Role of corpus callosum in interhemispheric coherent activity during sleep

Corsi-Cabrera, María; Ondarza, Rodolfo; Martínez-Gutiérrez, V.; Río-Portilla, Yolanda del; Guevara, Miguel Ángel; Ramos-Loyo, Julieta

doi:10.1016/j.clinph.2006.05.008

Cited by 17 publications

(14 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conversely, Corsi-Cabrera and colleagues presented EEG analysis of a single patient with a partial callosotomy before and after surgery and distinguished only minor, nonsignificant changes in bilateral connectivity (CorsiCabrera et al, 1995). Later work by the same group indicated a decrease in bilateral EEG coherence following callosal sectioning; however, connectivity was still present and fluctuated depending on wakefulness (Corsi-Cabrera et al, 2006). These results from human split-brain studies in epileptic patients are equally interesting and incongruent.…”

Section: Introductionmentioning

confidence: 93%

Effects of severing the corpus callosum on electrical and BOLD functional connectivity and spontaneous dynamic activity in the rat brain

Magnuson¹,

Thompson²,

Pan³

et al. 2013

Brain Connectivity

View full text Add to dashboard Cite

Functional networks, defined by synchronous spontaneous blood oxygenation level-dependent (BOLD) oscillations between spatially distinct brain regions, appear to be essential to brain function and have been implicated in disease states, cognitive capacity, and sensing and motor processes. While the topographical extent and behavioral function of these networks has been extensively investigated, the neural functions that create and maintain these synchronizations remain mysterious. In this work callosotomized rodents are examined, providing a unique platform for evaluating the influence of structural connectivity via the corpus callosum on bilateral resting state functional connectivity. Two experimental groups were assessed, a full callosotomy group, in which the corpus callosum was completely sectioned, and a sham callosotomy group, in which the gray matter was sectioned but the corpus callosum remained intact. Results indicated a significant reduction in interhemispheric connectivity in the full callosotomy group as compared with the sham group in primary somatosensory cortex and caudate-putamen regions. Similarly, electrophysiology revealed significantly reduced bilateral correlation in band limited power. Bilateral gamma Band-limited power connectivity was most strongly affected by the full callosotomy procedure. This work represents a robust finding indicating the corpus callosum's influence on maintaining integrity in bilateral functional networks; further, functional magnetic resonance imaging (fMRI) and electrophysiological connectivity share a similar decrease in connectivity as a result of the callosotomy, suggesting that fMRI-measured functional connectivity reflects underlying changes in large-scale coordinated electrical activity. Finally, spatiotemporal dynamic patterns were evaluated in both groups; the full callosotomy rodents displayed a striking loss of bilaterally synchronous propagating waves of cortical activity.

show abstract

Section: Introductionmentioning

confidence: 93%

Effects of severing the corpus callosum on electrical and BOLD functional connectivity and spontaneous dynamic activity in the rat brain

Magnuson¹,

Thompson²,

Pan³

et al. 2013

Brain Connectivity

View full text Add to dashboard Cite

show abstract

“…First, the strength of the correlations are not stronger for cortical regions representing the midline (Butt et al, 2013 ). Second, between-hemisphere resting correlations are preserved in subjects with chronic callosal disconnection (Corsi-Cabrera et al, 2006 ; Uddin et al, 2008 ; Tyszka et al, 2011 ), and finally correlations are strongest between regions of cortex representing symmetrical rather than corresponding locations in visual space.…”

Section: Functional Correlationsmentioning

confidence: 99%

Anatomical and functional plasticity in early blind individuals and the mixture of experts architecture

Bock

Fine

2014

Front. Hum. Neurosci.

View full text Add to dashboard Cite

As described elsewhere in this special issue, recent advances in neuroimaging over the last decade have led to a rapid expansion in our knowledge of anatomical and functional correlations within the normal and abnormal human brain. Here, we review how early blindness has been used as a model system for examining the role of visual experience in the development of anatomical connections and functional responses. We discuss how lack of power in group comparisons may provide a potential explanation for why extensive anatomical changes in cortico-cortical connectivity are not observed. Finally we suggest a framework—cortical specialization via hierarchical mixtures of experts—which offers some promise in reconciling a wide range of functional and anatomical data.

show abstract

“…Post-callosotomy "split-brain" patients offer unique insights into the callosum's role in cognitive systems. To date within-subject comparison of pre-callosotomy and post-callosotomy rsBOLD activation patterns have been reported for 3 patients [10,11] and rsBOLD has been examined in one patient who was at least 40 years post-callosotomy [12].…”

Section: Callosotomymentioning

confidence: 99%