How Important Is the Corpus Callosum In Resting-State Networks?

Abstract

Conflicts of Interest: None (2011 Bursary). We thank Ralph Adolphs for his continued encouragement and support of our research on callosal agenesis and his comments on this editorial.

Brain functional connectivity in individuals with callosotomy and agenesis of the corpus callosum: A systematic review

“…In fact, congenital agenesis of the CC permits developmental adaptive reorganizations (Paul, 2011;Paul et al, 2007); therefore, it is not surprising that individuals without a CC from birth frequently exhibit less severe symptoms of disconnection syndrome compared with patients that underwent surgical transection of the CC during life (Brown et al, 2001;Chiarello, 1980;. In spite of this, however, reports of these cases produce a picture characterized by inconsistencies, as they describe clear examples of FC asymmetries as well as no sign of functional disruption in patients with congenital agenesis (Paul and Tyszka, 2012).…”