Role of contrasuppression in the adoptive transfer of immunity.

Abstract

The data presented in this paper show that the population of cells that adoptively transfer contact hypersensitivity are Lyt-1+ 2-, I-J- and nonadherent to V. villosa lectin. However, the adoptive transfer of immunity by this population of cells is successful only when the recipient has been treated in such a way as to impair the host immunosuppression mechanism. This population cannot, on its own, transfer immunity to adult, untreated naive recipients unless an additional population of immunoregulatory cells is present. This immunoregulatory population does not itself adoptively transfer immunity. This latter population is differentiated from the immune cells in that they are Lyt-1+ 2-, I-J+ and are adherent to V. villosa lectin. Both populations are required to adoptively transfer immunity to adult untreated naive recipients.

Epicutaneous Immunization with Protein Antigen in the Presence of TLR4 Ligand Induces TCRαβ+CD4+ T Contrasuppressor Cells That Reverse Skin-Induced Suppression of Th1-Mediated Contact Sensitivity

“…Two types of specialized Tcs cells that modulate CS, both of which are CD4 ϩ , have been described in mice. One is nonspecific and is present in both immune and nonimmune animals (30). The second Tcs cell is Ag specific, shields immune cells against Ag-specific CD8 ϩ Ts cells, and is triggered by Ag-Ab complexes (31,32).…”

Effect of Splenectomy on the Development of Experimental Autoimmune Encephalomyelitis in Rats with Different Genetic Background

“…This could suggest an increased suppressor activity at the induc tion process of the disease as a result of the elimina tion of contrasuppressive cells [3] by splenectomy. Iv erson et al [4] studied immunoregulatory mechanisms at adoptive transfer of contact hypersensitivity and found an important role for contrasuppressive cells.…”

Polyclonal B Cell Activators Inhibit Contact Sensitivity to Oxazolone in Mice by Potentiating the Production of Anti-Hapten Antibodies that Induce T Suppressor Lymphocytes Acting through the Release of Soluble Factors

“…The appearance of these cells already on day 6 after sensitization makes it unlikely that the genera tion of Ts cells in our model is the consequence of a decrease in contrasuppressor signals, since anti-idiotype (anti-ld) B contrasuppressor cells, capable of blocking Ts cells, have been described in CS as occur ring on day 8 of the sensitization process [5]. How ever, it must be borne in mind that anti-ox Abs may interfere with T contrasuppressor cells [15], and this point remains to be clarified.…”