Chemical modification of curcumin increases its potency against hypopharyngeal carcinoma

Zhang, Linlin; Liu, Cheng; Chen, Zhi Hao; Fu, Yi; Li, Changjiang; Chen, Min; He, Peng; Wu, Haitao; Wu, Jianzhang; Chen, Jian

doi:10.1080/1061186x.2023.2247581

Cited by 1 publication

(1 citation statement)

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“…Researchers have used a variety of methods to address this challenge, such as chemical modification [11], nanotechnology [12,13], and the use of natural synergists [14]. In this review, we summarize the molecular mechanism of CCM on inflammatory bowel disease (IBD), gastric ulcers, and colon cancer, and evaluate and predict the clinical efficacy of CCM formulations based on the existing studies.…”

Section: Introductionmentioning

confidence: 99%

Advancing Gastrointestinal Health: Curcumin’s Efficacy and Nanopreparations

Ji,

Ma,

Wang

2024

Molecules

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Curcumin (CCM) is a polyphenol compound extracted from the turmeric rhizome. It has various biological activities, including antibacterial, anti-inflammatory, anti-cancer, and antioxidant. Due to its diverse activities, it is often used by researchers to study the therapeutic effects on various diseases. However, its poor solubility leads to poor bioavailability, and it is necessary to increase the water solubility with the help of carriers to improve the therapeutic effect. Gastrointestinal disease is a major global health problem that continues to affect human health. In this review, we have summarized the possible mechanism and therapeutic effect of CCM in various gastrointestinal diseases, and the improvement in the curative effect of CCM with nanopreparation. Finally, we concluded that there have been many clinical trials of CCM in combination with other drugs for the treatment of gastrointestinal disease, but so far, few have used CCM nanomaterials for treatment. Although in vitro and preclinical experiments have shown that nanopreparations can improve the efficacy of CCM, there are still insufficient studies on the safety of carriers.

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