Role of curcumin in preventing familial adenomatous polyposis

Majumdar, Adhip P. N.

doi:10.21037/dmr.2018.09.01

Cited by 2 publications

(1 citation statement)

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“…The term colon cancer is often used synonymously with colorectal or rectal cancer because they exhibit very similar features. Most of the colon cancers begin with a mutation in the APC gene (adenomatous polyposis coli) which causes normal mucosal cells to transform into ACF (aberrant crypt foci, which are the earliest pre-malignant lesions) and eventually into adenomas 2,3 . Certain established risk factors for colon cancer include lifestyle factors (obesity, smoking, physical inactivity), dietary factors (low consumption of whole grains/dietary fiber, high intake of red and processed meats, alcohol consumption) and genetic factors 1,4 .…”

Section: Introductionmentioning

confidence: 99%

Curcumin and Colon Cancer

Badiger¹

2020

Preprint

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Curcumin, derived from turmeric (Curcuma longa) has been extensively studied andvalued for its anti-cancer properties. It acts against a wide range of cancers by hindering the sixmain traits of all cancers, and the most prominent mechanisms include targeting inflammatorypathways. However, since curcumin has low bioavailability, most of it is excreted causing lowsystemic levels, but measurable concentrations in the colonic mucosa. Consequently, colon cancer,which has a high rate of incidence, is one of the more suited targets for curcumin action. The aimof this review is to summarize the mechanisms of curcumin in colon cancer with an emphasis onclinical studies, bioavailability and speculations about turmeric.

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Section: Introductionmentioning

confidence: 99%

Curcumin and Colon Cancer

Badiger¹

2020

Preprint

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Curcumin - A Novel Therapeutic Agent in the Prevention of Colorectal Cancer

Gupta

Vadde

Sarojamma

2020

CDM

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Background: Colorectal cancer is the third important cause of cancer-associated deaths across the world. Hence, there is an urgent need for understanding the complete mechanism associated with colorectal cancer, which in turn can be utilized toward early detection as well as the treatment of colorectal cancer in humans. Though colorectal cancer is a complex process and chemotherapy is the first step toward the treatment of colorectal cancer, recently several studies suggested that dietary phytochemicals may also aid significantly in reducing colorectal cancer risk in human. However, only few phytochemicals, specifically curcumin derived from the rhizomes of Curcuma longa, have better chemotherapeutic property, which might be because of its ability to regulate the activity of key factors associated with the initiation, promotion, as well as progression of tumors. Objectives: In the present review, the authors made an attempt to summarize the physiochemical properties of curcumin, which in turn prevent colorectal cancer via regulating numerous cell signaling as well as genetic pathways. Conclusions: Accumulated evidence suggested that curcumin suppresses tumour/colon cancer in various ways, (a) restricting cell cycle progression, or stimulating apoptosis, (b) restricting angiogenesis, anti-apoptotic proteins expression, cell survival signaling pathways & their cross-communication and (c) regulating immune responses. The information discussed in the present review will be useful in the drug discovery process as well as the treatment and prevention of colorectal cancer in humans.

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Role of curcumin in preventing familial adenomatous polyposis

Cited by 2 publications

References 26 publications

Curcumin and Colon Cancer

Curcumin and Colon Cancer

Curcumin - A Novel Therapeutic Agent in the Prevention of Colorectal Cancer

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