Role of curcumin in selected head and neck lesions. Limitations on the use of the Hep-2 cell line: A critical review

Piwowarczyk, Ludwika; Stawny, Maciej; Piwowarczyk, Krzysztof; Mlynarczyk, Dariusz T.; Muszalska-Kolos, Izabela; Wierzbicka, Małgorzata; Gośliński, Tomasz; Jelińska, Anna

doi:10.1016/j.biopha.2022.113560

Cited by 3 publications

(1 citation statement)

References 59 publications

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“…Using compounds derived from plants is a promising approach to create novel anticancer therapeutics [79]. Curcumin was proven to exhibit activity against various types of cancer-it influences carcinogenesis and apoptosis while being safe and non-toxic [2,8,[79][80][81]. Again, the factors hampering its broader use are its unfavorable physico-chemical properties.…”

Section: Cancermentioning

confidence: 99%

Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin?

Stachowiak,

Mlynarczyk,

Dlugaszewska

2024

Molecules

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Curcumin is a natural compound with a great pharmaceutical potential that involves anticancer, anti-inflammatory, antioxidant, and neuroprotective activity. Unfortunately, its low bioavailability, instability, and poor water solubility significantly deteriorate its clinical use. Many attempts have been made to overcome this issue, and encapsulating curcumin in a hydrogel matrix may improve those properties. Hydrogel formulation is used in many drug delivery forms, including classic types and novel forms such as self-assembly systems or responsive to external factors. Reviewed studies confirmed better properties of hydrogel-stabilized curcumin in comparison to pure compound. The main enhanced characteristics were chemical stability, bioavailability, and water solubility, which enabled these systems to be tested for various diseases. These formulations were evaluated for wound healing properties, effectiveness in treating skin diseases, and anticancer and regenerative activity. Hydrogel formulation significantly improved biopharmaceutical properties, opening the opportunity to finally see curcumin as a clinically approved substance and unravel its therapeutic potential.

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Section: Cancermentioning

confidence: 99%

Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin?

Stachowiak,

Mlynarczyk,

Dlugaszewska

2024

Molecules

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Chemical modification of curcumin increases its potency against hypopharyngeal carcinoma

Zhang¹,

Liu

Chen

et al. 2023

Journal of Drug Targeting

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Earlier laryngeal cancer detection using hybrid M-RCNN technique

Sharmila Joseph,

Vidyarthi

2024

IFS

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One of the most common types of cancer is Laryngeal cancer, which has a high mortality rate. The primary malignant tumor responsible for this disease is squamous cell carcinoma (SCC). Early diagnosis is very important to avoid experiencing morbidity and mortality. Various tools and techniques are used to detect and monitor laryngeal cancers. Unfortunately, these tools and techniques have various limitations, for example, Existing tools and approaches Mask R-CNN for identifying laryngeal cancer have various performance limitations. These include the inability to accurately identify the disease in its early stages, the complexity of the computational environment, and the time-consuming process of conducting patient screenings by utilizing diverse image datasets, but it lagging to detect large dataset. In this paper, we present a hybrid deep-learning model which can be used to analyze and monitor the different symptoms of laryngeal cancers. Proposed model takes Laryngeal cancer dataset as input; preprocessing is done using median filter, then data augmentation is applied to increase data diversity, then feature extraction is performed using LBP-KNN, finally cancer identification/classification is done using Mask-RCNN. Proposed model attains Accuracy:99.3% ; Precision:97.99% ; Recall:98.09% and F-measure: 97.01%. This method could be useful in providing clinical support to radiologists and doctors. The proposed model can be used to detect minor malignancies in patients in a fast and accurate manner. It can also help improve the efficiency of the clinical process by allowing clinicians to screen more patients.

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Role of curcumin in selected head and neck lesions. Limitations on the use of the Hep-2 cell line: A critical review

Cited by 3 publications

References 59 publications

Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin?

Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin?

Chemical modification of curcumin increases its potency against hypopharyngeal carcinoma

Earlier laryngeal cancer detection using hybrid M-RCNN technique

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