Role of copper in tumour angiogenesis—clinical implications

Nasulewicz, Anna; Mazur, Andrzej; Opolski, Adam

doi:10.1016/j.jtemb.2004.02.004

Cited by 143 publications

(111 citation statements)

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“…17,18 Angiogenesis is the initial step in progressive tumor development and metastasis. 19 The first stage in tumor angiogenesis is the activation of endothelial cells. 19 Copper stimulates the proliferation and migration of endothelial cells, and activates several proangiogenic factors including vascular endothelial growth factor, basic fibroblast growth factor, tumor necrosis factor alpha, and interleukin.…”

Section: Discussionmentioning

confidence: 99%

“…19 The first stage in tumor angiogenesis is the activation of endothelial cells. 19 Copper stimulates the proliferation and migration of endothelial cells, and activates several proangiogenic factors including vascular endothelial growth factor, basic fibroblast growth factor, tumor necrosis factor alpha, and interleukin. 19 In the absence of copper, apoceruloplasmin is secreted, but is degraded rapidly.…”

Section: Discussionmentioning

confidence: 99%

“…19 Copper stimulates the proliferation and migration of endothelial cells, and activates several proangiogenic factors including vascular endothelial growth factor, basic fibroblast growth factor, tumor necrosis factor alpha, and interleukin. 19 In the absence of copper, apoceruloplasmin is secreted, but is degraded rapidly. 17 Increased expression of ceruloplasmin has been reported in the serum of several cancer patients.…”

Section: Discussionmentioning

confidence: 99%

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Plasma proteomic analysis of patients with squamous cell carcinoma of the uterine cervix

et al. 2008

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Objective: To compare plasma protein expression between patients with squamous cell carcinoma (SCC) of the cervix and normal controls. Methods: Plasma samples from patients with benign gynecological disease (normal cervix, n=6) and cervical cancer (SCC, n=6) were subjected to plasma proteomic analysis using two dimensional gel electrophoresis (2-DE) and matrix-assisted laser desorption/ionization mass spectroscopy (MALDI-MS). Western blotting and immunoturbidimetric assay were performed to validate the results of 2-DE. Results: Eight proteins showed differential expression between controls and SCC patients; six (ceruloplasmin, complement C3, afamin precursor, alpha-1-B-glycoprotein, transferrin, alpha-fibrinogen precursor) were up-regulated, while two (chain A, crystal structure of antithrombin and apolipoprotein A-IV precursor) were down-regulated in the plasma of SCC patients. Western blotting analysis revealed significant elevation of ceruloplasmin, complement C3, afamin, and alpha-1-B-glycoprotein in the plasma of SCC patients in comparison to controls. Immunoturbidimetric assay of a larger group confirmed the results of 2-DE and Western blotting, and showed that ceruloplasmin and complement C3 were significantly elevated in the plasma of SCC patients in comparison with controls and patients with carcinoma in situ (CIS) of the uterine cervix. Conclusion: Plasma protein expression determined using 2-DE and MALDI-MS will give a chance to identify tumor-specific biomarkers for SCC of the cervix.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Plasma proteomic analysis of patients with squamous cell carcinoma of the uterine cervix

et al. 2008

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“…39 In rodents (LEC rats), excessive copper accumulation in the liver has caused liver tumors. 40 A few case-control studies have suggested a link between high levels of copper in blood samples collected from cases with esophageal cancers and some other gastrointestinal tumors 36,41 as compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Salt tea consumption and esophageal cancer: A possible role of alkaline beverages in esophageal carcinogenesis

Dar

Bhat

Shah

et al. 2014

Intl Journal of Cancer

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Salt tea is the most commonly used beverage in Kashmir, India, where esophageal squamous cell carcinoma (ESCC) is the most common cancer. Salt tea is brewed in a unique way in Kashmir, usually with addition of sodium bicarbonate, which makes salt tea alkaline. As little information about the association between salt tea drinking and ESCC was available, we conducted a large-scale case-control study to investigate this association in Kashmir. We recruited 703 histologically confirmed cases of ESCC and 1664 controls individually matched to cases for age, sex, and district of residence. Conditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). Participants who consumed >1,250 ml day 21 showed an increased risk of ESCC (OR 5 2.60, 95% CIs 5 1.68-4.02). Samovar (a special vessel for the beverage preparation) users (OR 5 1.77, 95% CIs 1.25-2.50) and those who ate cereal paste with salt tea (OR 5 2.14, 95% CIs 5 1.55-2.94) or added bicarbonate sodium to salt tea (OR 5 2.12, 95% CIs 5 1.33-3.39) were at higher risk of ESCC than others. When analysis was limited to alkaline tea drinkers only, those who both consumed cereal paste with salt tea and used samovar vessel were at the highest risk (OR 5 4.58, 95% CIs 5 2.04-10.28). This study shows significant associations of salt tea drinking and some related habits with ESCC risk.

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“…Studies in cell cultures and animal models have demonstrated that Cu is able to induce VEGF mRNA transcription and protein expression (31)(32). Copper, but not other metals, is a co-factor required for several angiogenic mediators including VEGF (32), basic fibroblast growth factor (bFGF) (33), interleukin 1 (IL-1) and interleukin 8 (IL-8) (34), all of which are essential regulators for tumor angiogenesis (35)(36)(37)(38). Tumors are dependent on angiogenesis for their growth, invasion and metastasis (39)(40), and Cu plays an important role in this process.…”

Section: Coppermentioning

confidence: 99%

New applications of old metal-binding drugs in the treatment of human cancer

Dou¹

2012

Front Biosci

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Significant advances in the use of metal complexes, precipitated by platinum, have fostered a renewed interest in harnessing their rich potential in the treatment of cancer. In addition to platinum-based complexes, the anticancer properties of other metals such as ruthenium have been realized, and ruthenium-based compounds are currently being investigated in clinical trials. Since the process of drug development can be expensive and cumbersome, finding new applications of existing drugs may provide effective means to expedite the regulatory process in bringing new drugs to the clinical setting. Encouraging findings from laboratory studies reveal significant anticancer activity from different classes of metal-chelating compounds, such as disulfiram, clioquinol, and dithiocarbamate derivatives that are currently approved for the treatment of various pathological disorders. Their use as coordination complexes with metals such as copper, zinc, and gold that target the ubiquitin-proteasome pathway have shown significant promise as potential anticancer agents. This review discusses the unique role of several selected metals in relation to their anti-cancer properties as well as the new therapeutic potential of several previously approved metal-chelating drugs. In vitro and in vivo experimental evidence along with mechanisms of action (e.g., via targeting the tumor proteasome) will also be discussed with anticipation of strengthening this exciting new concept. KeywordsDisulfiram; Clioquinol; Dithiocarbamates; Copper; Zinc; Ubiquitin-Proteasome Pathway; Proteasome Inhibitor; Chymotrypsin-Like Activity; Review INTRODUCTION The use of metal complexes for cancer treatmentThe development of metal-based complexes for the treatment of cancer began with the discovery of the anti-cancer properties of cisplatin in the early 1960s (Figure 1). Over 90% of testicular cancer cases have been cured by cisplatin, and it has also been important in the treatment of several other types of cancer, including ovarian, cervical, bladder, head and neck, melanoma, and lymphomas (1). Cisplatin interacts with DNA and forms adducts which interfere with the replication and transcription processes, and ultimately triggers apoptosis (2). These cisplatin-DNA interactions have been extensively studied, and it has been clearly shown that a (Pt)-GG intrastrand cross-link is responsible for the cytotoxicity of Send correspondence to: Qing Ping Dou, The Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, and Departments of Oncology, Pharmacology and Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA, doup@karmanos.org. NIH Public Access Author ManuscriptFront Biosci (Schol Ed). Author manuscript; available in PMC 2013 May 07. Published in final edited form as:Front Biosci (Schol Ed). ; 4: 375-391. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript cisplatin (3). However, the toxicities associated with cisplatin, coupled with intrinsic and acquired drug resistance, ha...

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Role of copper in tumour angiogenesis—clinical implications

Cited by 143 publications

References 40 publications

Plasma proteomic analysis of patients with squamous cell carcinoma of the uterine cervix

Plasma proteomic analysis of patients with squamous cell carcinoma of the uterine cervix

Salt tea consumption and esophageal cancer: A possible role of alkaline beverages in esophageal carcinogenesis

New applications of old metal-binding drugs in the treatment of human cancer

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