“…Acute adverse events (AE) can be divided according to its mechanism into immediate hypersensitivity (allergic-like) reactions Magnetic Resonance Imaging 34 (2016) [1394][1395][1396][1397][1398] (typically occur within seconds or minutes after the injection and imply an immune response to the whole or part of the GBCA) or physiologic reactions (coldness, warmth, or pain at the injection site, nausea with or without vomiting, headache, paresthesias, and dizziness). According to severity, AE can be classified into mild (self-limited with signs and symptoms showing no evidence of progression), moderate (more pronounced symptoms, such as bronchospasm, laryngeal edema, and/or generalized erythema) or severe (life threatening, including severe laryngeal edema, convulsions, profound hypotension, unresponsiveness, arrhythmia, and/or cardiopulmonary arrest) [13].…”