Abstract:Background: FOXP3 gene, is a major regulator of T-regulatory (Treg) cells that have a critical role in immune responses to alloantigens and acute cellular rejection (ACR) after liver transplantation (LT). Objectives: To investigate the role of FOXP-3 rs3761548 gene polymorphism on ACR after LT and to determine the relation between the circulating CD4 + CD25 + FOXP-3 + Treg cells, and infection on the severity of ACR.Methodology: Blood samples were obtained from 60 allograft liver recipients and 20 healthy volu… Show more
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