Clinical study of anesthetization by dezocine combined with propofol for indolent colonoscopy

Xu, Binbin; Zhao, Xiaoliang; Xu, Guiping

doi:10.3748/wjg.v22.i24.5609

Cited by 10 publications

(14 citation statements)

References 37 publications

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“…Following lateral positioning, an oxygen inhalation mask was administered immediately at a rate of 3L/min. The patients in the alfentanil and propofol (AP) group were administered alfentanil (Yichang Humanwell Pharmaceutical, Co., Ltd., China, 13S03051) 10 μg/kg and propofol (Corden Pharma S.P.A., RX061) 2 mg/kg [22][23][24][25]. Patients in remimazolam groups were received alfentanil 10 μg/kg, followed by remimazolam besylate (Yichang Humanwell Pharmaceutical, Co., Ltd., China, 70,705,021) 0.1 mg/ kg (AR1 group), 0.15 mg/kg (AR2 group), or 0.2 mg/kg (AR3 group).…”

Section: Anesthesia Management and Interventionmentioning

confidence: 99%

Sedative effect of remimazolam combined with alfentanil in colonoscopic polypectomy: a prospective, randomized, controlled clinical trial

et al. 2022

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Background Remimazolam is a newer benzodiazepine with properties of rapid onset, short duration of action, and fast recovery. Our study was to evaluate the effects of different doses of remimazolam combined with alfentanil in colonoscopic polypectomy. Methods One hundred twenty patients were randomly divided into four groups: alfentanil and propofol (AP) group, alfentanil and remimazolam 0.1 mg/kg (AR1 group), 0.15 mg/kg (AR2 group), or 0.2 mg/kg (AR3 group). Patients in the four groups received alfentanil 10 μg/kg, followed by propofol 2 mg/kg and three dosages of remimazolam. Modified Observer's Assessment of Alertness and Sedation (MOAA/S) scale, heart rate (HR), oxygen saturation (SpO2), respiratory rate (RR), bispectral index (BIS) values and mean arterial pressure (MAP) were collected at intervals of 5 min and analyzed at different time points: before anesthesia (T0), 5 min (T1), 10 min (T2), 15 min after anesthesia (T3) and at the end of surgery (T4). The average MAP was calculated utilizing the average of all MAP values. The primary outcome was the success rate of sedation. Secondary outcomes included time to full alert and adverse events. Results The success rate of sedation was 100% among the four groups. The incidence of hypotension was significantly decreased (all P < 0.05) and the average MAP was higher in AR1-AR3 groups than AP group (all P < 0.001). None of the patients developed bradycardia or hypertension during surgery in all study groups. BIS values were higher (all P < 0.001) and the time to full alert was statistically shorter in AR1-AR3 groups (all P < 0.05) compared with the AP group. The MOAA/S score in AR1 was higher than AR2 (P < 0.05) and the AR3 group (P < 0.05) at T1 and BIS values in the AR1 group were significantly higher than AR3 group (P < 0.05) at T4. Conclusions Remimazolam combined with alfentanil have a non-inferior sedative effect than propofol during the colonoscopic polypectomy. Moreover, this combination of two short-acting drugs might be a safer alternative. Trial registration The clinical trial was registered on (16/05/2021, ChiCTR2100046492).

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Section: Anesthesia Management and Interventionmentioning

confidence: 99%

Sedative effect of remimazolam combined with alfentanil in colonoscopic polypectomy: a prospective, randomized, controlled clinical trial

et al. 2022

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“…Another study among health mice indicated that dezocine antagonizes morphine analgesia on acute nociception upon simultaneous administration [ 23 ]. A study conducted by the Xu et al [ 24 ] showed that dezocine combined with propofol can be successfully used for the anesthetization of indolent colonoscopy patients without pain and should be widely used. Therefore, our meta-analysis obtained a consistent result with the above-mentioned studies.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the efficacy and safety between dezocine injection and morphine injection for persistence of pain in Chinese cancer patients: a meta-analysis

Wang

et al. 2017

Bioscience Reports

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The association between the efficacy and safety of dezocine injection and morphine injection for persistence of pain in patients with cancer had yielded controversial results. Therefore, we conduct a meta-analysis of existing observational published studies to assess the relationship between them among Chinese. We conducted a comprehensive research from the databases of PubMed, Web of Science, and Wan Fang Med Online for the related studies up to October 2016. Summary odds ratio (OR) with 95% confidence interval (95% CI) were calculated with the random effects model. Nine published studies comprising 333 dezocine injection patients and 321 morphine injection patients were included in this meta-analysis. Our results suggested that there was no statistical significance between dezocine injection and morphine injection at the case number of effective pain relief (EPR) [OR = 0.97, 95% CI (0.77–1.22), I2 = 0.0, P for heterogeneity = 1.000]. However, the rate of adverse drug reaction (ADR) caused by dezocine injection was 56% less than that caused by morphine injection, the difference was statistically significant [OR = 0.44, 95% CI (0.30–0.65), I2 = 0.0, P for heterogeneity = 0.980]. No between-study heterogeneity and publication bias were found. In conclusions, this meta-analysis indicates that there is no significant association on the efficacy of persistence of pain in patients with cancer between dezocine injection and morphine injection among Chinese. However, dezocine injection was with less ADR compared with morphine injection.

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“…Propofol has a sedative effect, while both dezocine and fentanyl exert analgesic effects. Dezocine activates κ receptor in cerebral cortex, leading to slow onset and long duration of analgesia [3,7,8], Table 3: Serum levels of inflammation-related endocrine hormones before and after colonoscopy examination (mean ± SD) while fentanyl brings about fast onset but shortlived analgesia through activation of the μ and δ receptors in the central nervous system (CNS). Thus the use of fentanyl after colonoscopy examination is not ideal.…”

Section: Discussionmentioning

confidence: 99%

Analgesic, anti-inflammatory and immuno-modulatory effects of dezocine-propofol anesthesia combination following colonoscopy

Li¹,

Zhuang²,

Chen³

2017

Trop. J. Pharm Res

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Purpose: To study and compare the analgesic, anti-inflammatory and immuno-modulatory effects of dezocine-propofol, and fentanyl-propofol combinations in colonoscopy. Methods: One hundred and thirty-four patients who received painless colonoscopy in Eastern Medical -HTP), 5-hydroxy indole acetic acid (5-HIAA), substance P (SP), prostaglandin E2 (PGE2), C-reactive protein (CRP), heat shock protein 70 (HSP70), Interleukin-1 β(IL-1β), adrenocorticotropic hormone (ACTH), Cortisol (Cor), Inositol (Ins), c-peptide (C-P), immunoglobulin G (IgG) and immunoglobulin A (IgA), complement 3 (C3) and complement 4 (C4) before and during colonoscopy between the two groups of patients. However, after the examination, serum levels of SP, PGE2, CRP, HSP70, ACTH, Cor,

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Clinical study of anesthetization by dezocine combined with propofol for indolent colonoscopy

Abstract: This study revealed that dezocine combined with propofol can be successfully used for the anesthetization of indolent colonoscopy patients without pain and should be widely used.

Cited by 10 publications

References 37 publications

Sedative effect of remimazolam combined with alfentanil in colonoscopic polypectomy: a prospective, randomized, controlled clinical trial

Sedative effect of remimazolam combined with alfentanil in colonoscopic polypectomy: a prospective, randomized, controlled clinical trial

Comparison of the efficacy and safety between dezocine injection and morphine injection for persistence of pain in Chinese cancer patients: a meta-analysis

Analgesic, anti-inflammatory and immuno-modulatory effects of dezocine-propofol anesthesia combination following colonoscopy

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