1016/j.urology.2007.11.079

Cited by 99 publications

(111 citation statements)

References 18 publications

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“…Where as cystoscopy is indicated in patients with persistent LUTS, hematuria, increase in size of lesions on ultrasound or with risk factors for carcinoma bladder. Patients with mucus secretions, intestinal metaplasia [1,10] , pelvic lipomatosis [1,11,12] should be kept on a close follow up protocol, which includes cystoscopy at 6 monthly intervals. …”

Section: Resultsmentioning

confidence: 99%

“…The literature mentions that TUR resection of the lesions and treatment of precipitating factors is required for these lesions [1] . Also regular follow up with ultrasonography and cystoscopy is indicated for the fear of malignant transformation that might rarely occur [10,13] .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, patients with mucus secretions, intestinal metaplasia and pelvic lipomatosis need close surveillance with cystoscopy as malignant transformation of cystitis cystica is reported in these lesions [10][11][12][13] .…”

Section: Discussionmentioning

confidence: 99%

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Cystitis cystica mimicking as bladder tumour

Bapat¹,

Shah²,

Talaulikar³

et al. 2012

JBGC

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Objective: We present our experience of managing six cases of cystitis cystica, which mimicked a bladder tumour. Materials and Methods: Six cases of cystitis cystica were diagnosed over a period of five years (2005)(2006)(2007)(2008)(2009)(2010)(2011). Age varied from 26 to 54 years of which four patients were male and two were females. All of them presented with lower urinary tract symptoms (LUTS), urinary tract infection (UTI) in 3 patients and mild intermittent hematuria in 2 patients. Clinical examination and routine laboratory tests were normal except for presence of leucocytes and blood in urine. Ultrasound (USG) revealed thickened bladder wall with polypoidal lesions suspicious of malignancy. Urinary cytology was negative for malignant cells. Cystoscopy revealed multiple papillary lesions arising from the bladder neck and trigone. There was conspicuous absence of a blood vessel core in the centre of the papillary fronds. Transurethral biopsy of the bladder lesion revealed cystitis cystica with no evidence of malignancy. Four out of six patients responded well to conservative treatment with long-term oral antibiotics as per the culture and sensitivity reports. Transurethral resection was required in only two patients due to lesions causing obstructive symptoms. Patients were followed up with history and clinical examination, urinary cytology and ultrasonographic monitoring of the lesions. Results:Of the six cases TUR, resection was required in only 2 patients with obstructing lesions and remaining 4 were managed conservatively. Conclusion:Cystitis cystica is a rare benign condition that can mimic bladder tumour. Cystoscopic appearance is typical and biopsy confirms the diagnosis. Treatment is usually conservative. TUR resection is required in selected cases. Long-term follow up is essential, as cystitis cystica is a premalignant disease of the urinary bladder.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cystitis cystica mimicking as bladder tumour

Bapat¹,

Shah²,

Talaulikar³

et al. 2012

JBGC

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“…3,4 They are common lesions in 60% to 70% of autopsy cases 5 and 0.1% to 1.9% in the clinical setting. 6 They are most common in the trigone region of the bladder, but may be extensive.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 In addition, the prognosis of CG is undetermined, with cases of widespread CG progressing to adenocarcinoma. 3 This study was undertaken to evaluate the morphology of CG and to highlight the difference in morphology between CG and adenocarcinoma. A recent study found that CG was not a premalignant lesion and did not need frequent cystoscopic examination.…”

Section: Discussionmentioning

confidence: 99%

The role of steroid treatment in intractable cystitis glandularis: A case report and literature review

Yüksel

Ürkmez

Erdoğru

et al. 2015

CUAJ

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Cystitis glandularis is a proliferative disease of the urinary bladder epithelium. It is rare in children. We report a case of a 23-yearold female with intractable macroscopic hematuria and severe irritative bladder symptoms persisting for 13 years. The patient, who had undergone open and endoscopic bladder surgery at various medical centres, is currently being followed up at our clinic. Cystoscopy revealed multiple edematous papillary tumours on the bladder neck, trigone, and lateral wall on both sides and she underwent transurethral resection of the bladder tumour. The pathological diagnosis was cystitis glandularis in accordance with the histopathological reports obtained from the other medical centres. Her condition was resistant to transurethral resection, partial cystectomy, intravesical mitomycin, and bacillus Calmette-Guerin (BCG) treatment; it eventually could have affected the upper urinary tract. Oral steroid treatment was given for 6 months; after treatment, her symptoms improved and the cystoscopy revealed a dramatic improvement in her condition.

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