Role of crossmatch testing when Luminex-SAB is negative
in renal transplantation

Jayant, Kumar; Reccia, Isabella; Julie, Bridson M; Sharma, Ajay; Halawa, Ahmed

doi:10.5604/01.3001.0011.5959

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…This step is taken because IgM is not considered to have clinical significance in transplantation. [7][8][9][10] Despite these modifications, the CDCXM still has certain limitations, such as:…”

Section: Complement-dependent Cytotoxicity Crossmatch: a Starting Pointmentioning

confidence: 99%

“…This step is taken because IgM is not considered to have clinical significance in transplantation. [7–10]…”

Section: Introductionmentioning

confidence: 99%

“…Those factors can interfere with the assay’s efficacy and contribute to high interlaboratory variability. [ 6 , 7 , 9 , 11 ] The histocompatibility laboratory and transplant clinicians need to be aware of these limitations and consider them when interpreting the results of the CDCXM.…”

Section: Introductionmentioning

confidence: 99%

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Crossmatch assays in transplantation: Physical or virtual?: A review

Rocha,

Jaramillo,

Neumann

et al. 2023

Medicine

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The value of the crossmatch test in assessing pretransplant immunological risk is vital for clinical decisions, ranging from the indication of the transplant to the guidance of induction protocols and treatment with immunosuppressants. The crossmatch tests in transplantation can be physical or virtual, each with its advantages and limitations. Currently, the virtual crossmatch stands out for its sensitivity and specificity compared to the physical tests. Additionally, the virtual crossmatch can be performed in less time, allowing for a reduction in cold ischemia time. It shows a good correlation with the results of physical tests and does not negatively impact graft survival. Proper communication between clinicians and the transplant immunology laboratory will lead to a deeper understanding of each patient’s immunological profile, better donor–recipient selection, and improved graft survival.

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Section: Complement-dependent Cytotoxicity Crossmatch: a Starting Pointmentioning

confidence: 99%

“…This step is taken because IgM is not considered to have clinical significance in transplantation. [7–10]…”

Section: Introductionmentioning

confidence: 99%

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Crossmatch assays in transplantation: Physical or virtual?: A review

Rocha,

Jaramillo,

Neumann

et al. 2023

Medicine

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IgG4-related disease presenting as a submucosal tumor of the stomach resected with laparoscopic endoscopic cooperative surgery: a case report

et al. 2020

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Background IgG4-related disease (IgG4-RD) is an immune-mediated disorder in which abundant IgG4-positive plasma cells infiltrate affected organs. There have been reported four cases of probable IgG4-RD presenting as a submucosal tumor of the stomach. We herein report the first case of definite IgG4-RD presenting as a submucosal tumor of the stomach resected with laparoscopic endoscopic cooperative surgery (LECS). Case presentation A 70-year-old woman with a 6-year history of autoimmune pancreatitis was referred to our department because a 15-mm submucosal tumor in the greater curvature of the lower part of the stomach had been identified via upper gastrointestinal endoscopy. Endoscopic ultrasonography showed a 10-mm low-echoic lesion derived from the submucosal layer of the stomach. A fine-needle aspiration biopsy was attempted, but the tumor was too hard for sampling. F-fluorodeoxyglucose (FDG) positron emission tomography showed an FDG uptake, suggesting a possibility of malignant disease. As the diagnosis could not be confirmed, LECS for both the diagnosis and curative treatment was performed. A histopathological examination showed a tumor with IgG4-positive lymphoplasmacytic infiltration and fibrosis. The ratio of IgG4+/IgG+ lymphoplasmacytic cells was > 80%. A laboratory examination showed elevation of the serum IgG4 levels preoperatively. Thus, the final diagnosis was IgG4-RD of the stomach. No recurrence was observed within 1 year after surgery. Conclusions We encountered a case of definite IgG4-RD presenting as a gastric SMT in which a correct diagnosis was achieved by a minimally invasive LECS technique. IgG4-RD may present as a gastric lesion and should be taken into consideration as a differential diagnosis.

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Gastric IgG4-related disease presenting as a mass lesion and masquerading as a gastrointestinal stromal tumor

Ramakrishna¹,

Yewale²,

Vijayakumar³

et al. 2020

J Pathol Transl Med

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IgG4-related disease of the stomach is a rare disorder, and only a few cases have been reported. We present two cases that were identified over a 2-month period in our center. Two male patients aged 52 and 48 years presented with mass lesion in the stomach, which were clinically thought to be gastrointestinal stromal tumor, and they underwent excision of the lesion. Microscopic examination revealed marked fibrosis, which was storiform in one case, associated with diffuse lymphoplasmacytic infiltration and an increase in IgG4positive plasma cells on immunohistochemistry. Serum IgG4 level was markedly elevated. Although rare, IgG4-related disease should be considered in the differential diagnosis of gastric submucosal mass lesions.

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Role of crossmatch testing when Luminex-SAB is negative in renal transplantation

Cited by 3 publications

References 32 publications

Crossmatch assays in transplantation: Physical or virtual?: A review

Crossmatch assays in transplantation: Physical or virtual?: A review

IgG4-related disease presenting as a submucosal tumor of the stomach resected with laparoscopic endoscopic cooperative surgery: a case report

Gastric IgG4-related disease presenting as a mass lesion and masquerading as a gastrointestinal stromal tumor

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