Curcumin and Colon Cancer

Abstract

Curcumin, derived from turmeric (Curcuma longa) has been extensively studied andvalued for its anti-cancer properties. It acts against a wide range of cancers by hindering the sixmain traits of all cancers, and the most prominent mechanisms include targeting inflammatorypathways. However, since curcumin has low bioavailability, most of it is excreted causing lowsystemic levels, but measurable concentrations in the colonic mucosa. Consequently, colon cancer,which has a high rate of incidence, is one of the more suited targets for curcumin action. The aimof this review is to summarize the mechanisms of curcumin in colon cancer with an emphasis onclinical studies, bioavailability and speculations about turmeric.

A Comprehensive Review on Cutting Tool Material in Hard Turning Performance

“…P.V. Badiger et al [6] studied the influence of cutting parameters on cutting forces, tool wear and surface roughness in hard turning using coated carbide tools. The obtained results indicated that AlCN/AlC coatings exhibited lower cutting force and better surface quality than Nguyen Phu Son, ETJ Volume 09 Issue 04 April 2024…”

“…In addition, the lower cutting forces and cutting temperature were reported in case of using coated carbide tool. Pradeep V Badiger et al [6] TiN/MT TiC,N/Al2O3 coated carbide The tool wear increased with the higher cutting speed. The main wear mechanism is abrasive wear.…”