“…extracts in patients suffering from constipation following treatments with temozolomide and nitrosoureas significantly improved the number of bowel movements, sense of incomplete evacuation, and stool consistency. 47 In a nonrandomized clinical trial with the maitake D-fraction carried out in Japan on 165 patients with stage III-IV cancer aged between 25 and 65 years, various chemotherapy side effects (e.g., loss of appetite, vomiting, nausea, hair loss, and leukopenia) were strongly reduced in 90% of patients. Pain reduction was also found in 83% of patients.…”